Reduced expression of claudin-7 is associated with poor outcome in non-small cell lung cancer

  • Authors:
    • Taketsugu Yamamoto
    • Takashi Oshima
    • Kazue Yoshihara
    • Sumitaka Yamanaka
    • Teppei Nishii
    • Hiromasa Arai
    • Kenji Inui
    • Takeshi Kaneko
    • Akinori Nozawa
    • Tetsukan Woo
    • Yasushi Rino
    • Munetaka Masuda
    • Toshio Imada
  • View Affiliations

  • Published online on: May 1, 2010     https://doi.org/10.3892/ol_00000088
  • Pages: 501-505
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Abstract

Claudin-7 is a tight junction protein that plays an important role in tumorigenesis, tumor invasion and metastasis. We examined the clinical significance of claudin-7 expression in 75 postsurgical non-small cell lung cancer (NSCLC) patients. Claudin-7 expression was measured immunohistochemically and was found to be high in 25 patients (33.3%) and low in 50 (66.7%). Survival was significantly poorer in patients with claudin-7-low than in those with claudin-7-high NSCLCs (P=0.024). In particular, survival was significantly poorer in patients with claudin-7-low than in those with claudin-7-high squamous cell carcinomas (P=0.011). A reduced expression of claudin-7 was associated with poor outcome in NSCLCs. Claudin-7 may thus be a useful biomarker and a potential therapeutic target in patients with NSCLC.
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May-June 2010
Volume 1 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yamamoto T, Oshima T, Yoshihara K, Yamanaka S, Nishii T, Arai H, Inui K, Kaneko T, Nozawa A, Woo T, Woo T, et al: Reduced expression of claudin-7 is associated with poor outcome in non-small cell lung cancer . Oncol Lett 1: 501-505, 2010.
APA
Yamamoto, T., Oshima, T., Yoshihara, K., Yamanaka, S., Nishii, T., Arai, H. ... Imada, T. (2010). Reduced expression of claudin-7 is associated with poor outcome in non-small cell lung cancer . Oncology Letters, 1, 501-505. https://doi.org/10.3892/ol_00000088
MLA
Yamamoto, T., Oshima, T., Yoshihara, K., Yamanaka, S., Nishii, T., Arai, H., Inui, K., Kaneko, T., Nozawa, A., Woo, T., Rino, Y., Masuda, M., Imada, T."Reduced expression of claudin-7 is associated with poor outcome in non-small cell lung cancer ". Oncology Letters 1.3 (2010): 501-505.
Chicago
Yamamoto, T., Oshima, T., Yoshihara, K., Yamanaka, S., Nishii, T., Arai, H., Inui, K., Kaneko, T., Nozawa, A., Woo, T., Rino, Y., Masuda, M., Imada, T."Reduced expression of claudin-7 is associated with poor outcome in non-small cell lung cancer ". Oncology Letters 1, no. 3 (2010): 501-505. https://doi.org/10.3892/ol_00000088