Open Access

Increased cytochrome c correlates with poor survival in aggressive lymphoma

  • Authors:
    • Sarah T. Wilkinson
    • David B.F. Wilkinson
    • Heather L. Tardif
    • Margaret E. Tome
    • Margaret M. Briehl
  • View Affiliations

  • Published online on: March 1, 2010     https://doi.org/10.3892/ol_00000040
  • Pages: 227-230
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Abstract

Mitochondria are central to a variety of cellular processes, from metabolism to cell death. In this study, we demonstrated that an increase in the critical mitochondrial protein, cytochrome c, correlated with drug resistance in a cell culture model of aggressive lymphoma. Increased cytochrome c expression was also correlated with decreased survival in the aggressive diffuse large B-cell and mantle cell lymphomas, but not in the indolent follicular lymphoma. This suggests that an increased reliance on the mitochondria for energy allows tumor cells to be metabolic opportunists and contribute to tumor development and drug resistance.
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March-April 2010
Volume 1 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wilkinson ST, Wilkinson DB, Tardif HL, Tome ME and Briehl MM: Increased cytochrome c correlates with poor survival in aggressive lymphoma . Oncol Lett 1: 227-230, 2010
APA
Wilkinson, S.T., Wilkinson, D.B., Tardif, H.L., Tome, M.E., & Briehl, M.M. (2010). Increased cytochrome c correlates with poor survival in aggressive lymphoma . Oncology Letters, 1, 227-230. https://doi.org/10.3892/ol_00000040
MLA
Wilkinson, S. T., Wilkinson, D. B., Tardif, H. L., Tome, M. E., Briehl, M. M."Increased cytochrome c correlates with poor survival in aggressive lymphoma ". Oncology Letters 1.2 (2010): 227-230.
Chicago
Wilkinson, S. T., Wilkinson, D. B., Tardif, H. L., Tome, M. E., Briehl, M. M."Increased cytochrome c correlates with poor survival in aggressive lymphoma ". Oncology Letters 1, no. 2 (2010): 227-230. https://doi.org/10.3892/ol_00000040