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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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September-2026 Volume 32 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Review Open Access

Role of long non‑coding RNA HCG11 in human cancers: From molecular mechanisms to clinical applications (Review)

  • Authors:
    • Qiong-Feng Tan
    • Bo Chen
    • Hai-Feng Hu
    • Huang Liu
    • Wen Huang
    • Wei Mu

  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The Second People's Hospital of China Three Gorges University, Yichang, Hubei 443000, P.R. China, Department of Gastroenterology, The Second People's Hospital of China Three Gorges University, Yichang, Hubei 443000, P.R. China, Department of Integrated Traditional Chinese and Western Medicine Oncology, The Second People's Hospital of China Three Gorges University, Yichang, Hubei 443000, P.R. China, Department of Traditional Chinese Medicine, The Second People's Hospital of China Three Gorges University, Yichang, Hubei 443000, P.R. China
    Copyright: © Tan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 390
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    Published online on: July 3, 2026
       https://doi.org/10.3892/ol.2026.15745
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Abstract

Long non‑coding RNAs (lncRNAs) are transcripts >200 nucleotides in length that have no protein‑coding potential and are important regulators of tumor development. Among them, HLA complex group 11 (HCG11) is a newly discovered lncRNA encoded by a gene located on chromosome 6p22.2, which consists of one exon. In recent years, interest in target molecules has increased because of their dysregulated expression in a number of cancers and their notable association with clinicopathological variables. Growing evidence has indicated that HCG11 is involved in tumor development mainly through interactions with target proteins, the sequestration of microRNAs and the participation of the MAPK, PI3K/AKT and Notch/hairy and enhancer of split‑1 pathways. Together, the molecular mechanisms involved in the malignant tumor phenotype include proliferation, invasion, migration, apoptosis, cell cycle, drug resistance and epithelial‑mesenchymal transition. The expression of HCG11 is closely related to tumor grade, differentiation, TNM stage, lymph node metastasis and prognosis. The present review provides an overview of the abnormal expression pattern, molecular mechanism and clinical relevance of HCG11 in malignant tumors. HCG11 has potential for use as a diagnostic biomarker and a therapeutic target for cancer treatment.

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Copy and paste a formatted citation
Spandidos Publications style
Tan Q, Chen B, Hu H, Liu H, Huang W and Mu W: Role of long non‑coding RNA HCG11 in human cancers: From molecular mechanisms to clinical applications (Review). Oncol Lett 32: 390, 2026.
APA
Tan, Q., Chen, B., Hu, H., Liu, H., Huang, W., & Mu, W. (2026). Role of long non‑coding RNA HCG11 in human cancers: From molecular mechanisms to clinical applications (Review). Oncology Letters, 32, 390. https://doi.org/10.3892/ol.2026.15745
MLA
Tan, Q., Chen, B., Hu, H., Liu, H., Huang, W., Mu, W."Role of long non‑coding RNA HCG11 in human cancers: From molecular mechanisms to clinical applications (Review)". Oncology Letters 32.3 (2026): 390.
Chicago
Tan, Q., Chen, B., Hu, H., Liu, H., Huang, W., Mu, W."Role of long non‑coding RNA HCG11 in human cancers: From molecular mechanisms to clinical applications (Review)". Oncology Letters 32, no. 3 (2026): 390. https://doi.org/10.3892/ol.2026.15745
Copy and paste a formatted citation
x
Spandidos Publications style
Tan Q, Chen B, Hu H, Liu H, Huang W and Mu W: Role of long non‑coding RNA HCG11 in human cancers: From molecular mechanisms to clinical applications (Review). Oncol Lett 32: 390, 2026.
APA
Tan, Q., Chen, B., Hu, H., Liu, H., Huang, W., & Mu, W. (2026). Role of long non‑coding RNA HCG11 in human cancers: From molecular mechanisms to clinical applications (Review). Oncology Letters, 32, 390. https://doi.org/10.3892/ol.2026.15745
MLA
Tan, Q., Chen, B., Hu, H., Liu, H., Huang, W., Mu, W."Role of long non‑coding RNA HCG11 in human cancers: From molecular mechanisms to clinical applications (Review)". Oncology Letters 32.3 (2026): 390.
Chicago
Tan, Q., Chen, B., Hu, H., Liu, H., Huang, W., Mu, W."Role of long non‑coding RNA HCG11 in human cancers: From molecular mechanisms to clinical applications (Review)". Oncology Letters 32, no. 3 (2026): 390. https://doi.org/10.3892/ol.2026.15745
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