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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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May-June 2010 Volume 1 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Resveratrol-induced autophagy in human U373 glioma cells

  • Authors:
    • Midori Yamamoto
    • Satoshi O. Suzuki
    • Masaru Himeno
  • View Affiliations / Copyright

    Affiliations: Division of Pharmaceutical Cell Biology, Faculty of Pharmaceutical Sciences, Nagasaki International University, Nagasaki 859-3298, Japan. midori-y@niu.ac.jp
  • Pages: 489-493
    |
    Published online on: May 1, 2010
       https://doi.org/10.3892/ol_00000086
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Abstract

Autophagy is an intracellular protein transport process leading to the degradation of organelles and long-lived proteins in eukaryotes. The down-regulation of autophagy observed in cancer cells has been associated with tumor progression. This study investigated autophagy induced by resveratrol, a natural compound, in human glioma cells. Glioma cells were exposed to resveratrol, and the cell growth and autophagic level were evaluated. Resveratrol inhibited growth and induced cell death in U373 glioma cells. When treated with resveratrol, glioma cells stably expressing GFP fused to LC3, recruited more GFP-LC3-labeled autophagosomes, and the percentage of cells with GFP-LC3-labeled autophagosomes increased. Furthermore, in resveratrol-treated glioma cells, pretreatment with P38 or ERK1/2 inhibitors reduced the autophagic level, suggesting that resveratrol-induced autophagy was positively regulated by P38 and the ERK1/2 pathway. The Akt/mTOR pathway was not involved in resveratrol-induced autophagy. Our results suggest that resveratrol has an anticancer effect on glioma cells by inducing autophagy.
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Copy and paste a formatted citation
Spandidos Publications style
Yamamoto M, Suzuki SO and Himeno M: Resveratrol-induced autophagy in human U373 glioma cells . Oncol Lett 1: 489-493, 2010.
APA
Yamamoto, M., Suzuki, S.O., & Himeno, M. (2010). Resveratrol-induced autophagy in human U373 glioma cells . Oncology Letters, 1, 489-493. https://doi.org/10.3892/ol_00000086
MLA
Yamamoto, M., Suzuki, S. O., Himeno, M."Resveratrol-induced autophagy in human U373 glioma cells ". Oncology Letters 1.3 (2010): 489-493.
Chicago
Yamamoto, M., Suzuki, S. O., Himeno, M."Resveratrol-induced autophagy in human U373 glioma cells ". Oncology Letters 1, no. 3 (2010): 489-493. https://doi.org/10.3892/ol_00000086
Copy and paste a formatted citation
x
Spandidos Publications style
Yamamoto M, Suzuki SO and Himeno M: Resveratrol-induced autophagy in human U373 glioma cells . Oncol Lett 1: 489-493, 2010.
APA
Yamamoto, M., Suzuki, S.O., & Himeno, M. (2010). Resveratrol-induced autophagy in human U373 glioma cells . Oncology Letters, 1, 489-493. https://doi.org/10.3892/ol_00000086
MLA
Yamamoto, M., Suzuki, S. O., Himeno, M."Resveratrol-induced autophagy in human U373 glioma cells ". Oncology Letters 1.3 (2010): 489-493.
Chicago
Yamamoto, M., Suzuki, S. O., Himeno, M."Resveratrol-induced autophagy in human U373 glioma cells ". Oncology Letters 1, no. 3 (2010): 489-493. https://doi.org/10.3892/ol_00000086
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