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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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January-February 2010 Volume 1 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Prognostic value of tumour endothelial markers in patients with endometrial cancer

  • Authors:
    • Nick A. Bersinger
    • Brigitte Schneider
    • Stephan A. Vorburger
    • Silke Johann
    • Daniel Candinas
    • Michael D. Mueller
  • View Affiliations / Copyright

    Affiliations: Inselspital, DKF, Berne CH-3010, Switzerland. nick.bersinger@dkf.unibe.ch
  • Pages: 203-207
    |
    Published online on: January 1, 2010
       https://doi.org/10.3892/ol_00000037
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Abstract

Endometrial cancer is one of the more frequent and most lethal gynaecological cancer types. Since it occurs more frequently in elderly and overweight patients, a pre-operative staging method would be beneficial. The growth of solid neoplasms is always accompanied by neovascularisation. Tumour endothelial markers (TEMs) are a group of recently described endothelial cell surface markers that appear to be specific to neoplastic tissue. This study aimed to investigate the potential usefulness of TEM assessment in the endometrium by comparing the transcriptional expression of TEMs in the normal endometrium with endometroid adenocarcinoma tissue. Tissues were lysed and the RNA was extracted, assessed and reverse transcribed in one batch. Real-time quantitative PCR was performed for TEM-1, -2, -6, -7, -7r and -8. GAPDH, β-actin and ribosomal protein L13A (RPL13A) were used as control genes. TEM-8 showed the highest expression level in all of the groups. TEM-1 showed higher expression levels in the normal endometrium than in the tumour tissues. For the remaining TEMs, we found a higher expression in the cancer samples than in the normal endometria. Statistical significance of this difference was achieved for TEM-1, -2 and-7. No clear correlation was noted between the tumour stage and the level of TEM-1, -6 and -8 expression. Apart from TEM-6, the highest expression in FIGO I cancer stages was noted in the remaining TEMs. Our results showed that for most of these tumour endothelial markers, gene expression was slightly higher in the endometrial carcinoma tissue samples than in the endometrium of normal cycling women. However, with the possible exception of TEM-8 and -6, absolute expression levels were generally low, indicating that most TEMs may only be specifically expressed in a restricted number of cancer types (e.g., colorectal). Therefore, TEMs may not be useful in the context of endometrial cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Bersinger NA, Schneider B, Vorburger SA, Johann S, Candinas D and Mueller MD: Prognostic value of tumour endothelial markers in patients with endometrial cancer . Oncol Lett 1: 203-207, 2010.
APA
Bersinger, N.A., Schneider, B., Vorburger, S.A., Johann, S., Candinas, D., & Mueller, M.D. (2010). Prognostic value of tumour endothelial markers in patients with endometrial cancer . Oncology Letters, 1, 203-207. https://doi.org/10.3892/ol_00000037
MLA
Bersinger, N. A., Schneider, B., Vorburger, S. A., Johann, S., Candinas, D., Mueller, M. D."Prognostic value of tumour endothelial markers in patients with endometrial cancer ". Oncology Letters 1.1 (2010): 203-207.
Chicago
Bersinger, N. A., Schneider, B., Vorburger, S. A., Johann, S., Candinas, D., Mueller, M. D."Prognostic value of tumour endothelial markers in patients with endometrial cancer ". Oncology Letters 1, no. 1 (2010): 203-207. https://doi.org/10.3892/ol_00000037
Copy and paste a formatted citation
x
Spandidos Publications style
Bersinger NA, Schneider B, Vorburger SA, Johann S, Candinas D and Mueller MD: Prognostic value of tumour endothelial markers in patients with endometrial cancer . Oncol Lett 1: 203-207, 2010.
APA
Bersinger, N.A., Schneider, B., Vorburger, S.A., Johann, S., Candinas, D., & Mueller, M.D. (2010). Prognostic value of tumour endothelial markers in patients with endometrial cancer . Oncology Letters, 1, 203-207. https://doi.org/10.3892/ol_00000037
MLA
Bersinger, N. A., Schneider, B., Vorburger, S. A., Johann, S., Candinas, D., Mueller, M. D."Prognostic value of tumour endothelial markers in patients with endometrial cancer ". Oncology Letters 1.1 (2010): 203-207.
Chicago
Bersinger, N. A., Schneider, B., Vorburger, S. A., Johann, S., Candinas, D., Mueller, M. D."Prognostic value of tumour endothelial markers in patients with endometrial cancer ". Oncology Letters 1, no. 1 (2010): 203-207. https://doi.org/10.3892/ol_00000037
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