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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Postoperative infections are associated with adverse outcome after resection with curative intent for colorectal cancer

  • Authors:
    • Hironori Tsujimoto
    • Hideki Ueno
    • Yojiro Hashiguchi
    • Satoshi Ono
    • Takashi Ichikura
    • Kazuo Hase
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, National Defense Medical College, Tokorozawa 359-8513, Japan. tsujihi@ndmc.ac.jp
  • Pages: 119-125
    |
    Published online on: January 1, 2010
       https://doi.org/10.3892/ol_00000022
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Abstract

This study focused on the impact of post-operative infection on patient outcome after resection with curative intent for colorectal cancer. Postoperative surgical and medical complications have been implicated as a negative predictor of long-term outcome in various malignancies. We studied a population of 1083 patients who underwent resection with curative intent for colorectal cancer. These patients were divided into 2 groups based on the occurrence (65 patients, 6%) or absence (1018 patients, 94%) of postoperative complications due to infection. We investigated the demographic and clinicopathological features of each patient with and without postoperative infectious complications, as well as the impact of postoperative infection on long-term survival. Results showed that patients with postoperative infectious complications had diabetes mellitus more frequently and also had urgent surgery compared to those without infectious complications. In addition, patients with postoperative infectious complications had a significantly more unfavorable outcome compared with those without postoperative infection in cancer-specific, but not overall survival. Multivariate analysis demonstrated that age, rectal cancer and tumor stage correlated with overall survival, but not postoperative infectious complications. However, postoperative infections, as well as gender, were associated with the length of time until the patient succumbed from the recurrence of colorectal cancer after resection for curative intent. Thus, postoperative infectious complications are predictors of adverse clinical outcome in patients with colorectal cancer. However, further immunological study is necessary to confirm the biological significance of these findings.
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Copy and paste a formatted citation
Spandidos Publications style
Tsujimoto H, Ueno H, Hashiguchi Y, Ono S, Ichikura T and Hase K: Postoperative infections are associated with adverse outcome after resection with curative intent for colorectal cancer . Oncol Lett 1: 119-125, 2010.
APA
Tsujimoto, H., Ueno, H., Hashiguchi, Y., Ono, S., Ichikura, T., & Hase, K. (2010). Postoperative infections are associated with adverse outcome after resection with curative intent for colorectal cancer . Oncology Letters, 1, 119-125. https://doi.org/10.3892/ol_00000022
MLA
Tsujimoto, H., Ueno, H., Hashiguchi, Y., Ono, S., Ichikura, T., Hase, K."Postoperative infections are associated with adverse outcome after resection with curative intent for colorectal cancer ". Oncology Letters 1.1 (2010): 119-125.
Chicago
Tsujimoto, H., Ueno, H., Hashiguchi, Y., Ono, S., Ichikura, T., Hase, K."Postoperative infections are associated with adverse outcome after resection with curative intent for colorectal cancer ". Oncology Letters 1, no. 1 (2010): 119-125. https://doi.org/10.3892/ol_00000022
Copy and paste a formatted citation
x
Spandidos Publications style
Tsujimoto H, Ueno H, Hashiguchi Y, Ono S, Ichikura T and Hase K: Postoperative infections are associated with adverse outcome after resection with curative intent for colorectal cancer . Oncol Lett 1: 119-125, 2010.
APA
Tsujimoto, H., Ueno, H., Hashiguchi, Y., Ono, S., Ichikura, T., & Hase, K. (2010). Postoperative infections are associated with adverse outcome after resection with curative intent for colorectal cancer . Oncology Letters, 1, 119-125. https://doi.org/10.3892/ol_00000022
MLA
Tsujimoto, H., Ueno, H., Hashiguchi, Y., Ono, S., Ichikura, T., Hase, K."Postoperative infections are associated with adverse outcome after resection with curative intent for colorectal cancer ". Oncology Letters 1.1 (2010): 119-125.
Chicago
Tsujimoto, H., Ueno, H., Hashiguchi, Y., Ono, S., Ichikura, T., Hase, K."Postoperative infections are associated with adverse outcome after resection with curative intent for colorectal cancer ". Oncology Letters 1, no. 1 (2010): 119-125. https://doi.org/10.3892/ol_00000022
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