Chemoradiotherapy with 5-fluorouracil/leucovorin, surgery and adjuvant chemotherapy for locally advanced rectal cancer

  • Authors:
    • M. Baur
    • M. Horvath
    • S. Stättner
    • A. Schratter-Sehn
    • B. Horvath
    • F. Sellner
    • M. Hudec
    • M. Klimpfinger
    • C. Dittrich
    • J. Karner
  • View Affiliations

  • Published online on: January 1, 2010     https://doi.org/10.3892/ol_00000035
  • Pages: 189-194
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Abstract

The aim of this study was to demonstrate a pathologic complete response (pCR) rate of at least 10% with an acceptable toxicity achieved by preoperative chemoradiotherapy with 5-fluorouracil (5-FU)/leucovorin in patients with locally advanced rectal cancer. Patients were treated by radiotherapy targeting 50 Gy and 5-FU/leucovorin intravenously during the 1st, 4th and 7th week after start of radiotherapy followed by surgery and adjuvant chemotherapy. In 71 evaluable patients, the pCR rate was 14.1% (95% CI, 6.0-22.2); the local relapse rate, 6.1%; the 5-year disease-free survival, 54% and the overall 5-year survival, 68%. The most severe adverse events were neutropenia (17%), diarrhoea (17%), infection (8%) and fatal cardiovascular function (1%). This therapy yielded a high rate of pCR, a low rate of local relapse and a long disease-free and overall survival. To increase its feasibility, radiation dose reduction to 45 Gy and administration of only two preoperative cycles of chemotherapy is recommended.
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January-February 2010
Volume 1 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Baur M, Horvath M, Stättner S, Schratter-Sehn A, Horvath B, Sellner F, Hudec M, Klimpfinger M, Dittrich C, Karner J, Karner J, et al: Chemoradiotherapy with 5-fluorouracil/leucovorin, surgery and adjuvant chemotherapy for locally advanced rectal cancer . Oncol Lett 1: 189-194, 2010
APA
Baur, M., Horvath, M., Stättner, S., Schratter-Sehn, A., Horvath, B., Sellner, F. ... Karner, J. (2010). Chemoradiotherapy with 5-fluorouracil/leucovorin, surgery and adjuvant chemotherapy for locally advanced rectal cancer . Oncology Letters, 1, 189-194. https://doi.org/10.3892/ol_00000035
MLA
Baur, M., Horvath, M., Stättner, S., Schratter-Sehn, A., Horvath, B., Sellner, F., Hudec, M., Klimpfinger, M., Dittrich, C., Karner, J."Chemoradiotherapy with 5-fluorouracil/leucovorin, surgery and adjuvant chemotherapy for locally advanced rectal cancer ". Oncology Letters 1.1 (2010): 189-194.
Chicago
Baur, M., Horvath, M., Stättner, S., Schratter-Sehn, A., Horvath, B., Sellner, F., Hudec, M., Klimpfinger, M., Dittrich, C., Karner, J."Chemoradiotherapy with 5-fluorouracil/leucovorin, surgery and adjuvant chemotherapy for locally advanced rectal cancer ". Oncology Letters 1, no. 1 (2010): 189-194. https://doi.org/10.3892/ol_00000035