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Article Open Access

Increased cytochrome c correlates with poor survival in aggressive lymphoma

  • Authors:
    • Sarah T. Wilkinson
    • David B.F. Wilkinson
    • Heather L. Tardif
    • Margaret E. Tome
    • Margaret M. Briehl
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, University of Arizona, Tucson, AZ 85724, USA
  • Pages: 227-230
    |
    Published online on: March 1, 2010
       https://doi.org/10.3892/ol_00000040
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Abstract

Mitochondria are central to a variety of cellular processes, from metabolism to cell death. In this study, we demonstrated that an increase in the critical mitochondrial protein, cytochrome c, correlated with drug resistance in a cell culture model of aggressive lymphoma. Increased cytochrome c expression was also correlated with decreased survival in the aggressive diffuse large B-cell and mantle cell lymphomas, but not in the indolent follicular lymphoma. This suggests that an increased reliance on the mitochondria for energy allows tumor cells to be metabolic opportunists and contribute to tumor development and drug resistance.
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1 

Tome ME and Briehl MM: Thymocytes selected for resistance to hydrogen peroxide show altered antioxidant enzyme profiles and resistance to dexamethasone-induced apoptosis. Cell Death Differ. 8:953–961. 2001. View Article : Google Scholar : PubMed/NCBI

2 

Tome ME, Baker AF, Powis G, Payne CM and Briehl MM: Catalase-overexpressing thymocytes are resistant to glucocorticoid-induced apoptosis and exhibit increased net tumor growth. Cancer Res. 61:2766–2773. 2001.PubMed/NCBI

3 

Tome ME, Lutz NW and Briehl MM: Overexpression of catalase or Bcl-2 alters glucose and energy metabolism concomitant with dexamethasone resistance. Biochim Biophys Acta. 1693:57–72. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Tome ME, Briehl MM and Lutz NW: Increasing the antioxidant defense in WEHI7.2 cells results in a more tumor-like metabolic profile. Int J Mol Med. 15:497–501. 2005.PubMed/NCBI

5 

Newmeyer DD and Ferguson-Miller S: Mitochondria: releasing power for life and unleashing the machineries of death. Cell. 112:481–490. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Wang GQ, Gastman BR, Wieckowski E, Goldstein LA, Rabinovitz A, Yin XM and Rabinowich H: Apoptosis-resistant mitochondria in T cells selected for resistance to Fas signaling. J Biol Chem. 276:3610–3619. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Rosenwald A, Wright G, Chan WC, et al: The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med. 346:1937–1947. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Dave SS, Wright G, Tan B, et al: Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells. N Engl J Med. 351:2159–2169. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Rosenwald A, Wright G, Wiestner A, et al: The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma. Cancer Cell. 3:185–197. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Tome ME, Johnson DB, Rimsza LM, Roberts RA, Grogan TM, Miller TP, Oberley LW and Briehl MM: A redox signature score identifies diffuse large B-cell lymphoma patients with a poor prognosis. Blood. 106:3594–3601. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Igamberdiev AU and Kleczkowski LA: Equilibration of adenylates in the mitochondrial intermembrane space maintains respiration and regulates cytosolic metabolism. J Exp Bot. 57:2133–2141. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Frezza C and Gottlieb E: Mitochondria in cancer: not just innocent bystanders. Semin Cancer Biol. 19:4–11. 2009. View Article : Google Scholar : PubMed/NCBI

13 

King MP and Attardi G: Isolation of human cell lines lacking mitochondrial DNA. Methods Enzymol. 264:304–313. 1996. View Article : Google Scholar : PubMed/NCBI

14 

Rossignol R, Gilkerson R, Aggeler R, Yamagata K, Remington SJ and Capaldi RA: Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells. Cancer Res. 64:985–993. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wilkinson ST, Wilkinson DB, Tardif HL, Tome ME and Briehl MM: Increased cytochrome c correlates with poor survival in aggressive lymphoma . Oncol Lett 1: 227-230, 2010.
APA
Wilkinson, S.T., Wilkinson, D.B., Tardif, H.L., Tome, M.E., & Briehl, M.M. (2010). Increased cytochrome c correlates with poor survival in aggressive lymphoma . Oncology Letters, 1, 227-230. https://doi.org/10.3892/ol_00000040
MLA
Wilkinson, S. T., Wilkinson, D. B., Tardif, H. L., Tome, M. E., Briehl, M. M."Increased cytochrome c correlates with poor survival in aggressive lymphoma ". Oncology Letters 1.2 (2010): 227-230.
Chicago
Wilkinson, S. T., Wilkinson, D. B., Tardif, H. L., Tome, M. E., Briehl, M. M."Increased cytochrome c correlates with poor survival in aggressive lymphoma ". Oncology Letters 1, no. 2 (2010): 227-230. https://doi.org/10.3892/ol_00000040
Copy and paste a formatted citation
x
Spandidos Publications style
Wilkinson ST, Wilkinson DB, Tardif HL, Tome ME and Briehl MM: Increased cytochrome c correlates with poor survival in aggressive lymphoma . Oncol Lett 1: 227-230, 2010.
APA
Wilkinson, S.T., Wilkinson, D.B., Tardif, H.L., Tome, M.E., & Briehl, M.M. (2010). Increased cytochrome c correlates with poor survival in aggressive lymphoma . Oncology Letters, 1, 227-230. https://doi.org/10.3892/ol_00000040
MLA
Wilkinson, S. T., Wilkinson, D. B., Tardif, H. L., Tome, M. E., Briehl, M. M."Increased cytochrome c correlates with poor survival in aggressive lymphoma ". Oncology Letters 1.2 (2010): 227-230.
Chicago
Wilkinson, S. T., Wilkinson, D. B., Tardif, H. L., Tome, M. E., Briehl, M. M."Increased cytochrome c correlates with poor survival in aggressive lymphoma ". Oncology Letters 1, no. 2 (2010): 227-230. https://doi.org/10.3892/ol_00000040
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