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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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October-2026 Volume 32 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Accuracy of percutaneous ultrasound‑guided needle biopsy of abdominal lymph nodes for the diagnosis of malignant disease

  • Authors:
    • Camilla Mazzoni
    • Lisa Argnani
    • Davide Di Benedetto
    • Sofia Maria Bakken
    • Beatrice Casadei
    • Cinzia Pellegrini
    • Leonardo De Marco
    • Marta Machado
    • Alessandro Broccoli
    • Pier Luigi Zinzani
    • Carla Serra

  • View Affiliations / Copyright

    Affiliations: Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliero‑Universitaria di Bologna, ‘Seràgnoli’ Institute of Hematology, 40138 Bologna, Italy, Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy, Diagnostic and Therapeutic Interventional Ultrasound Unit, IRCCS Azienda Ospedaliero‑Universitaria di Bologna, 40138 Bologna, Italy, General Medicine C, Department of Medicine, University of Verona, Azienda Ospedaliera Universitaria Integrata Verona, 37134 Verona, Italy
  • Article Number: 439
    |
    Published online on: August 3, 2026
       https://doi.org/10.3892/ol.2026.15794
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Abstract

The differential diagnosis of suspected neoplastic disease involving deep lymph nodes remains challenging, particularly in the abdomen, where biopsies are technically more complex and associated with higher procedural risks. The present retrospective single‑center study aimed to evaluate the feasibility, safety and diagnostic accuracy of ultrasound‑guided needle biopsy in patients with neoplastic disease of deep abdominal lymph nodes. A total of 77 abdominal lymph node biopsies were analyzed. Among them, 15 (19.5%) were non‑diagnostic. Of the remaining 62 diagnostic biopsies, 40 (64.5%) were lymphomas, 17 (27.4%) were solid tumors, and 5 (8.1%) were non‑neoplastic conditions. Among the 57 biopsies positive for neoplastic disease, 32 of 40 (80.0%) lymphomas and six of 17 (35.3%) solid tumors represented new diagnoses, while the remaining cases were histologically confirmed. No procedure‑related adverse events were observed. The sensitivity, specificity, positive predictive value and negative predictive value were 100, 83.3, 98.2 and 100%, respectively. The overall diagnostic yield was 80.5%, and the diagnostic accuracy reached 98.4%. US‑NB could represent an accurate and reliable diagnostic tool for evaluating suspected neoplastic disease of deep abdominal lymph nodes, both at initial diagnosis and at relapse, offering a favorable safety profile and high diagnostic performance.

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Copy and paste a formatted citation
Spandidos Publications style
Mazzoni C, Argnani L, Di Benedetto D, Bakken SM, Casadei B, Pellegrini C, De Marco L, Machado M, Broccoli A, Zinzani PL, Zinzani PL, et al: Accuracy of percutaneous ultrasound‑guided needle biopsy of abdominal lymph nodes for the diagnosis of malignant disease. Oncol Lett 32: 439, 2026.
APA
Mazzoni, C., Argnani, L., Di Benedetto, D., Bakken, S.M., Casadei, B., Pellegrini, C. ... Serra, C. (2026). Accuracy of percutaneous ultrasound‑guided needle biopsy of abdominal lymph nodes for the diagnosis of malignant disease. Oncology Letters, 32, 439. https://doi.org/10.3892/ol.2026.15794
MLA
Mazzoni, C., Argnani, L., Di Benedetto, D., Bakken, S. M., Casadei, B., Pellegrini, C., De Marco, L., Machado, M., Broccoli, A., Zinzani, P. L., Serra, C."Accuracy of percutaneous ultrasound‑guided needle biopsy of abdominal lymph nodes for the diagnosis of malignant disease". Oncology Letters 32.4 (2026): 439.
Chicago
Mazzoni, C., Argnani, L., Di Benedetto, D., Bakken, S. M., Casadei, B., Pellegrini, C., De Marco, L., Machado, M., Broccoli, A., Zinzani, P. L., Serra, C."Accuracy of percutaneous ultrasound‑guided needle biopsy of abdominal lymph nodes for the diagnosis of malignant disease". Oncology Letters 32, no. 4 (2026): 439. https://doi.org/10.3892/ol.2026.15794
Copy and paste a formatted citation
x
Spandidos Publications style
Mazzoni C, Argnani L, Di Benedetto D, Bakken SM, Casadei B, Pellegrini C, De Marco L, Machado M, Broccoli A, Zinzani PL, Zinzani PL, et al: Accuracy of percutaneous ultrasound‑guided needle biopsy of abdominal lymph nodes for the diagnosis of malignant disease. Oncol Lett 32: 439, 2026.
APA
Mazzoni, C., Argnani, L., Di Benedetto, D., Bakken, S.M., Casadei, B., Pellegrini, C. ... Serra, C. (2026). Accuracy of percutaneous ultrasound‑guided needle biopsy of abdominal lymph nodes for the diagnosis of malignant disease. Oncology Letters, 32, 439. https://doi.org/10.3892/ol.2026.15794
MLA
Mazzoni, C., Argnani, L., Di Benedetto, D., Bakken, S. M., Casadei, B., Pellegrini, C., De Marco, L., Machado, M., Broccoli, A., Zinzani, P. L., Serra, C."Accuracy of percutaneous ultrasound‑guided needle biopsy of abdominal lymph nodes for the diagnosis of malignant disease". Oncology Letters 32.4 (2026): 439.
Chicago
Mazzoni, C., Argnani, L., Di Benedetto, D., Bakken, S. M., Casadei, B., Pellegrini, C., De Marco, L., Machado, M., Broccoli, A., Zinzani, P. L., Serra, C."Accuracy of percutaneous ultrasound‑guided needle biopsy of abdominal lymph nodes for the diagnosis of malignant disease". Oncology Letters 32, no. 4 (2026): 439. https://doi.org/10.3892/ol.2026.15794
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