Adrenal lymphoma with hypertension: A report of three cases

Tan,Kunlei; Han,Zhijun; Zhou,Yali; Tan,Miduo; Chen,Lei; Deng,Yinchun

doi:10.3892/ol.2026.15685

August-2026 Volume 32 Issue 2

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August-2026 Volume 32 Issue 2

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Case Report Open Access

Adrenal lymphoma with hypertension: A report of three cases

Authors:
- Kunlei Tan
- Zhijun Han
- Yali Zhou
- Miduo Tan
- Lei Chen
- Yinchun Deng
View Affiliations / Copyright

Affiliations: Department of Urology, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan 412000, P.R. China, Department of Neonatology, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan 412000, P.R. China, Department of Breast Surgery, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan 412000, P.R. China, First Department of Colorectal and Anal Surgery, Digestive Disease Medical Center Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan 412000, P.R. China

Copyright: © Tan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 330
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Published online on: June 5, 2026

https://doi.org/10.3892/ol.2026.15685
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Abstract

Adrenal lymphoma is a rare clinical entity, classified as either primary adrenal lymphoma (PAL) or secondary adrenal lymphoma. PAL is a highly aggressive malignancy with an extremely low incidence rate. To date, <250 cases have been reported in the English literature. The clinical manifestations of PAL are diverse and non‑specific, often resulting in a delayed diagnosis or a misdiagnosis. In patients with comorbid hypertension, the differential diagnosis of an adrenal mass typically emphasizes functional tumors, such as aldosterone‑producing tumors (which cause primary aldosteronism) and pheochromocytoma. Due to the usual absence of characteristic hormonal abnormalities, PAL is frequently overlooked in clinical practice. The present report describes the cases of 3 male patients with PAL, aged 83, 73 and 63 years. The first 2 patients had pre‑existing hypertension prior to the confirmation of PAL. The present report summarizes the diagnostic strategies for PAL and relevant differential diagnoses, and describes the treatment responses observed in each case. Diagnosing PAL is challenging, and its prognosis is generally poor. PAL should be considered in the differential diagnosis of adrenal masses, particularly in patients with a history of hypertension. Once diagnosed, management should be guided by a multidisciplinary team specialized in adrenal and hematological disorders.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Adrenal lymphoma with hypertension: A report of three cases

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