Arylthioindoles: Promising compounds against cancer cell proliferation

Giansanti,Vincenzo; Piscitelli,Francesco; Camboni,Tania; Prosperi,Ennio; La Regina,Giuseppe; Parks,Michele; Silvestri,Romano; Scovassi,Anna I.

doi:10.3892/ol_00000020

January-February 2010 Volume 1 Issue 1

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January-February 2010 Volume 1 Issue 1

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Article

Arylthioindoles: Promising compounds against cancer cell proliferation

Authors:
- Vincenzo Giansanti
- Francesco Piscitelli
- Tania Camboni
- Ennio Prosperi
- Giuseppe La Regina
- Michele Parks
- Romano Silvestri
- Anna I. Scovassi
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Affiliations: Istituto di Genetica Molecolare CNR, 27100 Pavia, Italy
Pages: 109-112
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Published online on: January 1, 2010

https://doi.org/10.3892/ol_00000020
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Abstract

Drugs that are able to modulate the microtubule dynamics either by inhibiting tubulin polymerization or by blocking microtubule disassembly are of great interest in anti-cancer therapy; a number of them are currently applied in clinical development. Tubulin polymerization inhibitors, including arylthioindoles, are characterized by the presence of an indole nucleus and have been obtained from natural sources or prepared by semi-synthesis. We characterized the effect of 5-bromo-3-[(3,4,5-trimetoxyphenyl)thio]-1H-indole (RS 2518) on the metabolism of human cell lines derived from solid tumors. We found that this new compound impairs cell adhesion, arrests the cells in the G2/M cell cycle phase and inhibits cell proliferation, thus leading to apoptosis. The described effects of RS 2518 on cancer cells have led to its selection as a lead compound for further studies. Some analogues have been developed and tested on a panel of cancer cell lines.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Arylthioindoles: Promising compounds against cancer cell proliferation

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Abstract

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