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Article

ATP7B expression is associated with in vitro sensitivity to cisplatin in non-small cell lung cancer

  • Authors:
    • Yoshimasa Inoue
    • Hozumi Matsumoto
    • Shunsuke Yamada
    • Kenji Kawai
    • Hiroshi Suemizu
    • Masatoshi Gika
    • Iwao Takanami
    • Masato Nakamura
    • Masayuki Iwazaki
  • View Affiliations / Copyright

    Affiliations: Department of General Thoracic Surgery, Tokai University Hachioji Hospital, Tokyo 192-0032, Japan
  • Pages: 279-282
    |
    Published online on: March 1, 2010
       https://doi.org/10.3892/ol_00000049
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Abstract

Copper-transporting P-type adenosine triphosphatase (ATP7B) is reportedly associated with platinum drug resistance in various solid tumors. However, the impact of ATP7B on platinum drug resistance in non-small cell lung cancer (NSCLC) remains unclear. We investigated in vitro cisplatin (CDDP) sensitivity using the collagen gel-droplet embedded culture drug sensitivity test. The ATP7B mRNA expression level in each specimen was also examined using real-time polymerase chain reaction. The relationship between ATP7B expression and in vitro CDDP sensitivity was then evaluated. The ATP7B mRNA expression levels in CDDP-resistant tumors were significantly higher than those in the CDDP-sensitive group (p=0.015; Mann-Whitney U test). Our results suggested that ATP7B expression is a promising chemoresistance marker for cisplatin.
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Copy and paste a formatted citation
Spandidos Publications style
Inoue Y, Matsumoto H, Yamada S, Kawai K, Suemizu H, Gika M, Takanami I, Nakamura M and Iwazaki M: ATP7B expression is associated with in vitro sensitivity to cisplatin in non-small cell lung cancer . Oncol Lett 1: 279-282, 2010.
APA
Inoue, Y., Matsumoto, H., Yamada, S., Kawai, K., Suemizu, H., Gika, M. ... Iwazaki, M. (2010). ATP7B expression is associated with in vitro sensitivity to cisplatin in non-small cell lung cancer . Oncology Letters, 1, 279-282. https://doi.org/10.3892/ol_00000049
MLA
Inoue, Y., Matsumoto, H., Yamada, S., Kawai, K., Suemizu, H., Gika, M., Takanami, I., Nakamura, M., Iwazaki, M."ATP7B expression is associated with in vitro sensitivity to cisplatin in non-small cell lung cancer ". Oncology Letters 1.2 (2010): 279-282.
Chicago
Inoue, Y., Matsumoto, H., Yamada, S., Kawai, K., Suemizu, H., Gika, M., Takanami, I., Nakamura, M., Iwazaki, M."ATP7B expression is associated with in vitro sensitivity to cisplatin in non-small cell lung cancer ". Oncology Letters 1, no. 2 (2010): 279-282. https://doi.org/10.3892/ol_00000049
Copy and paste a formatted citation
x
Spandidos Publications style
Inoue Y, Matsumoto H, Yamada S, Kawai K, Suemizu H, Gika M, Takanami I, Nakamura M and Iwazaki M: ATP7B expression is associated with in vitro sensitivity to cisplatin in non-small cell lung cancer . Oncol Lett 1: 279-282, 2010.
APA
Inoue, Y., Matsumoto, H., Yamada, S., Kawai, K., Suemizu, H., Gika, M. ... Iwazaki, M. (2010). ATP7B expression is associated with in vitro sensitivity to cisplatin in non-small cell lung cancer . Oncology Letters, 1, 279-282. https://doi.org/10.3892/ol_00000049
MLA
Inoue, Y., Matsumoto, H., Yamada, S., Kawai, K., Suemizu, H., Gika, M., Takanami, I., Nakamura, M., Iwazaki, M."ATP7B expression is associated with in vitro sensitivity to cisplatin in non-small cell lung cancer ". Oncology Letters 1.2 (2010): 279-282.
Chicago
Inoue, Y., Matsumoto, H., Yamada, S., Kawai, K., Suemizu, H., Gika, M., Takanami, I., Nakamura, M., Iwazaki, M."ATP7B expression is associated with in vitro sensitivity to cisplatin in non-small cell lung cancer ". Oncology Letters 1, no. 2 (2010): 279-282. https://doi.org/10.3892/ol_00000049
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