|
1
|
Chang MS, Azin M and Demehri S: Cutaneous
squamous cell carcinoma: The frontier of cancer immunoprevention.
Annu Rev Pathol. 17:101–119. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Karia PS, Han J and Schmults CD: Cutaneous
squamous cell carcinoma: Estimated incidence of disease, nodal
metastasis, and deaths from disease in the United States, 2012. J
Am Acad Dermatol. 68:957–966. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Schmults CD, Karia PS, Carter JB, Han J
and Qureshi AA: Factors predictive of recurrence and death from
cutaneous squamous cell carcinoma: A 10-year, single-institution
cohort study. JAMA Dermatol. 149:541–547. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Hughes BGM, Munoz-Couselo E, Mortier L,
Bratland Å, Gutzmer R, Roshdy O, González Mendoza R, Schachter J,
Arance A, Grange F, et al: Pembrolizumab for locally advanced and
recurrent/metastatic cutaneous squamous cell carcinoma (KEYNOTE-629
study): An open-label, nonrandomized, multicenter, phase II trial.
Ann Oncol. 32:1276–1285. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Hiller A, Oxford M, Kulkarni P, Fornadley
J, Lo A, Sivik J, Drabick J and Vakharia K: Efficacy of cemiplimab
as adjuvant or neoadjuvant therapy in the treatment of cutaneous
squamous cell carcinoma. Ann Plast Surg. 92 (4S Suppl 2):S129–S131.
2024. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Hanna GJ, Ruiz ES, LeBoeuf NR, Thakuria M,
Schmults CD, Decaprio JA and Silk AW: Real-world outcomes treating
patients with advanced cutaneous squamous cell carcinoma with
immune checkpoint inhibitors (CPI). Br J Cancer. 123:1535–1542.
2020. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Galambus J and Tsai KY: Molecular and
immune targets in cutaneous squamous cell carcinoma. Mol Carcinog.
62:38–51. 2023. View
Article : Google Scholar : PubMed/NCBI
|
|
8
|
Di Nardo L, Pellegrini C, Di Stefani A,
Del Regno L, Sollena P, Piccerillo A, Longo C, Garbe C, Fargnoli MC
and Peris K: Molecular genetics of cutaneous squamous cell
carcinoma: Perspective for treatment strategies. J Eur Acad
Dermatol Venereol. 34:932–941. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Thai AA, Lim AM, Solomon BJ and Rischin D:
Biology and treatment advances in cutaneous squamous cell
carcinoma. Cancers (Basel). 13:56452021. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Pham JP, Rodrigues A, Goldinger SM, Sim HW
and Liu J: Epidermal growth factor receptor inhibitors in advanced
cutaneous squamous cell carcinoma: A systematic review and
meta-analysis. Exp Dermatol. 33:e149782024. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Colombo E, Gurizzan C, Ottini A, Caspani
F, Bergamini C, Locati LD, Marchiselli C, Alberti A, Lorini L,
Licitra LF, et al: The association of cemiplimab plus sonidegib for
synchronous cutaneous squamous cell carcinoma and basal cell
carcinoma of the head and neck: Two case reports. Front Oncol.
13:11111462023. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
London M and Gallo E: Epidermal growth
factor receptor (EGFR) involvement in epithelial-derived cancers
and its current antibody-based immunotherapies. Cell Biol Int.
44:1267–1282. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Cañueto J, Cardeñoso E, García JL,
Santos-Briz Á, Castellanos-Martín A, Fernández-López E, Blanco
Gómez A, Pérez-Losada J and Román-Curto C: Epidermal growth factor
receptor expression is associated with poor outcome in cutaneous
squamous cell carcinoma. Br J Dermatol. 176:1279–1287. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Sweeny L, Dean NR, Magnuson JS, Carroll
WR, Helman EE, Hyde SO, Desmond RL and Rosenthal EL: EGFR
expression in advanced head and neck cutaneous squamous cell
carcinoma. Head Neck. 34:681–686. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Yang B, Zhang H, Dong L, Wang J and Yu N:
Identification of PI3K/AKT/mTOR-related genes as diagnostic
biomarkers for cutaneous squamous cell carcinoma. Biochem Biophys
Rep. 45:1023552025.PubMed/NCBI
|
|
16
|
Chang M, Samlowski W and Meoz R:
Effectiveness and toxicity of cetuximab with concurrent RT in
locally advanced cutaneous squamous cell skin cancer: A case
series. Oncotarget. 14:709–718. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Riihilä P, Viiklepp K, Nissinen L,
Farshchian M, Kallajoki M, Kivisaari A, Meri S, Peltonen J,
Peltonen S and Kähäri VM: Tumour-cell-derived complement components
C1r and C1s promote growth of cutaneous squamous cell carcinoma. Br
J Dermatol. 182:658–670. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Zou DD, Sun YZ, Li XJ, Wu WJ, Xu D, He YT,
Qi J, Tu Y, Tang Y, Tu YH, et al: Single-cell sequencing highlights
heterogeneity and malignant progression in actinic keratosis and
cutaneous squamous cell carcinoma. Elife. 12:e852702023. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Ji AL, Rubin AJ, Thrane K, Jiang S,
Reynolds DL, Meyers RM, Guo MG, George BM, Mollbrink A,
Bergenstråhle J, et al: Multimodal analysis of composition and
spatial architecture in human squamous cell carcinoma. Cell.
182:497–514.e22. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Schütz S, Solé-Boldo L, Lucena-Porcel C,
Hoffmann J, Brobeil A, Lonsdorf AS, Rodríguez-Paredes M and Lyko F:
Functionally distinct cancer-associated fibroblast subpopulations
establish a tumor promoting environment in squamous cell carcinoma.
Nat Commun. 14:54132023. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Li X, Zhao S, Bian X, Zhang L, Lu L, Pei
S, Dong L, Shi W, Huang L, Zhang X, et al: Signatures of EMT,
immunosuppression, and inflammation in primary and recurrent human
cutaneous squamous cell carcinoma at single-cell resolution.
Theranostics. 12:7532–7549. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Barrett T and Edgar R: Mining microarray
data at NCBI's gene expression omnibus (GEO)*. Methods Mol Biol.
338:175–190. 2006.PubMed/NCBI
|
|
23
|
Tian Q, Wang M, Mubeen F, Sundas A, Naz R,
Hu X and Chen X: CDKN2A and matrix metalloproteinases: Key
regulators of cellular senescence in squamous cell carcinoma. Am J
Transl Res. 17:4573–4589. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
O'Donnell BL, Johnston D, Bhatt A, Kardan
Z, Stefan D, Bysice A, Sayedyahossein S, Dagnino L, Cecchini M,
Loganathan SK, et al: Pannexin 1 and pannexin 3 differentially
regulate the cancer cell properties of cutaneous squamous cell
carcinoma. J Physiol. 603:4409–4432. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Stelzer G, Rosen N, Plaschkes I, Zimmerman
S, Twik M, Fishilevich S, Stein TI, Nudel R, Lieder I, Mazor Y, et
al: The GeneCards suite: From gene data mining to disease genome
sequence analyses. Curr Protoc Bioinformatics. 54:1.30.1–1.30.33.
2016. View
Article : Google Scholar : PubMed/NCBI
|
|
26
|
Sherman BT, Hao M, Qiu J, Jiao X, Baseler
MW, Lane HC, Imamichi T and Chang W: DAVID: A web server for
functional enrichment analysis and functional annotation of gene
lists (2021 update). Nucleic Acids Res. 50((W1)): W216–W221. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Kanehisa M: The KEGG database. Novartis
Found Symp. 247:91–103. 119–128. 244–252. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Ashburner M, Ball CA, Blake JA, Botstein
D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT,
et al: Gene ontology: Tool for the unification of biology. The gene
ontology consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Szklarczyk D, Gable AL, Nastou KC, Lyon D,
Kirsch R, Pyysalo S, Doncheva NT, Legeay M, Fang T, Bork P, et al:
The STRING database in 2021: Customizable protein-protein networks,
and functional characterization of user-uploaded gene/measurement
sets. Nucleic Acids Res. 49(D1): D605–D612. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Smoot ME, Ono K, Ruscheinski J, Wang PL
and Ideker T: Cytoscape 2.8: New features for data integration and
network visualization. Bioinformatics. 27:431–432. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Saito R, Smoot ME, Ono K, Ruscheinski J,
Wang PL, Lotia S, Pico AR, Bader GD and Ideker T: A travel guide to
Cytoscape plugins. Nat Methods. 9:1069–1076. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Chin CH, Chen SH, Wu HH L, Ho CW, Ko MT
and Lin CY: cytoHubba: Identifying hub objects and sub-networks
from complex interactome. BMC Syst Biol. 8 (Suppl 4):S112014.
View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Karumuri R, Shah D and Arnouk H: Cornulin
as a potential novel biomarker for cutaneous squamous cell
carcinoma. Cureus. 14:e316942022.PubMed/NCBI
|
|
34
|
da Silva CN, Grassi TF, Miot HA and
Espósito ACC: Expression of the aryl hydrocarbon receptor (AhR) in
facial melasma skin compared to healthy perilesional skin. An Bras
Dermatol. 100:5011812025. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Catalano M, Nozzoli F, De Logu F, Nassini
R and Roviello G: Management approaches for high-risk cutaneous
squamous cell carcinoma with perineural invasion: An updated
review. Curr Treat Options Oncol. 25:1184–1192. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Winge MCG, Kellman LN, Guo K, Tang JY,
Swetter SM, Aasi SZ, Sarin KY, Chang ALS and Khavari PA: Advances
in cutaneous squamous cell carcinoma. Nat Rev Cancer. 23:430–449.
2023. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Venables ZC, Autier P, Nijsten T, Wong KF,
Langan SM, Rous B, Broggio J, Harwood C, Henson K, Proby CM, et al:
Nationwide incidence of metastatic cutaneous squamous cell
carcinoma in England. JAMA Dermatol. 155:298–306. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Tokez S, Wakkee M, Kan W, Venables ZC,
Mooyaart AL, Louwman M, Nijsten T and Hollestein LM: Cumulative
incidence and disease-specific survival of metastatic cutaneous
squamous cell carcinoma: A nationwide cancer registry study. J Am
Acad Dermatol. 86:331–338. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Corchado-Cobos R, García-Sancha N,
González-Sarmiento R, Pérez-Losada J and Cañueto J: Cutaneous
squamous cell carcinoma: from biology to therapy. Int J Mol Sci.
21:29562020. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Bailey P, Ridgway RA, Cammareri P,
Treanor-Taylor M, Bailey UM, Schoenherr C, Bone M, Schreyer D,
Purdie K, Thomson J, et al: Driver gene combinations dictate
cutaneous squamous cell carcinoma disease continuum progression.
Nat Commun. 14:52112023. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Kim YS, Jung SH, Park YM, Park GS, Kim HS,
Maeng LS and Chung YJ: Targeted deep sequencing reveals genomic
alterations of actinic keratosis/cutaneous squamous cell carcinoma
in situ and cutaneous squamous cell carcinoma. Exp Dermatol.
32:447–456. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Ke Y and Wang XJ: TGFβ signaling in
photoaging and UV-induced skin cancer. J Invest Dermatol.
141((4S)): S1104–S1110. 2021. View Article : Google Scholar
|
|
43
|
Ascierto PA and Schadendorf D: Update in
the treatment of non-melanoma skin cancers: The use of PD-1
inhibitors in basal cell carcinoma and cutaneous squamous-cell
carcinoma. J Immunother Cancer. 10:e0050822022. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Anderson-Crannage M, Ascensión AM,
Ibanez-Solé O, Zhu H, Schaefer E, Ottomanelli D, Hochberg B, Pan J,
Luo W, Tian M, et al: Inflammation-mediated fibroblast activation
and immune dysregulation in collagen VII-deficient skin. Front
Immunol. 14:12115052023. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Riihilä P, Nissinen L and Kähäri VM:
Matrix metalloproteinases in keratinocyte carcinomas. Exp Dermatol.
30:50–61. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Ahmady S, Jansen MHE, Nelemans PJ, Kessels
JPHM, Arits AHMM, de Rooij MJM, Essers BAB, Quaedvlieg PJF,
Kelleners-Smeets NWJ and Mosterd K: Risk of invasive cutaneous
squamous cell carcinoma after different treatments for actinic
keratosis: A secondary analysis of a randomized clinical trial.
JAMA Dermatol. 158:634–640. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Hareendran S, Albraidy B, Yang X, Liu A,
Breggia A, Chen CC and Loh YP: Exosomal carboxypeptidase E (CPE)
and CPE-shRNA-loaded exosomes regulate metastatic phenotype of
tumor cells. Int J Mol Sci. 23:31132022. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Fuchs A and Marmur E: The kinetics of skin
cancer: Progression of actinic keratosis to squamous cell
carcinoma. Dermatol Surg. 33:1099–1101. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Thind AS, Ashford B, Strbenac D, Mitchell
J, Lee J, Mueller SA, Minaei E, Perry JR, Ch'ng S, Iyer NG, et al:
Whole genome analysis reveals the genomic complexity in metastatic
cutaneous squamous cell carcinoma. Front Oncol. 12:9191182022.
View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Lu H, Peng Z, Zheng Z, Li C, Wang Y, Liang
L, Chen Y and Zeng K: Blocking the ATR-SerRS-VEGFA pathway targets
angiogenesis for UV-induced cutaneous squamous cell carcinoma. Mol
Carcinogs. 63:1160–1173. 2024. View Article : Google Scholar
|
|
51
|
Ding Y, Yi J, Wang J and Sun Z:
Interleukin-1 receptor antagonist: A promising cytokine against
human squamous cell carcinomas. Heliyon. 9:e149602023. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Powers JM, Murphy G, Ralph N, O'Gorman SM
and Murphy JEJ: Polypharmacy and sun exposure: Implications for
mitochondrial DNA deletions in skin. J Photochem Photobiol B.
173:397–403. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Khalaf K, Hana D, Chou JT, Singh C,
Mackiewicz A and Kaczmarek M: Aspects of the tumor microenvironment
involved in immune resistance and drug resistance. Front Immunol.
12:6563642021. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Simon T and Salhia B: Cancer-associated
fibroblast subpopulations with diverse and dynamic roles in the
tumor microenvironment. Mol Cancer Res. 20:183–192. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Mao X, Xu J, Wang W, Liang C, Hua J, Liu
J, Zhang B, Meng Q, Yu X and Shi S: Crosstalk between
cancer-associated fibroblasts and immune cells in the tumor
microenvironment: New findings and future perspectives. Mol Cancer.
20:1312021. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Chen J, Dang Y, Feng W, Qiao C, Liu D,
Zhang T, Wang Y, Tian D, Fan D, Nie Y, et al: SOX18 promotes
gastric cancer metastasis through transactivating MCAM and CCL7.
Oncogene. 39:5536–5552. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
An Y, Wei N, Cheng X, Li Y, Liu H, Wang J,
Xu Z, Sun Z and Zhang X: MCAM abnormal expression and clinical
outcome associations are highly cancer dependent as revealed
through pan-cancer analysis. Brief Bioinform. 21:709–718. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Pang Y, Maxwell E, Sindrewicz-Goral P,
Shapanis A, Li S, Morgan M and Yu LG: Galectin-3 is a natural
binding ligand of MCAM (CD146, MUC18) in melanoma cells and their
interaction promotes melanoma progression. Biomolecules.
12:14512022. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Kobayashi H, Gieniec KA, Lannagan TRM,
Wang T, Asai N, Mizutani Y, Iida T, Ando R, Thomas EM, Sakai A, et
al: The origin and contribution of cancer-associated fibroblasts in
colorectal carcinogenesis. Gastroenterology. 162:890–906. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Yang W, Zhang S, Li T, Zhou Z and Pan J:
Single-cell analysis reveals that cancer-associated fibroblasts
stimulate oral squamous cell carcinoma invasion via the TGF-β/Smad
pathway. Acta Biochim Biophys Sin (Shanghai). 55:262–273. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Jain S, Rick JW, Joshi RS, Beniwal A,
Spatz J, Gill S, Chang AC, Choudhary N, Nguyen AT, Sudhir S, et al:
Single-cell RNA sequencing and spatial transcriptomics reveal
cancer-associated fibroblasts in glioblastoma with protumoral
effects. J Clin Invest. 133:e1470872023. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Wei X, Lou H, Zhou D, Jia Y, Li H, Huang
Q, Ma J, Yang Z, Sun C, Meng Y, et al: TAGLN mediated
stiffness-regulated ovarian cancer progression via RhoA/ROCK
pathway. J Exp Clin Cancer Res. 40:2922021. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Sarubo M, Mouri Y, Moromizato A, Yamada A,
Jin S, Shao W, Hagita H, Miyoshi K and Kudo Y: Involvement of
TGFBI-TAGLN axis in cancer stem cell property of head and neck
squamous cell carcinoma. Sci Rep. 14:67672024. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Li H, Song C, Zhang Y, Liu G, Mi H, Li Y,
Chen Z, Ma X, Zhang P, Cheng L, et al: Transgelin promotes
glioblastoma stem cell hypoxic responses and maintenance through
p53 acetylation. Adv Sci (Weinh). 11:e23056202024. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Ganier C, Mazin P, Herrera-Oropeza G,
Du-Harpur X, Blakeley M, Gabriel J, Predeus AV, Cakir B, Prete M,
Harun N, et al: Multiscale spatial mapping of cell populations
across anatomical sites in healthy human skin and basal cell
carcinoma. Proc Natl Acad Sci USA. 121:e23133261202024. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Wu X, Lu W, Zhang W, Zhang D, Mei H, Zhang
M, Cui Y and Zhuo Z: Integrated analysis of single-cell RNA-seq and
bulk RNA-seq unravels the heterogeneity of cancer-associated
fibroblasts in TNBC. Aging (Albany NY). 15:12674–12697. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Primac I, Maquoi E, Blacher S, Heljasvaara
R, Van Deun J, Smeland HY, Canale A, Louis T, Stuhr L, Sounni NE,
et al: Stromal integrin α11 regulates PDGFR-β signaling and
promotes breast cancer progression. J Clin Invest. 129:4609–4628.
2019. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Wu SZ, Roden DL, Wang C, Holliday H,
Harvey K, Cazet AS, Murphy KJ, Pereira B, Al-Eryani G, Bartonicek
N, et al: Stromal cell diversity associated with immune evasion in
human triple-negative breast cancer. EMBO J. 39:e1040632020.
View Article : Google Scholar : PubMed/NCBI
|