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Article

Down-regulation of IL-6, IL-8, TNF-α and IL-1β by glucosamine in HaCaT cells, but not in the presence of TNF-α

  • Authors:
    • Kun Park
    • Ji-Hye Lee
    • Ho-Chan Cho
    • Sun-Young Cho
    • Jae-We Cho
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, College of Medicine Eulji University, Seoul, Korea
  • Pages: 289-292
    |
    Published online on: March 1, 2010
       https://doi.org/10.3892/ol_00000051
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Abstract

There is considerable evidence that glucosamine exerts an inhibitory effect on inflammatory cytokine expression in cells. Glucosamine has been recommended as a promising anti-inflammatory modulator, which has been applied in clinical trials for attenuation of the inflammatory process. However, it is unknown whether glucosamine reduces the expression of TNF-α-induced inflammatory cytokines in HaCaT cells. The anti-inflammatory effects of curcumin in HaCaT cells have been extensively investigated in several studies. Thus, in this study we investigated the expression of IL-6, IL-8, TNF-α and IL-1β in glucosamine-treated HaCaT cells, and the effects of glucosamine were compared to those of curcumin-treated HaCaT cells. Our data showed that the expression of IL-6, IL-8, TNF-α and IL-1β was decreased by glucosamine treatment in the HaCaT cells. In contrast, the expression of IL-6, IL-8, TNF-α and IL-1β was not attenuated by glucosamine treatment in the TNF-α-treated HaCaT cells. Notably, curcumin induced an increased expression of IL-8 and IL-1β in the HaCaT cells, but not that of IL-6 and TNF-α. On the other hand, curcumin attenuated the expression of IL-6 and IL-8 in the TNF-α-treated HaCaT cells. Our data indicated that glucosamine induced the down-regulation of IL-6, IL-8, TNF-α and IL-1β expression in the HaCaT cells. However, the stimulation of TNF-α abolished the inhibitory effects of glucosamine on the expression of inflammatory cytokines in the HaCaT cells. Thus, even though glucosamine induces the down-regulation of inflammatory cytokines in HaCaT cells, the anti-inflammatory role of glucosamine in TNF-α-mediated inflammatory skin diseases should be investigated.
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1 

Damjanov N and Vojinovic J: Biologic therapy of rheumatoid arthritis. Srp Arh Celok Lek. 137:205–210. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Ding C, Cicuttini F, Li J and Jones G: Targeting IL-6 in the treatment of inflammatory and autoimmune diseases. Expert Opin Investig Drugs. 18:1457–1466. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Kovarikova M, Hofmanova J, Soucek K and Kozubik A: The effects of TNF-alpha and inhibitors of arachidonic acid metabolism on human colon HT-29 cells depend on differentiation status. Differentiation. 72:23–31. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Carlsen H, Alexander G, Austenaa LM, Ebihara K and Blomhoff R: Molecular imaging of the transcription factor NF-kappaB, a primary regulator of stress response. Mutat Res. 551:199–211. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Muthusamy V and Piva TJ: The UV response of the skin: a review of the MAPK, NFkappaB and TNFalpha signal transduction pathways. Arch Dermatol Res. Sep 16–2009.(Epub ahead of print).

6 

Leng H, Luo X, Ma L, Kang K and Zheng Z: Reversal of ultraviolet B-induced immunosuppression by inhibition of the extracellular signal-regulated mitogen-activated protein kinase. Photodermatol Photoimmunol Photomed. 25:264–269. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Neves BM, Cruz MT, Francisco V, Garcia-Rodriguez C, Silvestre R, Cordeiro-da-Silva A, Dinis AM, Batista MT, Duarte CB and Lopes MC: Differential roles of PI3-kinase, MAPKs and NF-kappaB on the manipulation of dendritic cell T(h)1/T(h)2 cytokine/chemokine polarizing profile. Mol Immunol. 46:2481–2492. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Ivanova IA, Nakrieko KA and Dagnino L: Phosphorylation by p38 MAP kinase is required for E2F1 degradation and keratinocyte differentiation. Oncogene. 28:52–62. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Hong H, Park YK, Choi MS, Ryu NH, Song DK, Suh SI, Nam KY, Park GY and Jang BC: Differential down-regulation of COX-2 and MMP-13 in human skin fibroblasts by glucosamine-hydrochloride. J Dermatol Sci. 56:43–50. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Hwang SM, Chen CY, Chen SS and Chen JC: Chitinous materials inhibit nitric oxide production by activated RAW 264.7 macrophages. Biochem Biophys Res Commun. 271:229–233. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Xing D, Feng W, Not LG, Miller AP, Zhang Y, Chen YF, Majid-Hassan E, Chatham JC and Oparil S: Increased protein O-GlcNAc modification inhibits inflammatory and neointimal responses to acute endoluminal arterial injury. Am J Physiol Heart Circ Physiol. 295:335–342. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Kneass ZT and Marchase RB: Protein O-GlcNAc modulates motility-associated signaling intermediates in neutrophils. J Biol Chem. 280:14579–14585. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Sinha R, Anderson DE, McDonald SS and Greenwald P: Cancer risk and diet in India. J Postgrad Med. 49:222–228. 2003.PubMed/NCBI

14 

Pari L, Tewas D and Eckel J: Role of curcumin in health and disease. Arch Physiol Biochem. 114:127–149. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Jiang ZY, Zou L, Shi SS, Lu YR, Dong J, Yang CH, Lu YC and Dai GK: Effects of curcumin on TNF-alpha and TGF-beta1 in serum and lung tissue of SiO(2)-induced fibrosis in mice. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 25:399–401. 2009.PubMed/NCBI

16 

Reuter S, Charlet J, Juncker T, Teiten MH, Dicato M and Diederich M: Effect of curcumin on nuclear factor kappaB signaling pathways in human chronic myelogenous K562 leukemia cells. Ann NY Acad Sci. 1171:436–447. 2009. View Article : Google Scholar

17 

Wang SL, Li Y, Wen Y, Chen YF, Na LX, Li ST and Sun CH: Curcumin, a potential inhibitor of up-regulation of TNF-alpha and IL-6 induced by palmitate in 3T3-L1 adipocytes through NF-kappaB and JNK pathway. Biomed Environ Sci. 22:32–39. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Rafi MM, Yadav PN and Rossi AO: Glucosamine inhibits LPS-induced COX-2 and iNOS expression in mouse macrophage cells (RAW 264.7) by inhibition of p38-MAP kinase and transcription factor NF-kappaB. Mol Nutr Food Res. 51:587–593. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Chesnokov V, Sun C and Itakura K: Glucosamine suppresses proliferation of human prostate carcinoma DU145 cells through inhibition of STAT3 signaling. Cancer Cell Int. 9:25–28. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Fox BA and Stephens MM: Glucosamine/chondroitin/primorine combination therapy for osteoarthritis. Drugs Today. 45:21–31. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Bonness S and Bieber T: Molecular basis of atopic dermatitis. Curr Opin Allergy Clin Immunol. 7:382–386. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Capon F, Trembath RC and Barker JN: An update on the genetics of psoriasis. Dermatol Clin. 22:339–347. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Deane JA and Hickey MJ: Molecular mechanisms of leukocyte trafficking in T-cell-mediated skin inflammation: insights from intravital imaging. Expert Rev Mol Med. 11:e252009. View Article : Google Scholar : PubMed/NCBI

24 

Escobar J, Pereda J, Arduini A, Sandoval J, Sabater L, Aparisi L, Lopez-Rodas G and Sastre J: Cross-talk between oxidative stress and pro-inflammatory cytokines in acute pancreatitis: a key role for protein phosphatases. Curr Pharm Des. 15:3027–3042. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Park K, Lee J, Cho H, Cho S and Cho J: Down-regulation of IL-6, IL-8, TNF-α and IL-1β by glucosamine in HaCaT cells, but not in the presence of TNF-α . Oncol Lett 1: 289-292, 2010.
APA
Park, K., Lee, J., Cho, H., Cho, S., & Cho, J. (2010). Down-regulation of IL-6, IL-8, TNF-α and IL-1β by glucosamine in HaCaT cells, but not in the presence of TNF-α . Oncology Letters, 1, 289-292. https://doi.org/10.3892/ol_00000051
MLA
Park, K., Lee, J., Cho, H., Cho, S., Cho, J."Down-regulation of IL-6, IL-8, TNF-α and IL-1β by glucosamine in HaCaT cells, but not in the presence of TNF-α ". Oncology Letters 1.2 (2010): 289-292.
Chicago
Park, K., Lee, J., Cho, H., Cho, S., Cho, J."Down-regulation of IL-6, IL-8, TNF-α and IL-1β by glucosamine in HaCaT cells, but not in the presence of TNF-α ". Oncology Letters 1, no. 2 (2010): 289-292. https://doi.org/10.3892/ol_00000051
Copy and paste a formatted citation
x
Spandidos Publications style
Park K, Lee J, Cho H, Cho S and Cho J: Down-regulation of IL-6, IL-8, TNF-α and IL-1β by glucosamine in HaCaT cells, but not in the presence of TNF-α . Oncol Lett 1: 289-292, 2010.
APA
Park, K., Lee, J., Cho, H., Cho, S., & Cho, J. (2010). Down-regulation of IL-6, IL-8, TNF-α and IL-1β by glucosamine in HaCaT cells, but not in the presence of TNF-α . Oncology Letters, 1, 289-292. https://doi.org/10.3892/ol_00000051
MLA
Park, K., Lee, J., Cho, H., Cho, S., Cho, J."Down-regulation of IL-6, IL-8, TNF-α and IL-1β by glucosamine in HaCaT cells, but not in the presence of TNF-α ". Oncology Letters 1.2 (2010): 289-292.
Chicago
Park, K., Lee, J., Cho, H., Cho, S., Cho, J."Down-regulation of IL-6, IL-8, TNF-α and IL-1β by glucosamine in HaCaT cells, but not in the presence of TNF-α ". Oncology Letters 1, no. 2 (2010): 289-292. https://doi.org/10.3892/ol_00000051
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