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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

MicroRNA-mediated regulation of pancreatic cancer cell proliferation

  • Authors:
    • Aruna Basu
    • Xin Jiang
    • Massimo Negrini
    • Subrata Haldar
  • View Affiliations / Copyright

    Affiliations: Center for Biomedical Sciences, Department of Pharmacology, Case Comprehensive Cancer Center, MetroHealth Campus, R456, Rammelkamp Building, MetroHealth Medical Center, Cleveland, OH 44109, USA
  • Pages: 565-568
    |
    Published online on: May 1, 2010
       https://doi.org/10.3892/ol_00000100
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Abstract

MicroRNAs (miRNAs) comprising 19-25 nucleotides are highly conserved small non-coding RNAs which regulate normal gene expression during development, cell proliferation and apoptosis by targeting mRNAs of protein-coding genes at the post-transcriptional level. Prevalent studies suggest that some human miRNAs, such as miRNA-16, are deregulated in human cancer and behave as tumor suppressors. The overall objective of our investigation was to assess whether miRNA-16 (miR-16) is involved in the regulation of critical genes, such as BCL2, that control the sensitivity of pancreatic cancer cells to apoptosis. This study showed that the ectopic overexpression of miR-16 may be therapeutically beneficial as is evidenced by impaired cell survival with concomitant attenuation of anti-apoptotic protein Bcl-2. Moreover, the luciferase reporter assay suggested that miR-16 post-transcriptionally regulates Bcl-2 expression in pancreatic cancer cells through the target sites of the 3' untranslated region of this gene.
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Copy and paste a formatted citation
Spandidos Publications style
Basu A, Jiang X, Negrini M and Haldar S: MicroRNA-mediated regulation of pancreatic cancer cell proliferation . Oncol Lett 1: 565-568, 2010.
APA
Basu, A., Jiang, X., Negrini, M., & Haldar, S. (2010). MicroRNA-mediated regulation of pancreatic cancer cell proliferation . Oncology Letters, 1, 565-568. https://doi.org/10.3892/ol_00000100
MLA
Basu, A., Jiang, X., Negrini, M., Haldar, S."MicroRNA-mediated regulation of pancreatic cancer cell proliferation ". Oncology Letters 1.3 (2010): 565-568.
Chicago
Basu, A., Jiang, X., Negrini, M., Haldar, S."MicroRNA-mediated regulation of pancreatic cancer cell proliferation ". Oncology Letters 1, no. 3 (2010): 565-568. https://doi.org/10.3892/ol_00000100
Copy and paste a formatted citation
x
Spandidos Publications style
Basu A, Jiang X, Negrini M and Haldar S: MicroRNA-mediated regulation of pancreatic cancer cell proliferation . Oncol Lett 1: 565-568, 2010.
APA
Basu, A., Jiang, X., Negrini, M., & Haldar, S. (2010). MicroRNA-mediated regulation of pancreatic cancer cell proliferation . Oncology Letters, 1, 565-568. https://doi.org/10.3892/ol_00000100
MLA
Basu, A., Jiang, X., Negrini, M., Haldar, S."MicroRNA-mediated regulation of pancreatic cancer cell proliferation ". Oncology Letters 1.3 (2010): 565-568.
Chicago
Basu, A., Jiang, X., Negrini, M., Haldar, S."MicroRNA-mediated regulation of pancreatic cancer cell proliferation ". Oncology Letters 1, no. 3 (2010): 565-568. https://doi.org/10.3892/ol_00000100
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