IGF-IR and its inhibitors in gastrointestinal carcinomas (Review)

  • Authors:
    • Xiao H. Bao
    • Yoshio Naomoto
    • Hui F. Hao
    • Nobuyuki Watanabe
    • Kazufumi Sakurama
    • Kazuhiro Noma
    • Takayuki Motoki
    • Yasuko Tomono
    • Takuya Fukazawa
    • Yasuhiro Shirakawa
    • Tomoki Yamatsuji
    • Junji Matsuoka
    • Munenori Takaoka
  • View Affiliations

  • Published online on: January 1, 2010     https://doi.org/10.3892/ol_00000036
  • Pages: 195-201
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Abstract

The type I insulin-like growth factor receptor (IGF-IR) and its associated signaling system play a significant role in tumorigenesis, tumor survival and progression, and cancer therapeutic resistance, and thus has provoked great interest as a promising target for cancer treatment. In this report we present the role of IGF-IR in gastrointestinal carcinomas whose pathology has been identified as tightly correlated with an abnormal expression and activation of IGF-IR. Reported data from experimental studies suggest the feasibility of targeted IGF-IR therapy in gastrointestinal carcinomas. Many types of inhibitors against IGF-IR have been developed. Inhibitors with anti-IGF-IR monoclonal antibodies and tyrosine kinase inhibitors currently undergoing preclinical and clinical evolution are also reviewed.
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January-February 2010
Volume 1 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Bao XH, Naomoto Y, Hao HF, Watanabe N, Sakurama K, Noma K, Motoki T, Tomono Y, Fukazawa T, Shirakawa Y, Shirakawa Y, et al: IGF-IR and its inhibitors in gastrointestinal carcinomas (Review) . Oncol Lett 1: 195-201, 2010
APA
Bao, X.H., Naomoto, Y., Hao, H.F., Watanabe, N., Sakurama, K., Noma, K. ... Takaoka, M. (2010). IGF-IR and its inhibitors in gastrointestinal carcinomas (Review) . Oncology Letters, 1, 195-201. https://doi.org/10.3892/ol_00000036
MLA
Bao, X. H., Naomoto, Y., Hao, H. F., Watanabe, N., Sakurama, K., Noma, K., Motoki, T., Tomono, Y., Fukazawa, T., Shirakawa, Y., Yamatsuji, T., Matsuoka, J., Takaoka, M."IGF-IR and its inhibitors in gastrointestinal carcinomas (Review) ". Oncology Letters 1.1 (2010): 195-201.
Chicago
Bao, X. H., Naomoto, Y., Hao, H. F., Watanabe, N., Sakurama, K., Noma, K., Motoki, T., Tomono, Y., Fukazawa, T., Shirakawa, Y., Yamatsuji, T., Matsuoka, J., Takaoka, M."IGF-IR and its inhibitors in gastrointestinal carcinomas (Review) ". Oncology Letters 1, no. 1 (2010): 195-201. https://doi.org/10.3892/ol_00000036