Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-October 2010 Volume 1 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-October 2010 Volume 1 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Metastin has potential as a suitable biomarker and novel effective therapy for cancer metastasis (Review)

  • Authors:
    • Sunao Shoji
    • Xian Yang Tang
    • Haruhiro Sato
    • Yukio Usui
    • Toyoaki Uchida
    • Toshiro Terachi
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan. sunashoj@mail.goo.ne.jp
  • Pages: 783-788
    |
    Published online on: September 1, 2010
       https://doi.org/10.3892/ol_00000136
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cancer metastasis is a leading cause of death in cancer patients and is a multistep process involving complex interactions between tumor and host cells. To metastasize, tumor cells must invade or migrate from the primary tumor and be transported to close or distant secondary sites. A tumor cell should successfully accomplish each step of the pathway or metastasis may not develop. KiSS-1 is a human metastasis suppressor gene that inhibits metastasis of human melanomas and breast carcinomas without affecting tumorigenicity. KiSS-1 encodes a carboxy-terminally amidated peptide with 54 amino-acid residues. The peptide was isolated from human placenta as the endogenous ligand of an orphan G-protein-coupled receptor and termed ‘metastin’. The literature reports metastin related to human carcinoma, such as melanoma, thyroid cancer, esophageal squamous cell carcinoma (ESCC), hepatocellular carcinoma, pancreatic carcinoma, as well as breast, ovarian, bladder and kidney cancer. These malignancies are difficult to treat and, even in early-stage cancer, a number of patients develop metastasis shortly after surgery. Studies have suggested that metastin inhibits tumor invasion or migration through focal adhesion kinase, paxillin, MAP kinase or Rho A. Additionally, metastin may be a biomarker in ESCC, pancreatic carcinoma and bladder cancer. Metastin has potential as a suitable biomarker in the identification of tumors with high metastatic potential and as a novel effective treatment modality for patients with metastasis.
View Figures

Figure 1

View References

1 

Lee JH, Miele ME, Hicks DJ, et al: KiSS-1, a novel human malignant melanoma metastasis-suppressor gene. J Natl Cancer Inst. 88:1731–1737. 1997.PubMed/NCBI

2 

Ohtaki T, Shintani Y, Honda S, et al: Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature. 31:613–617. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Ringel MD, Hardy E, Bernet VJ, et al: Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells. J Clin Endocrinol Metab. 87:23992002. View Article : Google Scholar : PubMed/NCBI

4 

Ikeguchi M, Yamaguchi K and Kaibara N: Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma. Clin Cancer Res. 10:1379–1383. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Ikeguchi M, Hirooka Y and Kaibara N: Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma. J Cancer Res Clin Oncol. 129:531–535. 2003. View Article : Google Scholar

6 

Schmid K, Wang X, Haitel A, et al: KiSS-1 overexpression as an independent prognostic marker in hepatocellular carcinoma: an immunohistochemical study. Virchows Arch. 450:143–149. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Nagai K, Doi R, Katagiri F, et al: Prognostic value of metastin expression in human pancreatic cancer. J Exp Clin Cancer Res. 28:92009. View Article : Google Scholar : PubMed/NCBI

8 

Katagiri F, Nagai K, Kida A, et al: Clinical significance of plasma metastin level in pancreatic cancer patients. Oncol Rep. 21:815–819. 2009.PubMed/NCBI

9 

Martin TA, Watkins G and Jiang WG: KiSS-1 expression in human breast cancer. Clin Exp Metastasis. 22:503–511. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Hata K, Dhar DK, Watanabe Y, et al: Expression of metastin and a G-protein-coupled receptor (AXOR12) in epithelial ovarian cancer. Eur J Cancer. 43:1452–1459. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Sanchez-Carbayo M, Capodieci P and Cordon-Cardo C: Tumor suppressor role of KiSS-1 in bladder cancer: loss of KiSS-1 expression is associated with bladder cancer progression and clinical outcome. Am J Pathol. 162:609–617. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Nicolle G, Comperat E, Nicolaïew N, et al: Metastin (KISS-1) and metastin-coupled receptor (GPR54) expression in transitional cell carcinoma of the bladder. Ann Oncol. 18:605–607. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Shoji S, Tang XY, Umemura S, et al: Metastin inhibits migration and invasion of renal cell carcinoma with overexpression of metastin receptor. Eur Urol. 55:441–449. 2009. View Article : Google Scholar

14 

Harms JF, Welch DR and Miele ME: KISS1 metastasis suppression and emergent pathways. Clin Exp Metastasis. 20:11–18. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Liotta LA, Thorgeirsson UP and Garbisa S: Role of collagenases in tumor cell invasion. Cancer Metastasis Rev. 1:277–288. 1982. View Article : Google Scholar : PubMed/NCBI

16 

Fisher KE, Sacharidou A, Stratman AN, et al: MT1-MMP- and Cdc42-dependent signaling co-regulate cell invasion and tunnel formation in 3D collagen matrices. J Cell Sci. 122:4558–4569. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Takino T, Koshikawa N, Miyamori H, et al: Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases. Oncogene. 22:4617–4626. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Masui T, Doi R, Mori T, et al: Metastin and its variant forms suppress migration of pancreatic cancer cells. Biochem Biophys Res Commun. 315:85–92. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Sobin L and Witte KC: Anonymous: Pancreas. TNM Classification of Malignant Tumours. Wiley-Lewis; New York: pp. 93–96. 2002

20 

Muir AI, Chamberlain L, Elshourbagy NA, et al: AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1. J Biol Chem. 276:28969–28975. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Teloken PE, Thompson RH, Tickoo SK, et al: Prognostic impact of histological subtype on surgically treated localized renal cell carcinoma. J Urol. 182:2132–2136. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Turcotte S, Desrosiers RR and Beliveau R: Hypoxia upregulates von Hippel-Lindau tumor-suppressor protein through RhoA-dependent activity in renal cell carcinoma. Am J Physiol Renal Physiol. 286:F338–F348. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Narumiya S: The small GTPase Rho: cellular functions and signal transduction. J Biochem. 120:215–218. 1996. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Shoji S, Tang XY, Sato H, Usui Y, Uchida T and Terachi T: Metastin has potential as a suitable biomarker and novel effective therapy for cancer metastasis (Review) . Oncol Lett 1: 783-788, 2010.
APA
Shoji, S., Tang, X.Y., Sato, H., Usui, Y., Uchida, T., & Terachi, T. (2010). Metastin has potential as a suitable biomarker and novel effective therapy for cancer metastasis (Review) . Oncology Letters, 1, 783-788. https://doi.org/10.3892/ol_00000136
MLA
Shoji, S., Tang, X. Y., Sato, H., Usui, Y., Uchida, T., Terachi, T."Metastin has potential as a suitable biomarker and novel effective therapy for cancer metastasis (Review) ". Oncology Letters 1.5 (2010): 783-788.
Chicago
Shoji, S., Tang, X. Y., Sato, H., Usui, Y., Uchida, T., Terachi, T."Metastin has potential as a suitable biomarker and novel effective therapy for cancer metastasis (Review) ". Oncology Letters 1, no. 5 (2010): 783-788. https://doi.org/10.3892/ol_00000136
Copy and paste a formatted citation
x
Spandidos Publications style
Shoji S, Tang XY, Sato H, Usui Y, Uchida T and Terachi T: Metastin has potential as a suitable biomarker and novel effective therapy for cancer metastasis (Review) . Oncol Lett 1: 783-788, 2010.
APA
Shoji, S., Tang, X.Y., Sato, H., Usui, Y., Uchida, T., & Terachi, T. (2010). Metastin has potential as a suitable biomarker and novel effective therapy for cancer metastasis (Review) . Oncology Letters, 1, 783-788. https://doi.org/10.3892/ol_00000136
MLA
Shoji, S., Tang, X. Y., Sato, H., Usui, Y., Uchida, T., Terachi, T."Metastin has potential as a suitable biomarker and novel effective therapy for cancer metastasis (Review) ". Oncology Letters 1.5 (2010): 783-788.
Chicago
Shoji, S., Tang, X. Y., Sato, H., Usui, Y., Uchida, T., Terachi, T."Metastin has potential as a suitable biomarker and novel effective therapy for cancer metastasis (Review) ". Oncology Letters 1, no. 5 (2010): 783-788. https://doi.org/10.3892/ol_00000136
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team