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Article

Phase I trial of oxaliplatin plus S-1 chemotherapy in patients with metastatic colorectal cancer

  • Authors:
    • Manabu Emi
    • Yoshiyuki Yamaguchi
    • Jun Hihara
    • Katsuji Hironaka
    • Morihito Okada
  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan. moaista@wish.ocn.ne.jp
  • Pages: 95-98
    |
    Published online on: January 1, 2010
       https://doi.org/10.3892/ol_00000017
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Abstract

Advanced colorectal cancer can be effectively treated with S-1, as well as with a combination of oxaliplatin, 5-fluorouracil (5FU) and leucovorin (LV). However, S-1 together with oxaliplatin may provide a more convenient alternative to 5FU/LV. To evaluate the performance of S-1 combined with oxaliplatin for patients with colorectal cancer, we conducted a Phase I clinical trial in an outpatient setting. We administered S-1 to 15 patients with advanced colorectal adenocarcinoma for two weeks followed by one week of rest. Oxaliplatin was also administered on day 1 of the S-1 cycle. The dose of oxaliplatin was increased from 40 to 85 mg/m2 to define the maximum tolerated dose and recommended dose in preparation for a Phase II trial. We administered 102 courses of treatment to 15 patients. Grade 3 thrombocytopenia developed in only 1 patient at a dose of 85 mg/m2 of oxaliplatin plus oral S-1. No other grade 3-4 toxicities developed. No dose-limiting toxicity developed at level 4 of our regimen (oxaliplatin 85 mg/m2), and the recommended dose for a Phase II trial was 85 mg/m2 of oxaliplatin in an outpatient setting.
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Copy and paste a formatted citation
Spandidos Publications style
Emi M, Yamaguchi Y, Hihara J, Hironaka K and Okada M: Phase I trial of oxaliplatin plus S-1 chemotherapy in patients with metastatic colorectal cancer . Oncol Lett 1: 95-98, 2010.
APA
Emi, M., Yamaguchi, Y., Hihara, J., Hironaka, K., & Okada, M. (2010). Phase I trial of oxaliplatin plus S-1 chemotherapy in patients with metastatic colorectal cancer . Oncology Letters, 1, 95-98. https://doi.org/10.3892/ol_00000017
MLA
Emi, M., Yamaguchi, Y., Hihara, J., Hironaka, K., Okada, M."Phase I trial of oxaliplatin plus S-1 chemotherapy in patients with metastatic colorectal cancer ". Oncology Letters 1.1 (2010): 95-98.
Chicago
Emi, M., Yamaguchi, Y., Hihara, J., Hironaka, K., Okada, M."Phase I trial of oxaliplatin plus S-1 chemotherapy in patients with metastatic colorectal cancer ". Oncology Letters 1, no. 1 (2010): 95-98. https://doi.org/10.3892/ol_00000017
Copy and paste a formatted citation
x
Spandidos Publications style
Emi M, Yamaguchi Y, Hihara J, Hironaka K and Okada M: Phase I trial of oxaliplatin plus S-1 chemotherapy in patients with metastatic colorectal cancer . Oncol Lett 1: 95-98, 2010.
APA
Emi, M., Yamaguchi, Y., Hihara, J., Hironaka, K., & Okada, M. (2010). Phase I trial of oxaliplatin plus S-1 chemotherapy in patients with metastatic colorectal cancer . Oncology Letters, 1, 95-98. https://doi.org/10.3892/ol_00000017
MLA
Emi, M., Yamaguchi, Y., Hihara, J., Hironaka, K., Okada, M."Phase I trial of oxaliplatin plus S-1 chemotherapy in patients with metastatic colorectal cancer ". Oncology Letters 1.1 (2010): 95-98.
Chicago
Emi, M., Yamaguchi, Y., Hihara, J., Hironaka, K., Okada, M."Phase I trial of oxaliplatin plus S-1 chemotherapy in patients with metastatic colorectal cancer ". Oncology Letters 1, no. 1 (2010): 95-98. https://doi.org/10.3892/ol_00000017
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