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Article

Adjuvant pamidronate therapy prevents the development of bone metastases in breast cancer patients with four or more positive nodes

  • Authors:
    • Ikuo Kokufu
    • Norio Kohno
    • Masayuki Yamamoto
    • Shintaro Takao
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Itami City Hospital, Itami 664-8540, Japan
  • Pages: 247-252
    |
    Published online on: March 1, 2010
       https://doi.org/10.3892/ol_00000044
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Abstract

Bisphosphonates are strongly efficacious in inhibiting osteoclast bone resorption and have beneficial effects on bone metastasis. Due to their mechanism of action, bisphosphonates are expected to prevent the development of bone metastases in breast cancer patients. Pamidronate is a potent inhibitor of osteoclast activity. We examined whether pamidronate was able to prevent the development of bone metastases in breast cancer patients at high risk for bone metastasis. Between 1997 and 2001, 90 patients with primary breast cancer with ≥4 positive nodes were assigned to receive 45 mg pamidronate 4 times every 2 weeks (33 patients) or standard follow-up (57 patients) based on patient self-preference. Patients underwent surgery and adjuvant therapy. The characteristics of the patients in the two groups were well-balanced. The median follow-up period was 5 years. Bone metastases were detected in 12.1% of patients in the pamidronate group and 40.4% in the control group (p=0.005). Distant metastases (36.4 vs. 56.1%, p=0.071) and non-osseous metastases (33.3 vs. 52.6%, p=0.077) were detected at a lower frequency in the pamidronate group. Thus, the rate of bone metastasis-free survival was significantly higher in the pamidronate group (85.9 vs. 64.0% at 5 years, p=0.023). Overall and disease-free survival rates did not differ between the two groups. In the pamidronate group, the incidence of bone metastases was significantly reduced and bone metastasis-free survival was significantly higher. Adjuvant pamidronate therapy therefore prevents the development of bone metastases in breast cancer patients with ≥4 positive nodes.
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Copy and paste a formatted citation
Spandidos Publications style
Kokufu I, Kohno N, Yamamoto M and Takao S: Adjuvant pamidronate therapy prevents the development of bone metastases in breast cancer patients with four or more positive nodes . Oncol Lett 1: 247-252, 2010.
APA
Kokufu, I., Kohno, N., Yamamoto, M., & Takao, S. (2010). Adjuvant pamidronate therapy prevents the development of bone metastases in breast cancer patients with four or more positive nodes . Oncology Letters, 1, 247-252. https://doi.org/10.3892/ol_00000044
MLA
Kokufu, I., Kohno, N., Yamamoto, M., Takao, S."Adjuvant pamidronate therapy prevents the development of bone metastases in breast cancer patients with four or more positive nodes ". Oncology Letters 1.2 (2010): 247-252.
Chicago
Kokufu, I., Kohno, N., Yamamoto, M., Takao, S."Adjuvant pamidronate therapy prevents the development of bone metastases in breast cancer patients with four or more positive nodes ". Oncology Letters 1, no. 2 (2010): 247-252. https://doi.org/10.3892/ol_00000044
Copy and paste a formatted citation
x
Spandidos Publications style
Kokufu I, Kohno N, Yamamoto M and Takao S: Adjuvant pamidronate therapy prevents the development of bone metastases in breast cancer patients with four or more positive nodes . Oncol Lett 1: 247-252, 2010.
APA
Kokufu, I., Kohno, N., Yamamoto, M., & Takao, S. (2010). Adjuvant pamidronate therapy prevents the development of bone metastases in breast cancer patients with four or more positive nodes . Oncology Letters, 1, 247-252. https://doi.org/10.3892/ol_00000044
MLA
Kokufu, I., Kohno, N., Yamamoto, M., Takao, S."Adjuvant pamidronate therapy prevents the development of bone metastases in breast cancer patients with four or more positive nodes ". Oncology Letters 1.2 (2010): 247-252.
Chicago
Kokufu, I., Kohno, N., Yamamoto, M., Takao, S."Adjuvant pamidronate therapy prevents the development of bone metastases in breast cancer patients with four or more positive nodes ". Oncology Letters 1, no. 2 (2010): 247-252. https://doi.org/10.3892/ol_00000044
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