Role of vascular endothelial growth factor receptor-3/Flt-4 in early-stage cervical cancer

Zhang,Shiqian; Yu,Hao; Zhang,Linlin

doi:10.3892/ol_00000080

May-June 2010 Volume 1 Issue 3

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May-June 2010 Volume 1 Issue 3

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Article

Role of vascular endothelial growth factor receptor-3/Flt-4 in early-stage cervical cancer

Authors:
- Shiqian Zhang
- Hao Yu
- Linlin Zhang
View Affiliations / Copyright

Affiliations: Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Shandong 250012, P.R. China. zhangshiqian370112@126.com
Pages: 453-456
|
Published online on: May 1, 2010

https://doi.org/10.3892/ol_00000080
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Abstract

The present study was designed to investigate the role of vascular endothelial growth factor receptor (VEGFR)-3/Flt-4 in the early stages of cervical cancer. VEGFR-3/Flt-4 expression, vascular endothelial growth factor (VEGF)-C and VEGF-D in the early stages (Ia-IIa) of cervical cancer in 41 patients was examined by immunohistochemical analysis. Additionally, the VEGFR-3/Flt-4-marked vascular density (MVD) was examined and the relationship of these factors with clinicopathological factors was analyzed. VEGFR-3/Flt-4 was found to be expressed in lymphatic endothelial cells and, to a certain extent, in vascular endothelial cells. The VEGFR-3/Flt-4-positive vessels were largely distributed in the stroma surrounding the tumor tissues, and these vessels were morphologically divided into blood and lymphatic vessels, respectively. Cancer cells were found to express VEGF-C, VEGF-D and VEGFR-3/Flt-4, and their positive expression rate was 48.7% (20/41), 58.5% (24/41) and 63.4% (26/41), respectively. VEGFR-3/Flt-4 expression in the cancer cells of the cervical cancer patients in our study was found to be correlated to the clinical stage, lymph node metastasis, lymphatic invasion and expression of VEGF-C and VEGF-D. However, this expression was unrelated to menstrual status, histological grade and histological classification. MVD was correlated to the clinical stage and expression of VEGF-C and VEGF-D, but was unrelated to menstrual status, histological grade, histological classification, lymph node metastasis and lymphatic invasion. In conclusion, VEGFR-3/Flt-4 plays an important role in the early stages of cervical cancer.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Role of vascular endothelial growth factor receptor-3/Flt-4 in early-stage cervical cancer

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