Platelet 12-lipoxygenase and stem cells in Barrett's esophagus

Jaskiewicz,Kazimierz; Izycka-Swieszewska,Ewa; Janiak,Maria; Lysiak-Szydlowska,Wieslawa; Adrych,Krystian; Reinartz,Jeannette; Jankun,Jerzy; Skrzypczak-Jankun,Ewa

doi:10.3892/ol_00000137

September-October 2010 Volume 1 Issue 5

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September-October 2010 Volume 1 Issue 5

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Article

Platelet 12-lipoxygenase and stem cells in Barrett's esophagus

Authors:
- Kazimierz Jaskiewicz
- Ewa Izycka-Swieszewska
- Maria Janiak
- Wieslawa Lysiak-Szydlowska
- Krystian Adrych
- Jeannette Reinartz
- Jerzy Jankun
- Ewa Skrzypczak-Jankun
View Affiliations / Copyright

Affiliations: Department of Pathology, Medical University of Gda__AMB__nacute;sk, Gda__AMB__nacute;sk, Poland
Pages: 789-791
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Published online on: September 1, 2010

https://doi.org/10.3892/ol_00000137
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Abstract

Esophageal adenocarcinoma has shown a significant increase in incidence in recent years. It is thought that the development of gastroesophageal reflux disease (GERD), followed by columnar-lined esophagus and the development of dysplasia, leads to invasive adenocarcinoma. The exact pathogenesis of this process, the diagnosis and differentiation of the metaplastic and dysplastic esophageal lesions have yet to be determined. The purpose of this immunohistochemical study was to investigate the expression of pro-tumorigenic enzyme platelet 12-lipoxygenase (p12LOX) using two new available antibodies in non-dysplastic and dysplastic Barrett's esophagus. The stem cell markers nestin, CD117 and CD44, were then evaluated. The comparative group included GERD carditis, gastric intestinal metaplasia and colorectal adenoma. The overexpression of p12LOX detected by two specific antibodies in the non-dysplastic and dysplastic Barrett's mucosa clearly demonstrated that this enzyme plays an important role in the development of esophageal adenocarcinoma.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Platelet 12-lipoxygenase and stem cells in Barrett's esophagus

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Abstract

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