|
1
|
Bray F, Laversanne M, Sung H, Ferlay J,
Siegel RL, Soerjomataram I and Jemal A: Global cancer statistics
2022: GLOBOCAN estimates of incidence and mortality worldwide for
36 cancers in 185 countries. CA Cancer J Clin. 74:229–263.
2024.PubMed/NCBI
|
|
2
|
Siegel RL, Wagle NS, Cercek A, Smith RA
and Jemal A: Colorectal cancer statistics, 2023. CA Cancer J Clin.
73:233–254. 2023.PubMed/NCBI
|
|
3
|
Islami F, Miller KD, Siegel RL, Fedewa SA,
Ward EM and Jemal A: Disparities in liver cancer occurrence in the
United States by race/ethnicity and state. CA Cancer J Clin.
67:273–289. 2017.PubMed/NCBI
|
|
4
|
Mantovani A, Marchesi F, Malesci A, Laghi
L and Allavena P: Tumour-associated macrophages as treatment
targets in oncology. Nat Rev Clin Oncol. 14:399–416. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Cen X, Li Z and Chen X: Ubiquitination in
the regulation of autophagy. Acta Biochim Biophys Sin (Shanghai).
55:1348–1357. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Mattei AL, Bailly N and Meissner A: DNA
methylation: A historical perspective. Trends Genet. 38:676–707.
2022. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Bilbrough T, Piemontese E and Seitz O:
Dissecting the role of protein phosphorylation: A chemical biology
toolbox. Chem Soc Rev. 51:5691–5730. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Zhang D, Tang Z, Huang H, Zhou G, Cui C,
Weng Y, Liu W, Kim S, Lee S, Perez-Neut M, et al: Metabolic
regulation of gene expression by histone lactylation. Nature.
574:575–580. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Li F, Zhang H, Huang Y, Li D, Zheng Z, Xie
K, Cao C, Wang Q, Zhao X, Huang Z, et al: Single-cell transcriptome
analysis reveals the association between histone lactylation and
cisplatin resistance in bladder cancer. Drug Resist Updat.
73:1010592024. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Wei J, Ding Q, Wang H and Liu Y:
Lactylation in digestive system tumors: From mechanisms to
therapeutic target. Front Oncol. 15:16072492025. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Wang G, Zou X, Chen Q, Nong W, Miao W, Luo
H and Qu S: The relationship and clinical significance of
lactylation modification in digestive system tumors. Cancer Cell
Int. 24:2462024. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Vander Heiden MG, Cantley LC and Thompson
CB: Understanding the Warburg effect: The metabolic requirements of
cell proliferation. Science. 324:1029–1033. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Huang H, Wang S, Xia H, Zhao X, Chen K,
Jin G, Zhou S, Lu Z, Chen T, Yu H, et al: Lactate enhances NMNAT1
lactylation to sustain nuclear NAD+ salvage pathway and promote
survival of pancreatic adenocarcinoma cells under glucose-deprived
conditions. Cancer Lett. 588:2168062024. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Boidot R, Végran F, Meulle A, Le Breton A,
Dessy C, Sonveaux P, Lizard-Nacol S and Feron O: Regulation of
monocarboxylate transporter MCT1 expression by p53 mediates inward
and outward lactate fluxes in tumors. Cancer Res. 72:939–948. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Faghihkhorasani F, Moosavi M, Rasool
Riyadh Abdulwahid AH, Kavei M, Karimi S, Seyed Karimi M, Vezvaei P,
Manafi Varkiani M, Aref AR and Ebrahimi N: Role of monocarboxylate
transporters in cancer immunology and their therapeutic potential.
Br J Pharmacol. 182:4421–4457. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Liu T, Han S, Yao Y and Zhang G: Role of
human monocarboxylate Transporter 1 (hMCT1) and 4 (hMCT4) in tumor
cells and the tumor microenvironment. Cancer Manag Res. 15:957–975.
2023. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Whitaker-Menezes D, Martinez-Outschoorn
UE, Lin Z, Ertel A, Flomenberg N, Witkiewicz AK, Birbe RC, Howell
A, Pavlides S, Gandara R, et al: Evidence for a stromal-epithelial
‘lactate shuttle’ in human tumors: MCT4 is a marker of oxidative
stress in cancer-associated fibroblasts. Cell Cycle. 10:1772–1783.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Li C, Ge C, Wang Q, Teng P, Jia H, Yao S
and Huang Z: Sirtuin 3-mediated delactylation of malic enzyme 2
disrupts redox balance and inhibits colorectal cancer growth. Cell
Oncol (Dordr). 48:979–990. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Liu N, Luo J, Kuang D, Xu S, Duan Y, Xia
Y, Wei Z, Xie X, Yin B, Chen F, et al: Lactate inhibits ATP6V0d2
expression in tumor-associated macrophages to promote
HIF-2alpha-mediated tumor progression. J Clin Invest. 129:631–646.
2019. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Brand A, Singer K, Koehl GE, Kolitzus M,
Schoenhammer G, Thiel A, Matos C, Bruss C, Klobuch S, Peter K, et
al: LDHA-Associated lactic acid production blunts tumor
immunosurveillance by T and NK cells. Cell Metab. 24:657–671. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Watson MJ, Vignali PDA, Mullett SJ,
Overacre-Delgoffe AE, Peralta RM, Grebinoski S, Menk AV,
Rittenhouse NL, DePeaux K, Whetstone RD, et al: Metabolic support
of tumour-infiltrating regulatory T cells by lactic acid. Nature.
591:645–651. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Zappasodi R, Serganova I, Cohen IJ, Maeda
M, Shindo M, Senbabaoglu Y, Watson MJ, Leftin A, Maniyar R, Verma
S, et al: CTLA-4 blockade drives loss of Treg stability
in glycolysis-low tumours. Nature. 591:652–658. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Yang D, Yin J, Shan L, Yi X, Zhang W and
Ding Y: Identification of lysine-lactylated substrates in gastric
cancer cells. IScience. 25:1046302022. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Gu J, Zhou J, Chen Q, Xu X, Gao J, Li X,
Shao Q, Zhou B, Zhou H, Wei S, et al: Tumor metabolite lactate
promotes tumorigenesis by modulating MOESIN lactylation and
enhancing TGF-β signaling in regulatory T cells. Cell Rep.
39:1109862022. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Gao X, Zhou S, Qin Z, Li D, Zhu Y and Ma
D: Upregulation of HMGB1 in tumor-associated macrophages induced by
tumor cell-derived lactate further promotes colorectal cancer
progression. J Transl Med. 21:532023. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Zhu R, Ye X, Lu X, Xiao L, Yuan M, Zhao H,
Guo D, Meng Y, Han H, Luo S, et al: ACSS2 acts as a lactyl-CoA
synthetase and couples KAT2A to function as a lactyltransferase for
histone lactylation and tumor immune evasion. Cell Metab.
37:361–376.e7. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Liu R, Ren X, Park YE, Feng H, Sheng X,
Song X, AminiTabrizi R, Shah H, Li L, Zhang Y, et al: Nuclear
GTPSCS functions as a lactyl-CoA synthetase to promote histone
lactylation and gliomagenesis. Cell Metab. 37:377–394.e9. 2025.
View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Yu J, Chai P, Xie M, Ge S, Ruan J, Fan X
and Jia R: Histone lactylation drives oncogenesis by facilitating
m6A reader protein YTHDF2 expression in ocular melanoma. Genome
Biol. 22:852021. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Zhai G, Niu Z, Jiang Z, Zhao F, Wang S,
Chen C, Zheng W, Wang A, Zang Y, Han Y, et al: DPF2 reads histone
lactylation to drive transcription and tumorigenesis. Proc Natl
Acad Sci USA. 121:e24214961212024. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Ju J, Zhang H, Lin M, Yan Z, An L, Cao Z,
Geng D, Yue J, Tang Y, Tian L, et al: The alanyl-tRNA synthetase
AARS1 moonlights as a lactyltransferase to promote YAP signaling in
gastric cancer. J Clin Invest. 134:e1745872024. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Mao Y, Zhang J, Zhou Q, He X, Zheng Z, Wei
Y, Zhou K, Lin Y, Yu H, Zhang H, et al: Hypoxia induces
mitochondrial protein lactylation to limit oxidative
phosphorylation. Cell Res. 34:13–30. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Zong Z, Xie F, Wang S, Wu X, Zhang Z, Yang
B and Zhou F: Alanyl-tRNA synthetase, AARS1, is a lactate sensor
and lactyltransferase that lactylates p53 and contributes to
tumorigenesis. Cell. 187:2375–2392.e33. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Gaffney DO, Jennings EQ, Anderson CC,
Marentette JO, Shi T, Schou Oxvig AM, Streeter MD, Johannsen M,
Spiegel DA, Chapman E, et al: Non-enzymatic lysine lactoylation of
glycolytic enzymes. Cell Chem Biol. 27:206–213.e6. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Zalambani C, Rizzardi N, Marziali G,
Foschi C, Morselli S, Djusse ME, Naldi M, Fato R, Calonghi N and
Marangoni A: Role of D(−)-Lactic acid in prevention of chlamydia
trachomatis infection in an in vitro model of HeLa cells.
Pathogens. 12:8832023. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Zhao Q, Wang Q, Yao Q, Yang Z, Li W, Cheng
X, Wen Y, Chen R, Xu J, Wang X, et al: Nonenzymatic lysine
D-lactylation induced by glyoxalase II substrate SLG dampens
inflammatory immune responses. Cell Res. 35:97–116. 2025.
View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Yang Z, Yan C, Ma J, Peng P, Ren X, Cai S,
Shen X, Wu Y, Zhang S, Wang X, et al: Lactylome analysis suggests
lactylation-dependent mechanisms of metabolic adaptation in
hepatocellular carcinoma. Nat Metab. 5:61–79. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Peng X and Du J: Histone and non-histone
lactylation: Molecular mechanisms, biological functions, diseases,
and therapeutic targets. Mol Biomed. 6:382025. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Li Z, Zhu T, Wu Y, Yu Y, Zang Y, Yu L and
Zhang Z: Functions and mechanisms of non-histone post-translational
modifications in cancer progression. Cell Death Discov. 11:1252025.
View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Sheng X, Lin H, Cole PA and Zhao Y:
Biochemistry and regulation of histone lysine L-lactylation. Nat
Rev Mol Cell Bio. 27:95–109. 2026. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Zong Z, Zhang L and Zhou F: Lactylation in
cancer: Advances, challenges, and future perspectives. Cancer Res.
85:3192–3195. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Wei E, Ji D, Jia Y, Sun Z, Gao C, Zeng C,
Wang C, Yu M, Shang G, Xie L, et al: BRD9 recognizes
lactate-induced H3K18 lactylation to drive oncogenic chromatin
remodeling in hepatocellular carcinoma. Cell Death Differ. Mar
7–2026.doi: 10.1038/s41418-026-01698-6. View Article : Google Scholar
|
|
42
|
Li Y, Peng J, Wu D, Xie Q, Hou Y, Li L,
Zhang X, Liang Y, Feng J, Chen J, et al: Histone
lactylation-boosted AURKB facilitates colorectal cancer progression
by inhibiting HNRNPM-mediated PSAT1 mRNA degradation. J Exp Clin
Cancer Res. 44:2332025. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Zhu JF, Guo DP, Lv HN, Liang ZY, Song J
and Zeng W: Histone lactylation-mediated up-regulation of IGF2BP2
enhances ferroptosis resistance via Nrf2 in colorectal cancer. Clin
Transl Med. 15:e705512025. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Ji Y, Xu Z, Tang L, Huang T, Mu X, Ni C,
Tang B, Lu H, Zhang C, Yang S and Wang X: O-GlcNAcylation of YBX1
drives a glycolysis-histone lactylation feedback loop in
hepatocellular carcinoma. Cancer Lett. 631:2179572025. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Ding F, Guo Y, Zhang H, Zhong Y, Zhang D,
Huang Q, Zheng Z, Liu G, Zhang X and Weng S: High glucose-induced
mitochondrial fission drives pancreatic cancer progression through
the H3K18la/TTK/BUB1B signal pathway. Cell Signal. 135:1120272025.
View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Hanahan D and Coussens LM: Accessories to
the crime: Functions of cells recruited to the tumor
microenvironment. Cancer Cell. 21:309–322. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Zang Y, Wang A, Zhang J, Xia M, Jiang Z,
Jia B, Lu C, Chen C, Wang S, Zhang Y, et al: Hypoxia promotes
histone H3K9 lactylation to enhance LAMC2 transcription in
esophageal squamous cell carcinoma. iScience. 27:1101882024.
View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Wang F, Yang C, Zheng F, Yan Y, Li G, Feng
Y, Xu H, He Z, Cai D, Sun H, et al: METTL1 mediates PKM m7G
modification to regulate CD155 expression and promote immune
evasion in colorectal cancer. J Transl Med. 22:11612024. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Qian Z, Cai X, Wu F, Ye Z and Wu J:
Histone lactylation drives METTL3 upregulation-mediated RNA m6A
modification of CCT2 to hinder CD8+ T cell survival in gastric
cancer. Cell Mol Life Sci. 83:172025. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Zhao Y, Jiang J, Zhou P, Deng K, Liu Z,
Yang M, Yang X, Li J, Li R and Xia J: H3K18 lactylation-mediated
VCAM1 expression promotes gastric cancer progression and metastasis
via AKT-mTOR-CXCL1 axis. Biochem Pharmacol. 222:1161202024.
View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Huang XT, Chen J, Zhu EL, Ma MJ, Yu YY,
Zhu YQ, Ye JY, Xie JZ, Zhao ZY and Yin XY: Positive feedback loop
of histone lactylation-driven HNRNPC promotes autophagy to confer
pancreatic ductal adenocarcinoma gemcitabine resistance. Adv Sci
(Weinh). 13:e104832026. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Fan M, Liu JS, Wei XL, Nie Y and Liu HL:
Histone Lactylation-driven Ubiquitin-specific protease 34 promotes
cisplatin resistance in hepatocellular carcinoma. Gastroenterology
Res. 18:23–30. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Dong R, Fei Y, He Y, Gao P, Zhang B, Zhu
M, Wang Z, Wu L, Wu S, Wang X, et al: Lactylation-driven HECTD2
limits the response of hepatocellular carcinoma to lenvatinib. Adv
Sci (Weinh). 12:e24125592025. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Jia J, Liu N, Zhu X and Chen M: Insights
into recent findings and therapeutic potential of nonhistone
lactylation in cancer. Front Mol Biosci. 12:16616972025. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Li Q, Lin G, Zhang K, Liu X, Li Z, Bing X,
Nie Z, Jin S, Guo J and Min X: Hypoxia exposure induces lactylation
of Axin1 protein to promote glycolysis of esophageal carcinoma
cells. Biochem Pharmacol. 226:1164152024. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Miao Z, Zhao X and Liu X: Hypoxia induced
β-catenin lactylation promotes the cell proliferation and stemness
of colorectal cancer through the wnt signaling pathway. Exp Cell
Res. 422:1134392023. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Liu Z, Yuan J, Su S, Han J, Zeng N, Ma Y,
Chen N and Lv T: AARS1-mediated AKR1B10 lactylation stabilizes an
aerobic glycolysis-positive feedback loop to drive lenvatinib
resistance in hepatocellular carcinoma. Clin Transl Med.
16:e705612026. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Rana MN, Yan S, Cao J, Wang Y and Gao XW:
Lactate promotes mRNA translation in colorectal cancer cells
through eEF2 lactylation. Biochem Biophys Res Commun.
796:1531192026. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Lu Y, Zhu J, Zhang Y, Li W, Xiong Y, Fan
Y, Wu Y, Zhao J, Shang C, Liang H, et al: Lactylation-driven
IGF2BP3-mediated serine metabolism reprogramming and RNA
m6A-modification promotes lenvatinib resistance in HCC. Adv Sci
(Weinh). 11:e24013992024. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Zhu Z, Xia X, Lu Y, Li D, He X, Zhang B,
Xiong G, Zhang W, Liang H and Zhu H: PARK7-driven IGF2BP3-K76
lactylation mediates ferroptosis and HAIC resistance in
hepatocellular carcinoma. Redox Biol. 87:1038692025. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Gong T, Han Q, Zhang Y, Zhu K, Chen Y, Tao
Y, Xing H, Wu D, Ma Y and Zhang S: Matrix stiffness-sensitive LDHA
drives autophagy of pancreatic ductal adenocarcinoma via inducing
FOXO3 expression and lactylation. Biomater Adv. 177:2144012025.
View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Wang X, Li Y, Tang Y, Liu Z, Liu Y, Fu X,
Guo S, Ma J, Ma F, Zhu Z, et al: PD-L1 delactylation-promoted
nuclear translocation accelerates liver cancer growth through
elevating SQLE transcription activity. Cancer Lett. 630:2179012025.
View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Qiu S, Xie B, Liao J, Luo J, Liu X, He L,
Huang Y and Peng L: Blood trace elements in association with
esophageal squamous cell carcinoma risk, aggressiveness and
prognosis in a high incidence region of China. Sci Rep.
15:52082025. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Frankell AM, Jammula S, Li X, Contino G,
Killcoyne S, Abbas S, Perner J, Bower L, Devonshire G, Ococks E, et
al: The landscape of selection in 551 esophageal adenocarcinomas
defines genomic biomarkers for the clinic. Nat Genet. 51:506–516.
2019. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Domper Arnal MJ, Ferrandez Arenas A and
Lanas Arbeloa A: Esophageal cancer: Risk factors, screening and
endoscopic treatment in Western and Eastern countries. World J
Gastroenterol. 21:7933–7943. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Zhang J, Jiang Y, Wu C, Cai S, Wang R,
Zhen Y, Chen S, Zhao K, Huang Y, Luketich J, et al: Comparison of
clinicopathologic features and survival between eastern and western
population with esophageal squamous cell carcinoma. J Thorac Dis.
7:1780–1786. 2015.PubMed/NCBI
|
|
67
|
Yang H, Wang F, Hallemeier CL, Lerut T and
Fu J: Oesophageal cancer. Lancet. 404:1991–2005. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Shah MA, Altorki N, Patel P, Harrison S,
Bass A and Abrams JA: Improving outcomes in patients with
oesophageal cancer. Nat Rev Clin Oncol. 20:390–407. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Li Y, Zhao L and Li XF: Hypoxia and the
tumor microenvironment. Technol Cancer Res Treat.
20:153303382110363042021. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Zeng Y, Zhang J, Xu M, Chen F, Zi R, Yue
J, Zhang Y, Chen N and Chin YE: Roles of mitochondrial serine
hydroxymethyltransferase 2 (SHMT2) in human carcinogenesis. J
Cancer. 12:5888–5894. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Qiao Z, Li Y, Li S, Liu S and Cheng Y:
Hypoxia-induced SHMT2 protein lactylation facilitates glycolysis
and stemness of esophageal cancer cells. Mol Cell Biochem.
479:3063–3076. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Li T, Tong H, Yin H, Luo Y, Zhu J, Qin Z,
Yin S and He W: Starvation induced autophagy promotes the
progression of bladder cancer by LDHA mediated metabolic
reprogramming. Cancer Cell Int. 21:5972021. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Yang Q, Xu D, Yang Y, Lu S, Wang D and
Wang L: Global, Regional, and national burden of gastric cancer in
adolescents and young adults, 1990–2019: A systematic analysis for
the global burden of disease study 2019. Am J Gastroenterol.
119:454–467. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Ma Y, Wang X, Luo Y, Song S, Liang H, Yue
Y and Li W: Symptom cluster assessment tools for gastric cancer
care in China: A comprehensive review. Med Sci Monit.
30:e9444142024. View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Leja M: Where are we with gastric cancer
screening in Europe in 2024? Gut. 73:2074–2082. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Allemani C, Matsuda T, Di Carlo V,
Harewood R, Matz M, Niksic M, Bonaventure A, Valkov M, Johnson CJ,
Esteve J, et al: Global surveillance of trends in cancer survival
2000-14 (CONCORD-3): Analysis of individual records for 37 513 025
patients diagnosed with one of 18 cancers from 322 population-based
registries in 71 countries. Lancet. 391:1023–1075. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Feng F, Tian Y, Xu G, Liu Z, Liu S, Zheng
G, Guo M, Lian X, Fan D and Zhang H: Diagnostic and prognostic
value of CEA, CA19-9, AFP and CA125 for early gastric cancer. BMC
Cancer. 17:7372017. View Article : Google Scholar : PubMed/NCBI
|
|
78
|
Castro C, Peleteiro B and Lunet N:
Modifiable factors and esophageal cancer: A systematic review of
published meta-analyses. J Gastroenterol. 53:37–51. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Kaji S, Irino T, Kusuhara M, Makuuchi R,
Yamakawa Y, Tokunaga M, Tanizawa Y, Bando E, Kawamura T, Kami K, et
al: Metabolomic profiling of gastric cancer tissues identified
potential biomarkers for predicting peritoneal recurrence. Gastric
Cancer. 23:874–883. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Tsvetkov P, Coy S, Petrova B, Dreishpoon
M, Verma A, Abdusamad M, Rossen J, Joesch-Cohen L, Humeidi R,
Spangler RD, et al: Copper induces cell death by targeting
lipoylated TCA cycle proteins. Science. 375:1254–1261. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Springer C, Humayun D and Skouta R:
Cuproptosis: Unraveling the mechanisms of Copper-Induced cell death
and its implication in cancer therapy. Cancers (Basel). 16:6472024.
View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Sun L, Zhang Y, Yang B, Sun S, Zhang P,
Luo Z, Feng T, Cui Z, Zhu T, Li Y, et al: Lactylation of METTL16
promotes cuproptosis via m6A-modification on FDX1 mRNA in gastric
cancer. Nat Commun. 14:65232023. View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Zhao Y, Liu W, Deng K, Chen Y, Zhou P, Liu
C, Jiang G, Wu J, Zhang Y, Qu H, et al: LncRNA BASP1-AS1 drives
PCBP2 K115 lactylation to suppress ferroptosis and confer
oxaliplatin resistance in gastric cancer. Free Radic Biol Med.
240:717–734. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Wrobel P and Ahmed S: Current status of
immunotherapy in metastatic colorectal cancer. Int J Colorectal
Dis. 34:13–25. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Singh D, Luo J, Liu XT, Ma Z, Cheng H, Yu
Y, Yang L and Zhou ZG: The long-term survival benefits of high and
low ligation of inferior mesenteric artery in colorectal cancer
surgery: A review and meta-analysis. Medicine (Baltimore).
96:e85202017. View Article : Google Scholar : PubMed/NCBI
|
|
86
|
Piawah S and Venook AP: Targeted therapy
for colorectal cancer metastases: A review of current methods of
molecularly targeted therapy and the use of tumor biomarkers in the
treatment of metastatic colorectal cancer. Cancer. 125:4139–4147.
2019. View Article : Google Scholar : PubMed/NCBI
|
|
87
|
Wang L, Li S, Luo H, Lu Q and Yu S: PCSK9
promotes the progression and metastasis of colon cancer cells
through regulation of EMT and PI3K/AKT signaling in tumor cells and
phenotypic polarization of macrophages. J Exp Clin Cancer Res.
41:3032022. View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Ferlitsch M, Hassan C, Bisschops R,
Bhandari P, Dinis-Ribeiro M, Risio M, Paspatis GA, Moss A, Libanio
D, Lorenzo-Zuniga V, et al: Colorectal polypectomy and endoscopic
mucosal resection: European Society of Gastrointestinal Endoscopy
(ESGE) Guideline-Update 2024. Endoscopy. 56:516–545. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Argiles G, Tabernero J, Labianca R,
Hochhauser D, Salazar R, Iveson T, Laurent-Puig P, Quirke P,
Yoshino T, Taieb J, et al: Localised colon cancer: ESMO Clinical
Practice Guidelines for diagnosis, treatment and follow-up. Ann
Oncol. 31:1291–1305. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
90
|
Chen Y, Wu J, Zhai L, Zhang T, Yin H, Gao
H, Zhao F, Wang Z, Yang X, Jin M, et al: Metabolic regulation of
homologous recombination repair by MRE11 lactylation. Cell.
187:294–311.e21. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Jin M, Huang B, Yang X, Wang S, Wu J, He
Y, Ding X, Wang X, Wang Z, Yang J, et al: Lactylation of XLF
promotes non-homologous end-joining repair and chemoresistance in
cancer. Mol Cell. 85:2654–2672.e7. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Huang T, Hu C, Chen H, Jiang H, Li T, Tian
Q, He R, Yuan Y, Jiang Y, Zhou Y, et al: Lactylation-driven
NSUN2-mediated RNA m5C modification promotes perineural invasion in
pancreatic cancer. Theranostics. 16:1782–1803. 2026. View Article : Google Scholar : PubMed/NCBI
|
|
93
|
Zhang H, Han Y, Wang J, Wang C, Chang Z,
Xiang J, Hu H, Yuan Z, Zhang N, Wang Y, et al:
Lactylation-stabilized NOL6 promotes colorectal cancer progression
via STAMBP-mediated YY1 deubiquitination and c-Myc transcription
upregulation. Cell Rep. 45:1167742026. View Article : Google Scholar : PubMed/NCBI
|
|
94
|
Deng J, Li Y, Yin L, Liu S, Li Y, Liao W,
Mu L, Luo X and Qin J: Histone lactylation enhances GCLC expression
and thus promotes chemoresistance of colorectal cancer stem cells
through inhibiting ferroptosis. Cell Death Dis. 16:1932025.
View Article : Google Scholar : PubMed/NCBI
|
|
95
|
He J, Li W, Wang S, Lan J, Hong X, Liao L,
Kang D, Wang W, Wang R, Zhang W, et al: Cancer associated
fibroblasts-derived lactate induces oxaliplatin treatment
resistance by promoting cancer stemness via ANTXR1 lactylation in
colorectal cancer. Cancer Lett. 631:2179172025. View Article : Google Scholar : PubMed/NCBI
|
|
96
|
Li XM, Yang Y, Jiang FQ, Hu G, Wan S, Yan
WY, He XS, Xiao F, Yang XM, Guo X, et al: Histone lactylation
inhibits RARgamma expression in macrophages to promote colorectal
tumorigenesis through activation of TRAF6-IL-6-STAT3 signaling.
Cell Rep. 43:1136882024. View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Sung H, Ferlay J, Siegel RL, Laversanne M,
Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020:
GLOBOCAN estimates of incidence and mortality worldwide for 36
cancers in 185 countries. CA Cancer J Clin. 71:209–249.
2021.PubMed/NCBI
|
|
98
|
Kokudo N, Takemura N, Hasegawa K, Takayama
T, Kubo S, Shimada M, Nagano H, Hatano E, Izumi N, Kaneko S, et al:
Clinical practice guidelines for hepatocellular carcinoma: The
Japan Society of Hepatology 2017 (4th JSH-HCC guidelines) 2019
update. Hepatol Res. 49:1109–1113. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
99
|
Liu S, Cai J, Qian X, Zhang J, Zhang Y,
Meng X, Wang M, Gao P and Zhong X: TPX2 lactylation is required for
the cell cycle regulation and hepatocellular carcinoma progression.
Life Sci Alliance. 8:e2024029782025. View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Li L, Dong J, Xu C and Wang S: Lactate
drives senescence-resistant lineages in hepatocellular carcinoma
via histone H2B lactylation of NDRG1. Cancer Lett. 616:2175672025.
View Article : Google Scholar : PubMed/NCBI
|
|
101
|
Cai J, Zhang P, Cai Y, Zhu G, Chen S, Song
L, Du J, Wang B, Dai W, Zhou J, et al: Lactylation-driven NUPR1
promotes immunosuppression of tumor-infiltrating macrophages in
hepatocellular carcinoma. Adv Sci (Weinh). 12:e24130952025.
View Article : Google Scholar : PubMed/NCBI
|
|
102
|
Feng F, Wu J, Chi Q, Wang S, Liu W, Yang
L, Song G, Pan L, Xu K and Wang C: Lactylome analysis unveils
lactylation-dependent mechanisms of stemness remodeling in the
liver cancer stem cells. Adv Sci (Weinh). 11:e24059752024.
View Article : Google Scholar : PubMed/NCBI
|
|
103
|
Wei X, Zou L, Huang Y, Qiu C, Cheng G,
Chen Y and Rao J: LDHA-mediated YAP lactylation promotes the tumor
progression of hepatocellular carcinoma by inducing YAP
dephosphorylation and activation. Biol Direct. 20:642025.
View Article : Google Scholar : PubMed/NCBI
|
|
104
|
Huimin W, Xin W, Shan Y, Junwang Z, Jing
W, Yuan W, Qingtong L, Xiaohui L, Jia Y and Lili Y: Lactate
promotes the epithelial-mesenchymal transition of liver cancer
cells via TWIST1 lactylation. Exp Cell Res. 447:1144742025.
View Article : Google Scholar : PubMed/NCBI
|
|
105
|
Hong H, Han H, Wang L, Cao W, Hu M, Li J,
Wang J, Yang Y, Xu X, Li G, et al: ABCF1-K430-lactylation promotes
HCC malignant progression via transcriptional activation of HIF1
signaling pathway. Cell Death Differ. 32:613–631. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Zeng Y, Jiang H, Chen Z, Xu J, Zhang X,
Cai W, Zeng X, Ma P, Lin R, Yu H, et al: Histone lactylation
promotes multidrug resistance in hepatocellular carcinoma by
forming a positive feedback loop with PTEN. Cell Death Dis.
16:592025. View Article : Google Scholar : PubMed/NCBI
|
|
107
|
Yang T, Zhang S, Nie K, Cheng C, Peng X,
Huo J and Zhang Y: ZNF207-driven PRDX1 lactylation and NRF2
activation in regorafenib resistance and ferroptosis evasion. Drug
Resist Updat. 82:1012742025. View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Bengtsson A, Andersson R and Ansari D: The
actual 5-year survivors of pancreatic ductal adenocarcinoma based
on real-world data. Sci Rep. 10:164252020. View Article : Google Scholar : PubMed/NCBI
|
|
109
|
Conroy T, Hammel P, Hebbar M, Ben
Abdelghani M, Wei AC, Raoul JL, Chone L, Francois E, Artru P, Biagi
JJ, et al: FOLFIRINOX or gemcitabine as adjuvant therapy for
pancreatic cancer. N Engl J Med. 379:2395–2406. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
110
|
Chen M, Cen K, Song Y, Zhang X, Liou YC,
Liu P, Huang J, Ruan J, He J, Ye W, et al:
NUSAP1-LDHA-Glycolysis-Lactate feedforward loop promotes Warburg
effect and metastasis in pancreatic ductal adenocarcinoma. Cancer
Lett. 567:2162852023. View Article : Google Scholar : PubMed/NCBI
|
|
111
|
Zhao R, Yi Y, Liu H, Xu J, Chen S, Wu D,
Wang L and Li F: RHOF promotes Snail1 lactylation by enhancing
PKM2-mediated glycolysis to induce pancreatic cancer cell
endothelial-mesenchymal transition. Cancer Metab. 12:322024.
View Article : Google Scholar : PubMed/NCBI
|
|
112
|
Sun K, Zhang X, Shi J, Huang J, Wang S, Li
X, Lin H, Zhao D, Ye M, Zhang S, et al: Elevated protein
lactylation promotes immunosuppressive microenvironment and
therapeutic resistance in pancreatic ductal adenocarcinoma. J Clin
Invest. 135:e1870242025. View Article : Google Scholar : PubMed/NCBI
|
|
113
|
Liu Y, Liu P, Duan S, Lin J, Qi W, Yu Z,
Gao X, Sun X, Liu J, Lin J, et al: CTCF enhances pancreatic cancer
progression via FLG-AS1-dependent epigenetic regulation and
macrophage polarization. Cell Death Differ. 32:745–762. 2025.
View Article : Google Scholar : PubMed/NCBI
|
|
114
|
Huang Y, Luo G, Peng K, Song Y, Wang Y,
Zhang H, Li J, Qiu X, Pu M, Liu X, et al: Lactylation stabilizes
TFEB to elevate autophagy and lysosomal activity. J Cell Biol.
223:2024. View Article : Google Scholar
|
|
115
|
Shibata S, Sogabe S, Miwa M, Fujimoto T,
Takakura N, Naotsuka A, Kitamura S, Kawamoto T and Soga T:
Identification of the first highly selective inhibitor of human
lactate dehydrogenase B. Sci Rep. 11:213532021. View Article : Google Scholar : PubMed/NCBI
|
|
116
|
Mishra D and Banerjee D: Lactate
dehydrogenases as metabolic links between tumor and stroma in the
tumor microenvironment. Cancers (Basel). 11:7502019. View Article : Google Scholar : PubMed/NCBI
|
|
117
|
Renner O, Mayer M, Leischner C, Burkard M,
Berger A, Lauer UM, Venturelli S and Bischoff SC: Systematic review
of Gossypol/AT-101 in cancer clinical trials. Pharmaceuticals
(Basel). 15:1442022. View Article : Google Scholar : PubMed/NCBI
|
|
118
|
Boudreau A, Purkey HE, Hitz A, Robarge K,
Peterson D, Labadie S, Kwong M, Hong R, Gao M, Del Nagro C, et al:
Metabolic plasticity underpins innate and acquired resistance to
LDHA inhibition. Nat Chem Biol. 12:779–786. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
119
|
Franczak M, Kutryb-Zajac B, El Hassouni B,
Giovannetti E, Granchi C, Minutolo F, Smolenski RT and Peters GJ:
The effect of lactate dehydrogenase-A inhibition on intracellular
nucleotides and mitochondrial respiration in pancreatic cancer
cells. Nucleosides Nucleotides Nucleic Acids. 41:1375–1385. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
120
|
Zhao Z, Han F, Yang S, Wu J and Zhan W:
Oxamate-mediated inhibition of lactate dehydrogenase induces
protective autophagy in gastric cancer cells: Involvement of the
Akt-mTOR signaling pathway. Cancer Lett. 358:17–26. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
121
|
Sun N, Kabir M, Lee Y, Xie L, Hu X, Velez
J, Chen X, Kaniskan HU and Jin J: Discovery of the first lactate
dehydrogenase proteolysis targeting chimera degrader for the
treatment of pancreatic cancer. J Med Chem. 66:596–610. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
122
|
Oshima N, Ishida R, Kishimoto S, Beebe K,
Brender JR, Yamamoto K, Urban D, Rai G, Johnson MS, Benavides G, et
al: Dynamic Imaging of LDH inhibition in tumors reveals rapid in
vivo metabolic rewiring and vulnerability to combination therapy.
Cell Rep. 30:1798–1810.e4. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
123
|
Mazzio E, Mack N, Badisa RB and Soliman
KFA: Triple isozyme lactic acid dehydrogenase inhibition in fully
viable MDA-MB-231 cells induces cytostatic effects that are not
reversed by exogenous lactic acid. Biomolecules. 11:17512021.
View Article : Google Scholar : PubMed/NCBI
|
|
124
|
Yang H, Zhou P, Huang H, Chen D, Ma N, Cui
QC, Shen S, Dong W, Zhang X, Lian W, et al: Shikonin exerts
antitumor activity via proteasome inhibition and cell death
induction in vitro and in vivo. Int J Cancer. 124:2450–2459. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
125
|
Yang P, Ding GB, Liu W, Fu R, Sajid A and
Li Z: Tannic acid directly targets pyruvate kinase isoenzyme M2 to
attenuate colon cancer cell proliferation. Food Funct. 9:5547–5559.
2018. View Article : Google Scholar : PubMed/NCBI
|
|
126
|
Shan S, Shi J, Yang P, Jia B, Wu H, Zhang
X and Li Z: Apigenin restrains colon cancer cell proliferation via
targeted blocking of pyruvate kinase M2-Dependent glycolysis. J
Agric Food Chem. 65:8136–8144. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
127
|
Wu H, Du J, Li C, Li H, Guo H and Li Z:
Kaempferol can reverse the 5-Fu resistance of colorectal cancer
cells by inhibiting PKM2-Mediated glycolysis. Int J Mol Sci.
23:35442022. View Article : Google Scholar : PubMed/NCBI
|
|
128
|
Li W, Qiu Y, Hao J, Zhao C, Deng X and Shu
G: Dauricine upregulates the chemosensitivity of hepatocellular
carcinoma cells: Role of repressing glycolysis via miR-199a:
HK2/PKM2 modulation. Food Chem Toxicol. 121:156–165. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
129
|
Ciombor K, Whisenant J, Cardin D, Goff L,
Das S, Schulte M, Cohen A, Coffey R, Ayers G, Krumsick R, et al:
CB-839, panitumumab, and irinotecan in RAS wildtype (WT) metastatic
colorectal cancer (mCRC): Phase I results. J Clin Oncol. 37:574.
2019. View Article : Google Scholar
|
|
130
|
Yeh TK, Kuo CC, Lee YZ, Ke YY, Chu KF, Hsu
HY, Chang HY, Liu YW, Song JS, Yang CW, et al: Design, synthesis,
and evaluation of thiazolidine-2,4-dione derivatives as a novel
class of glutaminase inhibitors. J Med Chem. 60:5599–5612. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
131
|
Nishi K, Suzuki M, Yamamoto N, Matsumoto
A, Iwase Y, Yamasaki K, Otagiri M and Yumita N: Glutamine
deprivation enhances Acetyl-CoA carboxylase Inhibitor-induced death
of human pancreatic cancer cells. Anticancer Res. 38:6683–6689.
2018. View Article : Google Scholar : PubMed/NCBI
|
|
132
|
Kitayama K, Yashiro M, Morisaki T, Miki Y,
Okuno T, Kinoshita H, Fukuoka T, Kasashima H, Masuda G, Hasegawa T,
et al: Pyruvate kinase isozyme M2 and glutaminase might be
promising molecular targets for the treatment of gastric cancer.
Cancer Sci. 108:2462–2469. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
133
|
Chen X, Zhang F, Lu C, Wu R, Yang B, Liao
T, Du B, Wu F, Ding J, Fang S, et al: Lactate-fueled theranostic
nanoplatforms for enhanced MRI-guided ferroptosis synergistic with
immunotherapy of hepatocellular carcinoma. ACS Appl Mater
Interfaces. 17:9155–9172. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
134
|
Chen Y, Bei J, Chen M, Cai W, Zhou Z, Cai
M, Huang W, Lin L, Guo Y, Liu M, et al: Intratumoral lactate
depletion based on injectable Nanoparticles-hydrogel composite
system synergizes with immunotherapy against postablative
hepatocellular carcinoma recurrence. Adv Healthc Mater.
13:e23030312024. View Article : Google Scholar : PubMed/NCBI
|
|
135
|
Sui X, Zhou H and Wang T: GLUT1 maintains
esophageal cancer stem cell-like characteristics by inhibiting
autophagy-dependent ferroptosis via EGFR. Exp Cell Res.
449:1146002025. View Article : Google Scholar : PubMed/NCBI
|
|
136
|
Hayashi M, Nakamura K, Harada S, Tanaka M,
Kobayashi A, Saito H, Tsuji T, Yamamoto D, Moriyama H, Kinoshita J,
et al: GLUT1 inhibition by BAY-876 induces metabolic changes and
cell death in human colorectal cancer cells. BMC Cancer.
25:7162025. View Article : Google Scholar : PubMed/NCBI
|
|
137
|
Dong F, He K, Zhang S, Song K, Jiang L, Hu
LP, Li Q, Zhang XL, Zhang N, Li BT, et al: SSRI antidepressant
citalopram reverses the Warburg effect to inhibit hepatocellular
carcinoma by directly targeting GLUT1. Cell Rep. 43:1148182024.
View Article : Google Scholar : PubMed/NCBI
|
|
138
|
Liu W, Fang Y, Wang XT, Liu J, Dan X and
Sun LL: Overcoming 5-Fu resistance of colon cells through
inhibition of Glut1 by the specific inhibitor WZB117. Asian Pac J
Cancer Prev. 15:7037–7041. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
139
|
Brito AF, Ribeiro M, Abrantes AM, Mamede
AC, Laranjo M, Casalta-Lopes JE, Goncalves AC, Sarmento-Ribeiro AB,
Tralhao JG and Botelho MF: New approach for treatment of primary
liver tumors: The role of quercetin. Nutr Cancer. 68:250–266. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
140
|
Li C, Noonan AM, Hays J, Roychowdhury S,
Malalur P, Elkhatib R, Manne A, Mittra A, Rahman S, Yan L, et al:
Riluzole in Combination with mFOLFOX6 and bevacizumab in treating
patients with metastatic colorectal cancer: A phase I clinical
trial. Clin Cancer Res. 31:2115–2123. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
141
|
Li C, Noonan A, Hays J, Roychowdhury S,
Malalur P, Elkhatib R, Manne A, Mittra A, Rahman S, Phelps M, et
al: A phase I clinical trial of riluzole in combination with
mFOLFOX6 and bevacizumab in treating patients with metastatic
colorectal cancer. J Clin Oncol. 42:101. 2024. View Article : Google Scholar
|
|
142
|
Wlodarczyk J, Wlodarczyk M, Zielinska M,
Jedrzejczak B, Dziki L and Fichna J: Blockade of fructose
transporter protein GLUT5 inhibits proliferation of colon cancer
cells: Proof of concept for a new class of anti-tumor therapeutics.
Pharmacol Rep. 73:939–945. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
143
|
Blaszczak W, Williams H and Swietach P:
Autoregulation of H+/lactate efflux prevents monocarboxylate
transport (MCT) inhibitors from reducing glycolytic lactic acid
production. Br J Cancer. 127:1365–1377. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
144
|
Alobaidi B, Hashimi SM, Alqosaibi AI,
AlQurashi N and Alhazmi S: Targeting the monocarboxylate
transporter MCT2 and lactate dehydrogenase A LDHA in cancer cells
with FX-11 and AR-C155858 inhibitors. Eur Rev Med Pharmacol Sci.
27:6605–6617. 2023.PubMed/NCBI
|
|
145
|
Shim CK, Cheon EP, Kang KW, Seo KS and Han
HK: Inhibition effect of flavonoids on monocarboxylate transporter
1 (MCT1) in Caco-2 cells. J Pharm Pharmacol. 59:1515–1519. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
146
|
Rincon-Torroella J, Dal Molin M, Mog B,
Han G, Watson E, Wyhs N, Ishiyama S, Ahmedna T, Minn I, Azad N, et
al: ME3BP-7 is a targeted cytotoxic agent that rapidly kills
pancreatic cancer cells expressing high levels of monocarboxylate
transporter MCT1. Elife. 13:RP944882025. View Article : Google Scholar : PubMed/NCBI
|
|
147
|
Fang Y, Liu W, Tang Z, Ji X, Zhou Y, Song
S, Tian M, Tao C, Huang R, Zhu G, et al: Monocarboxylate
transporter 4 inhibition potentiates hepatocellular carcinoma
immunotherapy through enhancing T cell infiltration and immune
attack. Hepatology. 77:109–123. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
148
|
Goreczny G, Escobedo J and Sandanayaka V:
Abstract 1335: Dual MCT1/4 inhibition promotes anti-tumor immunity
in triple-negative breast cancer. Cancer Res. 81:13352021.
View Article : Google Scholar
|
|
149
|
Blackhall F: O11.5-Activity of the
monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung
cancer. Ann Oncol. 26:ii152015. View Article : Google Scholar
|
|
150
|
Benjamin D, Robay D, Hindupur SK, Pohlmann
J, Colombi M, El-Shemerly MY, Maira SM, Moroni C, Lane HA and Hall
MN: Dual inhibition of the lactate transporters MCT1 and MCT4 is
synthetic lethal with metformin due to NAD+ depletion in cancer
cells. Cell Rep. 25:3047–3058.e4. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
151
|
Wu S, Xu L, He C, Wang P, Qin J, Guo F and
Wang Y: Lactate efflux inhibition by Syrosingopine/LOD Co-Loaded
nanozyme for synergetic Self-Replenishing catalytic cancer therapy
and immune microenvironment remodeling. Adv Sci (Weinh).
10:e23006862023. View Article : Google Scholar : PubMed/NCBI
|
|
152
|
Draoui N, Schicke O, Seront E, Bouzin C,
Sonveaux P, Riant O and Feron O: Antitumor activity of
7-aminocarboxycoumarin derivatives, a new class of potent
inhibitors of lactate influx but not efflux. Mol Cancer Ther.
13:1410–1418. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
153
|
Halford S, Veal GJ, Wedge SR, Payne GS,
Bacon CM, Sloan P, Dragoni I, Heinzmann K, Potter S, Salisbury BM,
et al: A phase I dose-escalation study of AZD3965, an oral
monocarboxylate transporter 1 inhibitor, in patients with advanced
cancer. Clin Cancer Res. 29:1429–1439. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
154
|
Curtis NJ, Mooney L, Hopcroft L,
Michopoulos F, Whalley N, Zhong H, Murray C, Logie A, Revill M,
Byth KF, et al: Pre-clinical pharmacology of AZD3965, a selective
inhibitor of MCT1: DLBCL, NHL and Burkitt's lymphoma anti-tumor
activity. Oncotarget. 8:69219–69236. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
155
|
Quanz M, Bender E, Kopitz C, Grünewald S,
Schlicker A, Schwede W, Eheim A, Toschi L, Neuhaus R, Richter C, et
al: Preclinical efficacy of the novel monocarboxylate transporter 1
inhibitor BAY-8002 and associated markers of resistance. Mol Cancer
Ther. 17:2285–2296. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
156
|
Yang J, Yu X, Xiao M, Xu H, Tan Z, Lei Y,
Guo Y, Wang W, Xu J, Shi S, et al: Histone lactylation-driven
feedback loop modulates cholesterol-linked immunosuppression in
pancreatic cancer. Gut. 74:1859–1872. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
157
|
Huang T, You Q, Liu J, Shen X, Huang D,
Tao X, He Z, Wu C, Xi X, Yu S, et al: WTAP Mediated m6A
modification stabilizes PDIA3P1 and promotes tumor progression
driven by histone lactylation in esophageal squamous cell
carcinoma. Adv Sci (Weinh). 12:e065292025. View Article : Google Scholar : PubMed/NCBI
|
|
158
|
Pan L, Feng F, Wu J, Fan S, Han J, Wang S,
Yang L, Liu W, Wang C and Xu K: Demethylzeylasteral targets lactate
by inhibiting histone lactylation to suppress the tumorigenicity of
liver cancer stem cells. Pharmacol Res. 181:1062702022. View Article : Google Scholar : PubMed/NCBI
|
|
159
|
Gong H, Xu HM, Ma YH and Zhang DK:
Demethylzeylasteral targets lactate to suppress the tumorigenicity
of liver cancer stem cells: It is attributed to histone
lactylation? Pharmacol Res. 194:1068692023. View Article : Google Scholar : PubMed/NCBI
|
|
160
|
Xu H, Li L, Wang S, Wang Z, Qu L, Wang C
and Xu K: Royal jelly acid suppresses hepatocellular carcinoma
tumorigenicity by inhibiting H3 histone lactylation at H3K9la and
H3K14la sites. Phytomedicine. 118:1549402023. View Article : Google Scholar : PubMed/NCBI
|
|
161
|
Liu P, Ji H and Li F: MRE11 lactylation: A
linker between Warburg effect and DNA repair. Life Metab.
3:loae0132024. View Article : Google Scholar : PubMed/NCBI
|
|
162
|
Xie B, Zhang M, Li J, Cui J, Zhang P, Liu
F, Wu Y, Deng W, Ma J, Li X, et al: KAT8-catalyzed lactylation
promotes eEF1A2-mediated protein synthesis and colorectal
carcinogenesis. Proc Natl Acad Sci USA. 121:e23141281212024.
View Article : Google Scholar : PubMed/NCBI
|
|
163
|
de Talhouët C, Esteras N, Soutar MPM,
O'Callaghan B and Plun-Favreau H: KAT8 compound inhibition inhibits
the initial steps of PINK1-dependant mitophagy. Sci Rep.
14:117212024. View Article : Google Scholar : PubMed/NCBI
|
|
164
|
Yang Z, Su W, Zhang Q, Niu L, Feng B,
Zhang Y, Huang F, He J, Zhou Q, Zhou X, et al: Lactylation of HDAC1
confers resistance to ferroptosis in colorectal cancer. Adv Sci
(Weinh). 12:e24088452025. View Article : Google Scholar : PubMed/NCBI
|
|
165
|
Liu R, Wu J, Guo H, Yao W, Li S, Lu Y, Jia
Y, Liang X, Tang J and Zhang H: Post-translational modifications of
histones: Mechanisms, biological functions, and therapeutic
targets. MedComm (2020). 4:e2922023. View Article : Google Scholar : PubMed/NCBI
|
|
166
|
Wan N, Wang N, Yu S, Zhang H, Tang S, Wang
D, Lu W, Li H, Delafield DG, Kong Y, et al: Cyclic immonium ion of
lactyllysine reveals widespread lactylation in the human proteome.
Nat methods. 19:854–864. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
167
|
Sun Y, Chen Y and Peng T: A bioorthogonal
chemical reporter for the detection and identification of protein
lactylation. Chem Sci. 13:6019–6027. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
168
|
Wan L, Zhang H, Liu J, He Q, Zhao J, Pan
C, Zheng K and Tang Y: Lactylation and human disease. Expert Rev
Mol Med. 27:e102025. View Article : Google Scholar : PubMed/NCBI
|
|
169
|
Wang S and Zhang L: Stereospecific
lactylation in bacteriology: L/D-lactate partitioning shapes host
metabolic-disease axis. Front Microbiol. 16:16937002025. View Article : Google Scholar : PubMed/NCBI
|
|
170
|
Paulino da Silva Filho O, Ali M, Nabbefeld
R, Primavessy D, Bovee-Geurts PH, Grimm S, Kirchner A, Wiesmuller
KH, Schneider M, Walboomers XF and Brock R: A comparison of
acyl-moieties for noncovalent functionalization of PLGA and
PEG-PLGA nanoparticles with a cell-penetrating peptide. RSC Adv.
11:36116–36124. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
171
|
Wang Z, Hao D, Zhao S, Zhang Z, Zeng Z and
Wang X: Lactate and lactylation: Clinical applications of routine
carbon source and novel modification in human diseases. Mol Cell
Proteomics. 22:1006412023. View Article : Google Scholar : PubMed/NCBI
|
|
172
|
Batsios G, Taglang C, Udutha S, Gillespie
AM, Phoenix T, Mueller S, Venneti S, Koschmann C and Viswanath P:
Lactylation fuels nucleotide biosynthesis and facilitates deuterium
metabolic imaging of tumor proliferation in preclinical models of
H3K27M-mutant gliomas. Sci Transl Med. 18:eadw08342026. View Article : Google Scholar : PubMed/NCBI
|
|
173
|
Sun X, Dong H, Su R, Chen J, Li W, Yin S
and Zhang C: Lactylation-related gene signature accurately predicts
prognosis and immunotherapy response in gastric cancer. Front
Oncol. 14:14855802024. View Article : Google Scholar : PubMed/NCBI
|
|
174
|
Hua M and Li T: Multiomic machine learning
on lactylation for molecular typing and prognosis of lung
adenocarcinoma. Sci Rep. 15:30752025. View Article : Google Scholar : PubMed/NCBI
|
