α-fetoprotein-producing endometrial adenocarcinoma without an obvious hepatoid component

Kodama,Junichi; Seki,Noriko; Yanai,Hiroyuki; Kusumoto,Tomoyuki; Nakamura,Keiichiro; Hongo,Atsuchi; Hiramatsu,Yugi

doi:10.3892/ol_00000043

α-fetoprotein-producing endometrial adenocarcinoma without an obvious hepatoid component

Authors:
- Junichi Kodama
- Noriko Seki
- Hiroyuki Yanai
- Tomoyuki Kusumoto
- Keiichiro Nakamura
- Atsuchi Hongo
- Yugi Hiramatsu
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Affiliations: Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan
Published online on: March 1, 2010 https://doi.org/10.3892/ol_00000043
Pages: 243-245

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Abstract

Endometrial carcinomas producing α-fetoprotein (AFP) are extremely rare. We report a case of AFP-producing, Grade 2 endometrioid adenocarcinoma without an obvious hepatoid component. A 59-year-old multiparous woman presented with abdominal swelling. The serum level of AFP was 1292.8 ng/ml. Magnetic resonance images of the pelvis showed a markedly enlarged uterus, with a tumor growing exophytically within the endometrial cavity. Total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed. The histopathological examination demonstrated a Stage IIA, Grade 2 endometrioid adenocarcinoma without an obvious hepatoid component. The endometrioid adenocarcinoma cells were partly positive for AFP immunoreactivity. The patient received adjuvant chemotherapy and was disease-free 60 months after the operation. This case confirms the existence of AFP-producing endometrioid adenocarcinomas without hepatoid features.

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