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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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August-2026 Volume 32 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Case Report Open Access

Long survival of PD‑L1‑positive mediastinal sarcomatoid carcinoma after immunotherapy and anti‑angiogenic target therapy: A case report

  • Authors:
    • Shuling Wu
    • Danping Wang
    • Qiong Fu
    • Yingying Ding

  • View Affiliations / Copyright

    Affiliations: Department of Respiratory and Critical Care Medicine, The First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang 311200, P.R. China, Department of Pathology, The First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang 311200, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 335
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    Published online on: June 11, 2026
       https://doi.org/10.3892/ol.2026.15690
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Abstract

Mediastinal sarcomatoid carcinoma (SC) is rare and is often associated with poor survival outcomes. At present, there have been no investigations into the use of immunotherapy and anti‑angiogenic target therapy to treat mediastinal SC. In the present study, a 74‑year‑old woman with mediastinal SC who achieved long‑term survival was described. Immunohistochemistry of tumor specimens showed high expression of programmed cell death ligand 1 (PD‑L1) and a combined positive score of 80. The patient initially received two cycles of chemotherapy and one cycle of radiotherapy combined with anlotinib; subsequent evaluation confirmed stable disease. After which, the patient received two cycles of immunotherapy with durvalumab, and received continued administration with anlotinib; follow‑up evaluation revealed a partial response. Immunotherapy was halted due to severe adverse effects, but treatment with anlotinib has remained ongoing. At present, the patient remains alive with no evidence of disease progression, achieving a progression‑free survival of >42 months. The present case report highlights the potential of immunotherapy combined with anti‑angiogenic targeted therapy in treating PD‑L1‑positive mediastinal SC, despite the life‑threatening adverse reactions, offering a viable treatment option for similar clinical cases.

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Copy and paste a formatted citation
Spandidos Publications style
Wu S, Wang D, Fu Q and Ding Y: Long survival of PD‑L1‑positive mediastinal sarcomatoid carcinoma after immunotherapy and anti‑angiogenic target therapy: A case report. Oncol Lett 32: 335, 2026.
APA
Wu, S., Wang, D., Fu, Q., & Ding, Y. (2026). Long survival of PD‑L1‑positive mediastinal sarcomatoid carcinoma after immunotherapy and anti‑angiogenic target therapy: A case report. Oncology Letters, 32, 335. https://doi.org/10.3892/ol.2026.15690
MLA
Wu, S., Wang, D., Fu, Q., Ding, Y."Long survival of PD‑L1‑positive mediastinal sarcomatoid carcinoma after immunotherapy and anti‑angiogenic target therapy: A case report". Oncology Letters 32.2 (2026): 335.
Chicago
Wu, S., Wang, D., Fu, Q., Ding, Y."Long survival of PD‑L1‑positive mediastinal sarcomatoid carcinoma after immunotherapy and anti‑angiogenic target therapy: A case report". Oncology Letters 32, no. 2 (2026): 335. https://doi.org/10.3892/ol.2026.15690
Copy and paste a formatted citation
x
Spandidos Publications style
Wu S, Wang D, Fu Q and Ding Y: Long survival of PD‑L1‑positive mediastinal sarcomatoid carcinoma after immunotherapy and anti‑angiogenic target therapy: A case report. Oncol Lett 32: 335, 2026.
APA
Wu, S., Wang, D., Fu, Q., & Ding, Y. (2026). Long survival of PD‑L1‑positive mediastinal sarcomatoid carcinoma after immunotherapy and anti‑angiogenic target therapy: A case report. Oncology Letters, 32, 335. https://doi.org/10.3892/ol.2026.15690
MLA
Wu, S., Wang, D., Fu, Q., Ding, Y."Long survival of PD‑L1‑positive mediastinal sarcomatoid carcinoma after immunotherapy and anti‑angiogenic target therapy: A case report". Oncology Letters 32.2 (2026): 335.
Chicago
Wu, S., Wang, D., Fu, Q., Ding, Y."Long survival of PD‑L1‑positive mediastinal sarcomatoid carcinoma after immunotherapy and anti‑angiogenic target therapy: A case report". Oncology Letters 32, no. 2 (2026): 335. https://doi.org/10.3892/ol.2026.15690
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