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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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August-2026 Volume 32 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

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Case Report Open Access

Safe management of sequential chemotherapy in a hemodialysis patient with metastatic colorectal cancer: A case report

  • Authors:
    • Rika Sasaki
    • Nobuhito Hara
    • Yoshiki Kojitani
    • Yumi Yoshii
    • Masahide Ota
    • Shunsuke Okazaki
    • Masayuki Takeda

  • View Affiliations / Copyright

    Affiliations: Department of Cancer Genomics and Medical Oncology, Nara Medical University, Kashihara, Nara 634‑8521, Japan
    Copyright: © Sasaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 358
    |
    Published online on: June 18, 2026
       https://doi.org/10.3892/ol.2026.15714
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Abstract

Managing chemotherapy in hemodialysis (HD) patients is clinically challenging due to altered pharmacokinetics and a higher risk of severe toxicity. Evidence on drug selection and dose titration in cancer patients undergoing HD is limited. The present study reported the case of a patient with metastatic colorectal cancer who safely received first‑to third‑line chemotherapy while on maintenance HD. Treatment was individualized based on drug characteristics and the dialysis schedule. Initial therapy consisted of reduced‑dose capecitabine (1,000 mg/m2/day, days 1‑14) plus oxaliplatin (70 mg/m2, day 1) in a 21‑day cycle, which was administered for 2 cycles. This was followed by 14 cycles of irinotecan monotherapy (day 1 of a 14‑day cycle); the dose was initiated at 120 mg/m2 and gradually reduced to 105 mg/m2 and then 90 mg/m2 based on toxicity. Third‑line treatment involved 5 cycles of regorafenib (days 1‑21 of a 28‑day cycle), which was initiated at 40 mg/day and increased to 80 mg/day after confirming safety and tolerability. No life‑threatening adverse events occurred during the treatment course. This case suggests that chemotherapy can be administered safely in selected HD patients when treatment is individualized, taking into account drug characteristics, dialysis‑related factors and patient tolerance.

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Copy and paste a formatted citation
Spandidos Publications style
Sasaki R, Hara N, Kojitani Y, Yoshii Y, Ota M, Okazaki S and Takeda M: Safe management of sequential chemotherapy in a hemodialysis patient with metastatic colorectal cancer: A case report. Oncol Lett 32: 358, 2026.
APA
Sasaki, R., Hara, N., Kojitani, Y., Yoshii, Y., Ota, M., Okazaki, S., & Takeda, M. (2026). Safe management of sequential chemotherapy in a hemodialysis patient with metastatic colorectal cancer: A case report. Oncology Letters, 32, 358. https://doi.org/10.3892/ol.2026.15714
MLA
Sasaki, R., Hara, N., Kojitani, Y., Yoshii, Y., Ota, M., Okazaki, S., Takeda, M."Safe management of sequential chemotherapy in a hemodialysis patient with metastatic colorectal cancer: A case report". Oncology Letters 32.2 (2026): 358.
Chicago
Sasaki, R., Hara, N., Kojitani, Y., Yoshii, Y., Ota, M., Okazaki, S., Takeda, M."Safe management of sequential chemotherapy in a hemodialysis patient with metastatic colorectal cancer: A case report". Oncology Letters 32, no. 2 (2026): 358. https://doi.org/10.3892/ol.2026.15714
Copy and paste a formatted citation
x
Spandidos Publications style
Sasaki R, Hara N, Kojitani Y, Yoshii Y, Ota M, Okazaki S and Takeda M: Safe management of sequential chemotherapy in a hemodialysis patient with metastatic colorectal cancer: A case report. Oncol Lett 32: 358, 2026.
APA
Sasaki, R., Hara, N., Kojitani, Y., Yoshii, Y., Ota, M., Okazaki, S., & Takeda, M. (2026). Safe management of sequential chemotherapy in a hemodialysis patient with metastatic colorectal cancer: A case report. Oncology Letters, 32, 358. https://doi.org/10.3892/ol.2026.15714
MLA
Sasaki, R., Hara, N., Kojitani, Y., Yoshii, Y., Ota, M., Okazaki, S., Takeda, M."Safe management of sequential chemotherapy in a hemodialysis patient with metastatic colorectal cancer: A case report". Oncology Letters 32.2 (2026): 358.
Chicago
Sasaki, R., Hara, N., Kojitani, Y., Yoshii, Y., Ota, M., Okazaki, S., Takeda, M."Safe management of sequential chemotherapy in a hemodialysis patient with metastatic colorectal cancer: A case report". Oncology Letters 32, no. 2 (2026): 358. https://doi.org/10.3892/ol.2026.15714
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