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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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July-August 2010 Volume 1 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Expression of hypoxia-inducible protein 2 in renal cell carcinoma: A promising candidate for molecular targeting therapy

  • Authors:
    • Takashi Seo
    • Ryuichiro Konda
    • Jun Sugimura
    • Kazuhiro Iwasaki
    • Yusuke Nakamura
    • Tomoaki Fujioka
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Iwate Medical University School of Medicine, Morioka, Japan
  • Pages: 697-701
    |
    Published online on: July 1, 2010
       https://doi.org/10.3892/ol_00000122
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Abstract

This study investigated the expression of hypoxia-inducible protein 2 (HIG2), a novel renal cell carcinoma (RCC)-associated molecule and an essential growth factor for RCC, in kidneys to elucidate its clinical significance in RCC. An immunohistochemical study of HIG2 was conducted in 93 surgical samples of RCC tissues and 10 samples of normal kidney tissues obtained after nephrectomies for localized RCC. HIG2 expression was also correlated with clinicopathological characteristics and survival. Only faint or weak immunostaining for HIG2 was observed in normal kidney samples. HIG2 expression was found in 86% of RCC tissues (80/93). When analyzed by histological type, positive staining for HIG2 was detected in all papillary (7/7), chromophobe (1/1) and cyst-associated (3/3) RCC. In contrast, the HIG2 expression was observed in 85% of clear cell (68/80) and 50% of spindle cell (1/2) RCC. Labeling indices were 74.1, 45.4, 39, 24.8 and 12.1% in papillary, spindle, clear cell, cyst-associated and chromophobe RCC, respectively. A significant increase in HIG2 expression was noted in RCC tissues obtained from patients with high stage RCC, lymph node metastasis and high nuclear grade (p<0.001, p<0.02 and p<0.006, respectively). RCC patients with a negative HIG2 staining had prolonged 5-year cancer-specific survival. In conclusion, HIG2 expression was extensively observed in RCC tissues and was higher in advanced RCC, suggesting that HIG2 is a candidate for the development of molecular targeting therapy.
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1 

Weis RH and Lin PY: Kidney cancer: identification of novel targets for therapy. Kidney Int. 69:224–232. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Motzer RJ, Hutson TE, Tomczak P, Michaelson D, Bukowski M, Rixe O, Oudard S, Negrier S, Szczylik C, Kim ST, Chen I, Bycott PW, Baum CM and Figlin RA: Sunitinib vs. interferon alpha in metastatic renal-cell carcinoma. N Engl J Med. 356:115–124. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Kim HL, Seligson D, Liu X, Janzen N, Bui MHT, Yu H, Shi T, Figlin RA, Horvath S and Belldegrun AS: Using protein expression to predict survival in clear cell renal carcinoma. Clin Cancer Res. 10:5464–5471. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Motzer RJ and Bukowski RM: Targeted therapy for metastatic renal cell carcinoma. J Clin Oncol. 24:5601–5608. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Patel PH, Chadalavada RSV, Chaganti RSK and Motzer RJ: Targeting von Hippel-Lindau pathway in renal cell carcinoma. Clin Cancer Res. 12:7215–7220. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Klatte T, Seligson DB, Riggs SB, Leppert JT, Berkman MK, Kleid MD, Hong Yu, Kabbinavar FF, Pantuck AJ and Belldegrun AS: Hypoxia-inducible factor α in clear cell renal cell carcinoma. Clin Cancer Res. 13:7388–7393. 2007.

7 

Togashi A, Katagiri T, Ashida S, Fujioka T, Maruyama O, Wakumoto Y, Sakamoto Y, Fujime M, Kawachi Y, Shuin T and Nakamura Y: Hypoxia-inducible protein2 (HIG2), a novel diagnostic marker for renal cell carcinoma and potential target for molecular therapy. Cancer Res. 65:4817–4826. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Patard JJ, Fergelot P, Karakiewicz PI, Klatte T, Trinh QD, Rioux-Leclecq N, Said JW, Belldegrun AS and Pantuck AJ: Low CAIX expression and absence of VHL gene mutation are associated with tumor aggressiveness and poor survival of clear cell carcinoma. Int J Cancer. 123:395–400. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Yao M, Yoshida M, Kishida T, Nakaigawa N, Baba M, Kobayashi K, Miura T, Moriyama M, Nagashima Y, Nakatani Y, Kubota Y and Kondo K: VHL tumor suppressor gene alterations associated with good prognosis in sporadic clear-cell renal cell carcinoma. J Natl Cancer Inst. 94:1569–1575. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Mizutani Y: Recent advances in molecular targeted therapy for metastatic renal cell carcinoma. Int J Urol. 16:444–448. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Tozawa K, Okamoto T, Kawai N, Hashimoto Y, Hayashi Y and Kohri K: Positive correlation between sialyl Lewis X expression and pathologic findings in renal cell carcinoma. Kidney Int. 67:1391–1396. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Liao SY, Aurelio ON, Jan K, Zavada J and Stanbridge EJ: Identification of the MN/CA9 protein as a reliable diagnostic biomarker of clear cell carcinoma of the kidney. Cancer Res. 57:2827–2831. 1997.PubMed/NCBI

13 

Wykoff CC, Beasley NJP, Watson PH, Turner KJ, Pastrek J, Sibtain A, Wilson GD, Turley H, Talks KL, Maxwell PH, Pugh CW, Ratcliffe PJ and Harris AL: Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Cancer Res. 60:7075–7083. 2000.PubMed/NCBI

14 

Uemura H, Fujumoto K, Tanaka M, Yoshikawa M, Hirano Y, Uejima S, Yoshikawa K and Itoh K: A phase I trial of vaccination of CA9-derived peptides for HLA-A24-positive patients with cytokine-refractory metastatic renal cell carcinoma. Clin Cancer Res. 12:1768–1775. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Davis ID, Wiseman GA, Lee FT, Gansen DN, Hopkins W, Papenfuss AT, Liu Z, Moynihan TJ, Croghan GA, Adjei AA, Hoffman EW, Ingle JN, Old LJ and Scott AM: A phase 1 multiple dose, dose escalation study of cG250 monoclonal antibody in patients with advanced renal cell carcinoma. Cancer Immun. 7:132007.PubMed/NCBI

16 

Leibovich BC, Sheinin Y, Lohse CM, Thompson RH, Cheville JC, Zavada J and Kwon ED: Carbonic anhydrase IX is not an independent predictor of outcome for patients with clear cell renal cell carcinoma. J Clin Oncol. 25:4757–4764. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Seo T, Konda R, Sugimura J, Iwasaki K, Nakamura Y and Fujioka T: Expression of hypoxia-inducible protein 2 in renal cell carcinoma: A promising candidate for molecular targeting therapy . Oncol Lett 1: 697-701, 2010.
APA
Seo, T., Konda, R., Sugimura, J., Iwasaki, K., Nakamura, Y., & Fujioka, T. (2010). Expression of hypoxia-inducible protein 2 in renal cell carcinoma: A promising candidate for molecular targeting therapy . Oncology Letters, 1, 697-701. https://doi.org/10.3892/ol_00000122
MLA
Seo, T., Konda, R., Sugimura, J., Iwasaki, K., Nakamura, Y., Fujioka, T."Expression of hypoxia-inducible protein 2 in renal cell carcinoma: A promising candidate for molecular targeting therapy ". Oncology Letters 1.4 (2010): 697-701.
Chicago
Seo, T., Konda, R., Sugimura, J., Iwasaki, K., Nakamura, Y., Fujioka, T."Expression of hypoxia-inducible protein 2 in renal cell carcinoma: A promising candidate for molecular targeting therapy ". Oncology Letters 1, no. 4 (2010): 697-701. https://doi.org/10.3892/ol_00000122
Copy and paste a formatted citation
x
Spandidos Publications style
Seo T, Konda R, Sugimura J, Iwasaki K, Nakamura Y and Fujioka T: Expression of hypoxia-inducible protein 2 in renal cell carcinoma: A promising candidate for molecular targeting therapy . Oncol Lett 1: 697-701, 2010.
APA
Seo, T., Konda, R., Sugimura, J., Iwasaki, K., Nakamura, Y., & Fujioka, T. (2010). Expression of hypoxia-inducible protein 2 in renal cell carcinoma: A promising candidate for molecular targeting therapy . Oncology Letters, 1, 697-701. https://doi.org/10.3892/ol_00000122
MLA
Seo, T., Konda, R., Sugimura, J., Iwasaki, K., Nakamura, Y., Fujioka, T."Expression of hypoxia-inducible protein 2 in renal cell carcinoma: A promising candidate for molecular targeting therapy ". Oncology Letters 1.4 (2010): 697-701.
Chicago
Seo, T., Konda, R., Sugimura, J., Iwasaki, K., Nakamura, Y., Fujioka, T."Expression of hypoxia-inducible protein 2 in renal cell carcinoma: A promising candidate for molecular targeting therapy ". Oncology Letters 1, no. 4 (2010): 697-701. https://doi.org/10.3892/ol_00000122
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