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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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July-August 2010 Volume 1 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Activating BRAF gene mutations are uncommon in hormone refractory prostate cancer in Caucasian patients

  • Authors:
    • J. Köllermann
    • H. Albrecht
    • T. Schlomm
    • H. Huland
    • M. Graefen
    • C. Bokemeyer
    • R. Simon
    • G. Sauter
    • W. Wilczak
  • View Affiliations / Copyright

    Affiliations: Institute of Pathology, Hubertus Wald Tumorzentrum, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, Germany
  • Pages: 729-732
    |
    Published online on: July 1, 2010
       https://doi.org/10.3892/ol_00000127
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Abstract

Activating mutations in the cytosolic serine/threonine kinase, BRAF, have been reported in a variety of neoplasms. BRAF activation may contribute to tumor growth via activation of the MAP/ERK kinase pathway, and BRAF represents a possible therapeutic target. Activating BRAF mutations were recently reported in approximately 10% of prostate cancer cases in Asian patients. In the present study, 43 hormone refractory prostate cancers were analyzed for BRAF mutations in order to determine whether anti-BRAF therapy is a suitable approach for advanced prostate cancer patients. In all of the studied tumors, BRAF exons 11 and 15 were PCR-amplified and sequenced, including the backward and forward sequences. BRAF mutations were noted only in the positive control tissues, but were not found in any of the 43 analyzed prostate cancers. We conclude that BRAF mutations occur only rarely in prostate cancers in Caucasian patients and are not associated with tumor progression. The application of anti-BRAF therapies may therefore not be beneficial for prostate cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Köllermann J, Albrecht H, Schlomm T, Huland H, Graefen M, Bokemeyer C, Simon R, Sauter G and Wilczak W: Activating BRAF gene mutations are uncommon in hormone refractory prostate cancer in Caucasian patients . Oncol Lett 1: 729-732, 2010.
APA
Köllermann, J., Albrecht, H., Schlomm, T., Huland, H., Graefen, M., Bokemeyer, C. ... Wilczak, W. (2010). Activating BRAF gene mutations are uncommon in hormone refractory prostate cancer in Caucasian patients . Oncology Letters, 1, 729-732. https://doi.org/10.3892/ol_00000127
MLA
Köllermann, J., Albrecht, H., Schlomm, T., Huland, H., Graefen, M., Bokemeyer, C., Simon, R., Sauter, G., Wilczak, W."Activating BRAF gene mutations are uncommon in hormone refractory prostate cancer in Caucasian patients ". Oncology Letters 1.4 (2010): 729-732.
Chicago
Köllermann, J., Albrecht, H., Schlomm, T., Huland, H., Graefen, M., Bokemeyer, C., Simon, R., Sauter, G., Wilczak, W."Activating BRAF gene mutations are uncommon in hormone refractory prostate cancer in Caucasian patients ". Oncology Letters 1, no. 4 (2010): 729-732. https://doi.org/10.3892/ol_00000127
Copy and paste a formatted citation
x
Spandidos Publications style
Köllermann J, Albrecht H, Schlomm T, Huland H, Graefen M, Bokemeyer C, Simon R, Sauter G and Wilczak W: Activating BRAF gene mutations are uncommon in hormone refractory prostate cancer in Caucasian patients . Oncol Lett 1: 729-732, 2010.
APA
Köllermann, J., Albrecht, H., Schlomm, T., Huland, H., Graefen, M., Bokemeyer, C. ... Wilczak, W. (2010). Activating BRAF gene mutations are uncommon in hormone refractory prostate cancer in Caucasian patients . Oncology Letters, 1, 729-732. https://doi.org/10.3892/ol_00000127
MLA
Köllermann, J., Albrecht, H., Schlomm, T., Huland, H., Graefen, M., Bokemeyer, C., Simon, R., Sauter, G., Wilczak, W."Activating BRAF gene mutations are uncommon in hormone refractory prostate cancer in Caucasian patients ". Oncology Letters 1.4 (2010): 729-732.
Chicago
Köllermann, J., Albrecht, H., Schlomm, T., Huland, H., Graefen, M., Bokemeyer, C., Simon, R., Sauter, G., Wilczak, W."Activating BRAF gene mutations are uncommon in hormone refractory prostate cancer in Caucasian patients ". Oncology Letters 1, no. 4 (2010): 729-732. https://doi.org/10.3892/ol_00000127
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