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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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July-August 2010 Volume 1 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Review

Advances in the research on lymphangiogenesis in carcinoma tissues (Review)

  • Authors:
    • Xiaofei Qiu
    • Shujuan Yao
    • Shiqian Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Gynaecology and Obstetrics, The Centre People's Hospital of Tengzhou, Tengzhou 277500, P.R. China
  • Pages: 579-582
    |
    Published online on: July 1, 2010
       https://doi.org/10.3892/ol_00000102
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Abstract

Metastatic spread of tumors is an important prognostic factor for cancer patients. The effect of angiogenesis on cancer cell proliferation and metastatic spread has been confirmed. However, less attention has been focused on research involving tumor lymphangiogenesis as opposed to research on tumor angiogenesis, due to the lack of specific markers for lymphatic vessel endothelial cells (LVECs). Recently, the improvement of isolation techniques for LVECs and the discovery of specific LVEC markers such as vascular endothelial growth factor receptor-3 (VEGFR-3), podoplanin, lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) and Prox1 have led to advances in research involving lymphangiogenesis in carcinoma tissues. New lymphatic vessels in tumor tissues may originate from bone marrow endothelial progenitor cells, directly from the preexisting lymphatic vessels, and even by cell transformation. Peritumoral lymphatic vessels play a more important role in the process of tumor metastasis by providing more channels for lymphatic invasion and metastatic spread. The molecular mechanism of tumor lymphangiogenesis is complicated, and numerous factors such as VEGF-A, platelet-derived growth factors (PDGFs), hepatocyte growth factor (HGF), fibroblast growth factor-2 (FGF-2), and angiopoietins (Ang) are directly or indirectly involved in the process. However, it has been demonstrated that the VEGF-C/VEGF-D/VEGFR-3 signaling pathways are the most important mechanism underlying tumor lymphangiogenesis.
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Copy and paste a formatted citation
Spandidos Publications style
Qiu X, Yao S and Zhang S: Advances in the research on lymphangiogenesis in carcinoma tissues (Review). Oncol Lett 1: 579-582, 2010.
APA
Qiu, X., Yao, S., & Zhang, S. (2010). Advances in the research on lymphangiogenesis in carcinoma tissues (Review). Oncology Letters, 1, 579-582. https://doi.org/10.3892/ol_00000102
MLA
Qiu, X., Yao, S., Zhang, S."Advances in the research on lymphangiogenesis in carcinoma tissues (Review)". Oncology Letters 1.4 (2010): 579-582.
Chicago
Qiu, X., Yao, S., Zhang, S."Advances in the research on lymphangiogenesis in carcinoma tissues (Review)". Oncology Letters 1, no. 4 (2010): 579-582. https://doi.org/10.3892/ol_00000102
Copy and paste a formatted citation
x
Spandidos Publications style
Qiu X, Yao S and Zhang S: Advances in the research on lymphangiogenesis in carcinoma tissues (Review). Oncol Lett 1: 579-582, 2010.
APA
Qiu, X., Yao, S., & Zhang, S. (2010). Advances in the research on lymphangiogenesis in carcinoma tissues (Review). Oncology Letters, 1, 579-582. https://doi.org/10.3892/ol_00000102
MLA
Qiu, X., Yao, S., Zhang, S."Advances in the research on lymphangiogenesis in carcinoma tissues (Review)". Oncology Letters 1.4 (2010): 579-582.
Chicago
Qiu, X., Yao, S., Zhang, S."Advances in the research on lymphangiogenesis in carcinoma tissues (Review)". Oncology Letters 1, no. 4 (2010): 579-582. https://doi.org/10.3892/ol_00000102
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