Renal carcinoid tumor: An immunohistochemical and molecular genetic study of four cases

  • Authors:
    • Naoto Kuroda
    • Isabel Alvarado-Cabrero
    • Radek Sima
    • Ondrej Hes
    • Michal Michal
    • Hidefumi Kinoshita
    • Tadashi Matsuda
    • Chisato Ohe
    • Noriko Sakaida
    • Yoshiko Uemura
    • Gang-Hong Lee
  • View Affiliations

  • Published online on: January 1, 2010     https://doi.org/10.3892/ol_00000015
  • Pages: 87-90
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Abstract

Few genetic studies of renal carcinoid tumor have been conducted thus far. We performed immunohistochemical and genetic examinations on four renal carcinoid tumors. Histologically, the tumors consisted of neoplastic cells with round to oval nuclei. Various growth patterns such as tightly packed cords and trabeculae, ribbon-like, trabecular, sheet-like or solid growth were observed. Nuclear chromatin showed a coarse and granular pattern. Immunohistochemically, tumors were positive for chromogranin A and synaptophysin. In the fluorescence in situ hybridization study, three of four tumors revealed monosomy of chromosome 3 (D3Z1), but one tumor showed monosomy of chromosome 13 (D13S319/13q34). Using PCR amplification and fragment analysis of three microsatellite markers (D3S1300, D3S666 and D3S1768) of chromosome arm 3p, one tumor showed loss of heterozygosity at D3S1300 and D3S1768, one tumor was not informative and the analysis of two tumors failed due to low DNA quality. In three cases, the VHL gene status was tested. Two tumors showed wild-type, but the analysis of one tumor failed to provide adequate results. In conclusion, we suggest that the abnormality of chromosome 3 is involved in the pathogenesis of renal carcinoid tumor.
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January-February 2010
Volume 1 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Kuroda N, Alvarado-Cabrero I, Sima R, Hes O, Michal M, Kinoshita H, Matsuda T, Ohe C, Sakaida N, Uemura Y, Uemura Y, et al: Renal carcinoid tumor: An immunohistochemical and molecular genetic study of four cases . Oncol Lett 1: 87-90, 2010.
APA
Kuroda, N., Alvarado-Cabrero, I., Sima, R., Hes, O., Michal, M., Kinoshita, H. ... Lee, G. (2010). Renal carcinoid tumor: An immunohistochemical and molecular genetic study of four cases . Oncology Letters, 1, 87-90. https://doi.org/10.3892/ol_00000015
MLA
Kuroda, N., Alvarado-Cabrero, I., Sima, R., Hes, O., Michal, M., Kinoshita, H., Matsuda, T., Ohe, C., Sakaida, N., Uemura, Y., Lee, G."Renal carcinoid tumor: An immunohistochemical and molecular genetic study of four cases ". Oncology Letters 1.1 (2010): 87-90.
Chicago
Kuroda, N., Alvarado-Cabrero, I., Sima, R., Hes, O., Michal, M., Kinoshita, H., Matsuda, T., Ohe, C., Sakaida, N., Uemura, Y., Lee, G."Renal carcinoid tumor: An immunohistochemical and molecular genetic study of four cases ". Oncology Letters 1, no. 1 (2010): 87-90. https://doi.org/10.3892/ol_00000015