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Weekly cisplatin and nab‑paclitaxel neoadjuvant chemoradiotherapy increases pathological complete response in locally advanced esophageal squamous cell carcinoma: A real‑world study

  • Authors:
    • Li Li
    • Xuquan Jing
    • Jiling Niu
    • Yan Yi
    • Yujie Wang
    • Ke Zhao
    • Jingyu Luo
    • Jinming Yu
    • Hui Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China, Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China, Department of Thoracic Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Article Number: 293
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    Published online on: May 13, 2026
       https://doi.org/10.3892/ol.2026.15648
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Abstract

Although neoadjuvant chemoradiotherapy (nCRT) is the standard treatment regimen for patients with locally advanced esophageal squamous cell carcinoma (LA‑ESCC), no consensus exists regarding the optimal chemotherapy regimen. The present study aimed to compare the safety/efficacy of weekly (QW) vs. triweekly (Q3W) cisplatin/nab‑paclitaxel nCRT in LA‑ESCC. This retrospective study analyzed 136 patients with LA‑ESCC who underwent esophagectomy after nCRT (QW, n=32; Q3W, n=104). The data included pathological complete response (pCR), major pathological response (MPR), toxicity, survival and postoperative outcomes. The results demonstrated that QW exhibited significantly higher pCR (56.25 vs. 33.65%; P=0.022) and MPR (81.25 vs. 61.54%; P=0.039) rates than Q3W. Hematological toxicity rates were lower for QW, including neutropenia of all grades (46.88% vs. 70.81%, P=0.0001) and thrombocytopenia of all grades (18.75% vs. 31.73%, P=0.033). Grade ≥3 leukopenia (18.75 vs. 51.92%; P=0.001) and grade ≥3 neutropenia (15.62 vs. 38.46%; P=0.016) were less frequent in QW. In addition, the incidence of acute pneumonia of all grades was also lower (0% vs. 16.35%, P>0.05). However, survival outcomes were comparable between the groups, including 1‑year overall survival (QW vs. Q3W, 96.6 vs. 100.0%) and progression‑free survival (86.5 vs. 85.6%) rates (P>0.05). In conclusion, QW cisplatin/nab‑paclitaxel nCRT achieved superior pCR rates and reduced hematological toxicity compared with Q3W dosing in LA‑ESCC, thus suggesting its potential use as a safer and more effective neoadjuvant regimen. The survival benefit remains to be validated with an extended follow‑up.
View Figures

Figure 1

Clinical staging at initial diagnosis
vs. postoperative pathological staging. The downstaging rate
reached 80.14%, and the proportion of patients with stage II or III
disease decreased from 96.32 to 26.47%.

Figure 2

Kaplan-Meier curves for (A) PFS and
(B) OS in the QW vs. Q3W nab-paclitaxel groups. There were no
statistically significant differences in PFS (P=0.692) or OS
(P=0.829) between the two groups. PFS, progression-free survival;
OS, overall survival; QW, weekly; Q3W, tri-weekly; CI, confidence
interval; HR, hazard ratio.
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Copy and paste a formatted citation
Spandidos Publications style
Li L, Jing X, Niu J, Yi Y, Wang Y, Zhao K, Luo J, Yu J and Zhu H: Weekly cisplatin and nab‑paclitaxel neoadjuvant chemoradiotherapy increases pathological complete response in locally advanced esophageal squamous cell carcinoma: A real‑world study. Oncol Lett 32: 293, 2026.
APA
Li, L., Jing, X., Niu, J., Yi, Y., Wang, Y., Zhao, K. ... Zhu, H. (2026). Weekly cisplatin and nab‑paclitaxel neoadjuvant chemoradiotherapy increases pathological complete response in locally advanced esophageal squamous cell carcinoma: A real‑world study. Oncology Letters, 32, 293. https://doi.org/10.3892/ol.2026.15648
MLA
Li, L., Jing, X., Niu, J., Yi, Y., Wang, Y., Zhao, K., Luo, J., Yu, J., Zhu, H."Weekly cisplatin and nab‑paclitaxel neoadjuvant chemoradiotherapy increases pathological complete response in locally advanced esophageal squamous cell carcinoma: A real‑world study". Oncology Letters 32.1 (2026): 293.
Chicago
Li, L., Jing, X., Niu, J., Yi, Y., Wang, Y., Zhao, K., Luo, J., Yu, J., Zhu, H."Weekly cisplatin and nab‑paclitaxel neoadjuvant chemoradiotherapy increases pathological complete response in locally advanced esophageal squamous cell carcinoma: A real‑world study". Oncology Letters 32, no. 1 (2026): 293. https://doi.org/10.3892/ol.2026.15648
Copy and paste a formatted citation
x
Spandidos Publications style
Li L, Jing X, Niu J, Yi Y, Wang Y, Zhao K, Luo J, Yu J and Zhu H: Weekly cisplatin and nab‑paclitaxel neoadjuvant chemoradiotherapy increases pathological complete response in locally advanced esophageal squamous cell carcinoma: A real‑world study. Oncol Lett 32: 293, 2026.
APA
Li, L., Jing, X., Niu, J., Yi, Y., Wang, Y., Zhao, K. ... Zhu, H. (2026). Weekly cisplatin and nab‑paclitaxel neoadjuvant chemoradiotherapy increases pathological complete response in locally advanced esophageal squamous cell carcinoma: A real‑world study. Oncology Letters, 32, 293. https://doi.org/10.3892/ol.2026.15648
MLA
Li, L., Jing, X., Niu, J., Yi, Y., Wang, Y., Zhao, K., Luo, J., Yu, J., Zhu, H."Weekly cisplatin and nab‑paclitaxel neoadjuvant chemoradiotherapy increases pathological complete response in locally advanced esophageal squamous cell carcinoma: A real‑world study". Oncology Letters 32.1 (2026): 293.
Chicago
Li, L., Jing, X., Niu, J., Yi, Y., Wang, Y., Zhao, K., Luo, J., Yu, J., Zhu, H."Weekly cisplatin and nab‑paclitaxel neoadjuvant chemoradiotherapy increases pathological complete response in locally advanced esophageal squamous cell carcinoma: A real‑world study". Oncology Letters 32, no. 1 (2026): 293. https://doi.org/10.3892/ol.2026.15648
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