Renal carcinoid tumor: An immunohistochemical and molecular genetic study of four cases

Kuroda,Naoto; Alvarado-Cabrero,Isabel; Sima,Radek; Hes,Ondrej; Michal,Michal; Kinoshita,Hidefumi; Matsuda,Tadashi; Ohe,Chisato; Sakaida,Noriko; Uemura,Yoshiko; Lee,Gang-Hong

doi:10.3892/ol_00000015

January-February 2010 Volume 1 Issue 1

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January-February 2010 Volume 1 Issue 1

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Article

Renal carcinoid tumor: An immunohistochemical and molecular genetic study of four cases

Authors:
- Naoto Kuroda
- Isabel Alvarado-Cabrero
- Radek Sima
- Ondrej Hes
- Michal Michal
- Hidefumi Kinoshita
- Tadashi Matsuda
- Chisato Ohe
- Noriko Sakaida
- Yoshiko Uemura
- Gang-Hong Lee
View Affiliations / Copyright

Affiliations: Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi 780-8562, Japan. kurochankochi@yahoo.co.jp
Pages: 87-90
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Published online on: January 1, 2010

https://doi.org/10.3892/ol_00000015
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Abstract

Few genetic studies of renal carcinoid tumor have been conducted thus far. We performed immunohistochemical and genetic examinations on four renal carcinoid tumors. Histologically, the tumors consisted of neoplastic cells with round to oval nuclei. Various growth patterns such as tightly packed cords and trabeculae, ribbon-like, trabecular, sheet-like or solid growth were observed. Nuclear chromatin showed a coarse and granular pattern. Immunohistochemically, tumors were positive for chromogranin A and synaptophysin. In the fluorescence in situ hybridization study, three of four tumors revealed monosomy of chromosome 3 (D3Z1), but one tumor showed monosomy of chromosome 13 (D13S319/13q34). Using PCR amplification and fragment analysis of three microsatellite markers (D3S1300, D3S666 and D3S1768) of chromosome arm 3p, one tumor showed loss of heterozygosity at D3S1300 and D3S1768, one tumor was not informative and the analysis of two tumors failed due to low DNA quality. In three cases, the VHL gene status was tested. Two tumors showed wild-type, but the analysis of one tumor failed to provide adequate results. In conclusion, we suggest that the abnormality of chromosome 3 is involved in the pathogenesis of renal carcinoid tumor.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Renal carcinoid tumor: An immunohistochemical and molecular genetic study of four cases

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