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Article

Hypermethylation of the large tumor suppressor genes in Japanese lung cancer

  • Authors:
    • Hidefumi Sasaki
    • Yu Hikosaka
    • Osamu Kawano
    • Motoki Yano
    • Yoshitaka Fujii
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Immunology and Surgery, Nagoya City University Medical School, Nagoya 467-8601, Japan
  • Pages: 303-307
    |
    Published online on: March 1, 2010
       https://doi.org/10.3892/ol_00000054
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Abstract

Large tumor suppressor (LATS) 1 and 2 are tumor suppressor genes implicated in the regulation of the cell cycle. The methylation statuses of the promoter regions of these genes were studied in Japanese lung cancers. The methylation statuses of the promoter regions of LATS1 and LATS2 were investigated by methylation-specific PCR. The findings were compared to clinicopathological features of lung cancer. Methylation-specific PCR showed that the LATS1 promoter region was hypermethylated in 95 out of 119 (79.8%) lung cancers. The methylation status of LATS1 was significantly associated with squamous histology (p=0.0267) and smoking status (never smoker vs. smoker; p=0.0399). LATS1-ummethylated patients harbored more EGFR mutations (p=0.0143). The LATS2 promoter region was hypermethylated in 160 out of 203 (78.8%) lung cancers. However, the methylation status had no association with the clinicopathological characteristics of the lung cancers cases. Both the LATS1 and LATS2 methylation statuses did not correlate with survival of lung cancer patients. Thus, the EGFR methylation status of the LATS genes has limited value in Japanese lung cancers.
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Copy and paste a formatted citation
Spandidos Publications style
Sasaki H, Hikosaka Y, Kawano O, Yano M and Fujii Y: Hypermethylation of the large tumor suppressor genes in Japanese lung cancer . Oncol Lett 1: 303-307, 2010.
APA
Sasaki, H., Hikosaka, Y., Kawano, O., Yano, M., & Fujii, Y. (2010). Hypermethylation of the large tumor suppressor genes in Japanese lung cancer . Oncology Letters, 1, 303-307. https://doi.org/10.3892/ol_00000054
MLA
Sasaki, H., Hikosaka, Y., Kawano, O., Yano, M., Fujii, Y."Hypermethylation of the large tumor suppressor genes in Japanese lung cancer ". Oncology Letters 1.2 (2010): 303-307.
Chicago
Sasaki, H., Hikosaka, Y., Kawano, O., Yano, M., Fujii, Y."Hypermethylation of the large tumor suppressor genes in Japanese lung cancer ". Oncology Letters 1, no. 2 (2010): 303-307. https://doi.org/10.3892/ol_00000054
Copy and paste a formatted citation
x
Spandidos Publications style
Sasaki H, Hikosaka Y, Kawano O, Yano M and Fujii Y: Hypermethylation of the large tumor suppressor genes in Japanese lung cancer . Oncol Lett 1: 303-307, 2010.
APA
Sasaki, H., Hikosaka, Y., Kawano, O., Yano, M., & Fujii, Y. (2010). Hypermethylation of the large tumor suppressor genes in Japanese lung cancer . Oncology Letters, 1, 303-307. https://doi.org/10.3892/ol_00000054
MLA
Sasaki, H., Hikosaka, Y., Kawano, O., Yano, M., Fujii, Y."Hypermethylation of the large tumor suppressor genes in Japanese lung cancer ". Oncology Letters 1.2 (2010): 303-307.
Chicago
Sasaki, H., Hikosaka, Y., Kawano, O., Yano, M., Fujii, Y."Hypermethylation of the large tumor suppressor genes in Japanese lung cancer ". Oncology Letters 1, no. 2 (2010): 303-307. https://doi.org/10.3892/ol_00000054
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