Examination of the clinical usefulness of TS-1 in locally recurrent breast cancer

  • Authors:
    • Takehiro Nohara
    • Mitsuhiko Iwamoto
    • Kazhuhiro Sumiyoshi
    • Satoru Tanaka
    • Kosei Kimura
    • Yuko Takahashi
    • Nobuhiko Tanigawa
  • View Affiliations

  • Published online on: July 1, 2010     https://doi.org/10.3892/ol_00000117
  • Pages: 669-672
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

This study examined the therapeutic efficacy of TS-1 in the treatment of locally recurrent breast cancer. Between August 2006 and May 2009, 7 patients with local breast cancer recurrences were selected included in the study. The sites of recurrence were the cervical lymph nodes in 4 patients, the axillary lymph nodes in 2 and the thoracic wall in 1. Among the 7 patients, 6 were administered TS-1 as first-line treatment and 1 was administered TS-1 as second-line treatment. Complete response (CR) was achieved in 2 patients, 1 achieved partial response, 2 had stable disease (SD), 1 had long SD and 1 had progressive disease. The overall response rate was 43%, and the clinical benefit rate was 57%. A patient with recurrence of breast cancer in the thoracic wall 28 years after surgery also achieved CR following therapy. The only adverse event observed was a case of hand-foot syndrome in 1 patient. No patients withdrew from treatment, and favorable compliance was achieved in the study. The results indicated that TS-1 has the potential to be one of the drugs for first-line treatment of locally recurrent breast cancer.
View Figures
View References

Related Articles

Journal Cover

July-August 2010
Volume 1 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Nohara T, Iwamoto M, Sumiyoshi K, Tanaka S, Kimura K, Takahashi Y and Tanigawa N: Examination of the clinical usefulness of TS-1 in locally recurrent breast cancer . Oncol Lett 1: 669-672, 2010
APA
Nohara, T., Iwamoto, M., Sumiyoshi, K., Tanaka, S., Kimura, K., Takahashi, Y., & Tanigawa, N. (2010). Examination of the clinical usefulness of TS-1 in locally recurrent breast cancer . Oncology Letters, 1, 669-672. https://doi.org/10.3892/ol_00000117
MLA
Nohara, T., Iwamoto, M., Sumiyoshi, K., Tanaka, S., Kimura, K., Takahashi, Y., Tanigawa, N."Examination of the clinical usefulness of TS-1 in locally recurrent breast cancer ". Oncology Letters 1.4 (2010): 669-672.
Chicago
Nohara, T., Iwamoto, M., Sumiyoshi, K., Tanaka, S., Kimura, K., Takahashi, Y., Tanigawa, N."Examination of the clinical usefulness of TS-1 in locally recurrent breast cancer ". Oncology Letters 1, no. 4 (2010): 669-672. https://doi.org/10.3892/ol_00000117