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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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May-June 2010 Volume 1 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Epigenetics

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Article

Irinotecan-based combination chemotherapy for metastatic small intestinal adenocarcinoma

  • Authors:
    • Yoshihiro Shibata
    • Eishi Baba
    • Hiroshi Ariyama
    • Shuji Arita
    • Taichi Isobe
    • Hitoshi Kusaba
    • Kenji Mitsugi
    • Shuji Nakano
    • Koichi Akashi
  • View Affiliations / Copyright

    Affiliations: First Department of Internal Medicine and Department of Biosystemic Science of Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
  • Pages: 423-426
    |
    Published online on: May 1, 2010
       https://doi.org/10.3892/ol_00000074
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Abstract

Metastatic small intestinal adenocarcinoma (SIA) is rare among digestive tract malignancies, and a standard therapy has yet to be established. The present study described a patient who was treated with irinotecan-based chemotherapy. A 67-year-old woman with a long history of anemia was diagnosed as having SIA using small bowel endoscopy. Tumor invasion of the mesentery and multiple metastases to the lungs and peritoneal lymph nodes were detected. Nine courses of chemotherapy, each consisting of bolus infusion of 5-fluorouracil at 500 mg/m2, plus infusion of irinotecan at 100 mg/m2 with l-leucovorin at 20 mg/m2 on days 1, 8 and 15, were administered at 4-weekly intervals postoperatively. After two courses, the metastatic nodules in the lungs showed a decrease in number and size, and this response continued for over 6 months. Adverse events were manageable during this period. The patient succumbed to the disease 12 months after the initial diagnosis. The present results therefore suggest that irinotecan-based chemotherapy is a potential treatment for metastatic SIA.
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Copy and paste a formatted citation
Spandidos Publications style
Shibata Y, Baba E, Ariyama H, Arita S, Isobe T, Kusaba H, Mitsugi K, Nakano S and Akashi K: Irinotecan-based combination chemotherapy for metastatic small intestinal adenocarcinoma . Oncol Lett 1: 423-426, 2010.
APA
Shibata, Y., Baba, E., Ariyama, H., Arita, S., Isobe, T., Kusaba, H. ... Akashi, K. (2010). Irinotecan-based combination chemotherapy for metastatic small intestinal adenocarcinoma . Oncology Letters, 1, 423-426. https://doi.org/10.3892/ol_00000074
MLA
Shibata, Y., Baba, E., Ariyama, H., Arita, S., Isobe, T., Kusaba, H., Mitsugi, K., Nakano, S., Akashi, K."Irinotecan-based combination chemotherapy for metastatic small intestinal adenocarcinoma ". Oncology Letters 1.3 (2010): 423-426.
Chicago
Shibata, Y., Baba, E., Ariyama, H., Arita, S., Isobe, T., Kusaba, H., Mitsugi, K., Nakano, S., Akashi, K."Irinotecan-based combination chemotherapy for metastatic small intestinal adenocarcinoma ". Oncology Letters 1, no. 3 (2010): 423-426. https://doi.org/10.3892/ol_00000074
Copy and paste a formatted citation
x
Spandidos Publications style
Shibata Y, Baba E, Ariyama H, Arita S, Isobe T, Kusaba H, Mitsugi K, Nakano S and Akashi K: Irinotecan-based combination chemotherapy for metastatic small intestinal adenocarcinoma . Oncol Lett 1: 423-426, 2010.
APA
Shibata, Y., Baba, E., Ariyama, H., Arita, S., Isobe, T., Kusaba, H. ... Akashi, K. (2010). Irinotecan-based combination chemotherapy for metastatic small intestinal adenocarcinoma . Oncology Letters, 1, 423-426. https://doi.org/10.3892/ol_00000074
MLA
Shibata, Y., Baba, E., Ariyama, H., Arita, S., Isobe, T., Kusaba, H., Mitsugi, K., Nakano, S., Akashi, K."Irinotecan-based combination chemotherapy for metastatic small intestinal adenocarcinoma ". Oncology Letters 1.3 (2010): 423-426.
Chicago
Shibata, Y., Baba, E., Ariyama, H., Arita, S., Isobe, T., Kusaba, H., Mitsugi, K., Nakano, S., Akashi, K."Irinotecan-based combination chemotherapy for metastatic small intestinal adenocarcinoma ". Oncology Letters 1, no. 3 (2010): 423-426. https://doi.org/10.3892/ol_00000074
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