α-fetoprotein-producing endometrial adenocarcinoma without an obvious hepatoid component

Kodama,Junichi; Seki,Noriko; Yanai,Hiroyuki; Kusumoto,Tomoyuki; Nakamura,Keiichiro; Hongo,Atsuchi; Hiramatsu,Yugi

doi:10.3892/ol_00000043

March-April 2010 Volume 1 Issue 2

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March-April 2010 Volume 1 Issue 2

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Article

α-fetoprotein-producing endometrial adenocarcinoma without an obvious hepatoid component

Authors:
- Junichi Kodama
- Noriko Seki
- Hiroyuki Yanai
- Tomoyuki Kusumoto
- Keiichiro Nakamura
- Atsuchi Hongo
- Yugi Hiramatsu
View Affiliations / Copyright

Affiliations: Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan
Pages: 243-245
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Published online on: March 1, 2010

https://doi.org/10.3892/ol_00000043
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Abstract

Endometrial carcinomas producing α-fetoprotein (AFP) are extremely rare. We report a case of AFP-producing, Grade 2 endometrioid adenocarcinoma without an obvious hepatoid component. A 59-year-old multiparous woman presented with abdominal swelling. The serum level of AFP was 1292.8 ng/ml. Magnetic resonance images of the pelvis showed a markedly enlarged uterus, with a tumor growing exophytically within the endometrial cavity. Total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed. The histopathological examination demonstrated a Stage IIA, Grade 2 endometrioid adenocarcinoma without an obvious hepatoid component. The endometrioid adenocarcinoma cells were partly positive for AFP immunoreactivity. The patient received adjuvant chemotherapy and was disease-free 60 months after the operation. This case confirms the existence of AFP-producing endometrioid adenocarcinomas without hepatoid features.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

α-fetoprotein-producing endometrial adenocarcinoma without an obvious hepatoid component

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