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Potassium octatitanate fibers (TISMO) induce pleural mesothelial cell reactions with iron accumulation in female A/J mice

  • Authors:
    • Masanao Yokohira
    • Nozomi Hashimoto
    • Keiko Yamakawa
    • Satoshi Suzuki
    • Kousuke Saoo
    • Toshiya Kuno
    • Katsumi Imaida
  • View Affiliations / Copyright

    Affiliations: Onco-Pathology, Department of Pathology and Host-Defense, Kagawa University, Kagawa 761-0793, Japan
  • Pages: 589-594
    |
    Published online on: July 1, 2010
       https://doi.org/10.3892/ol_00000104
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Abstract

It is crucial to develop therapeutic approaches for malignant mesothelioma, as well as to obtain information involving the possible mechanism involved in the development of mesothelioma. Subsequently, thoracotomy was performed to infuse test particles directly into the thoracic cavity of A/J mice. Fiber-shaped particles of potassium octatitanate (TISMO) and granular-shaped micro- and nano-size order particles of titanium dioxide (TiO2) were employed (1.5 mg in 0.2 ml saline/mouse). The experiment was terminated after 21 weeks to assess responses. Only the fiber-shaped TISMO, morphologically similar to asbestos, induced a severe reaction of the pleura. A number of TISMO fibers were observed in the alveoli, indicating penetration through the pleura. Following Berlin blue staining, positive spots were observed around the TISMO fibers, indicative of iron. These positive spots corresponded with cells that immunostained positively for calretinin, a marker of mesothelial cells. Similar observations were reported for asbestos-induced mesothelioma. The present study showed that only fiber-shaped TISMO induced severe reactions of the mesothelium in the pleura, and these involved iron accumulation derived from endogenous sources. The results indicate that the risk of mesothelial cell reaction does not depend on particle size, but may depend on shape.
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Copy and paste a formatted citation
Spandidos Publications style
Yokohira M, Hashimoto N, Yamakawa K, Suzuki S, Saoo K, Kuno T and Imaida K: Potassium octatitanate fibers (TISMO) induce pleural mesothelial cell reactions with iron accumulation in female A/J mice . Oncol Lett 1: 589-594, 2010.
APA
Yokohira, M., Hashimoto, N., Yamakawa, K., Suzuki, S., Saoo, K., Kuno, T., & Imaida, K. (2010). Potassium octatitanate fibers (TISMO) induce pleural mesothelial cell reactions with iron accumulation in female A/J mice . Oncology Letters, 1, 589-594. https://doi.org/10.3892/ol_00000104
MLA
Yokohira, M., Hashimoto, N., Yamakawa, K., Suzuki, S., Saoo, K., Kuno, T., Imaida, K."Potassium octatitanate fibers (TISMO) induce pleural mesothelial cell reactions with iron accumulation in female A/J mice ". Oncology Letters 1.4 (2010): 589-594.
Chicago
Yokohira, M., Hashimoto, N., Yamakawa, K., Suzuki, S., Saoo, K., Kuno, T., Imaida, K."Potassium octatitanate fibers (TISMO) induce pleural mesothelial cell reactions with iron accumulation in female A/J mice ". Oncology Letters 1, no. 4 (2010): 589-594. https://doi.org/10.3892/ol_00000104
Copy and paste a formatted citation
x
Spandidos Publications style
Yokohira M, Hashimoto N, Yamakawa K, Suzuki S, Saoo K, Kuno T and Imaida K: Potassium octatitanate fibers (TISMO) induce pleural mesothelial cell reactions with iron accumulation in female A/J mice . Oncol Lett 1: 589-594, 2010.
APA
Yokohira, M., Hashimoto, N., Yamakawa, K., Suzuki, S., Saoo, K., Kuno, T., & Imaida, K. (2010). Potassium octatitanate fibers (TISMO) induce pleural mesothelial cell reactions with iron accumulation in female A/J mice . Oncology Letters, 1, 589-594. https://doi.org/10.3892/ol_00000104
MLA
Yokohira, M., Hashimoto, N., Yamakawa, K., Suzuki, S., Saoo, K., Kuno, T., Imaida, K."Potassium octatitanate fibers (TISMO) induce pleural mesothelial cell reactions with iron accumulation in female A/J mice ". Oncology Letters 1.4 (2010): 589-594.
Chicago
Yokohira, M., Hashimoto, N., Yamakawa, K., Suzuki, S., Saoo, K., Kuno, T., Imaida, K."Potassium octatitanate fibers (TISMO) induce pleural mesothelial cell reactions with iron accumulation in female A/J mice ". Oncology Letters 1, no. 4 (2010): 589-594. https://doi.org/10.3892/ol_00000104
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