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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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September-October 2010 Volume 1 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Association of ATP7A expression and in vitro sensitivity to cisplatin in non-small cell lung cancer

  • Authors:
    • Yoshimasa Inoue
    • Hozumi Matsumoto
    • Shunsuke Yamada
    • Kenji Kawai
    • Hiroshi Suemizu
    • Masatoshi Gika
    • Iwao Takanami
    • Masayuki Iwazaki
    • Masato Nakamura
  • View Affiliations / Copyright

    Affiliations: Department of General Thoracic Surgery, Ikegami General Hospital, Ota-ku, Tokyo 146-8531, Japan. yoshimas@is.icc.u-tokai.ac.jp
  • Pages: 837-840
    |
    Published online on: September 1, 2010
       https://doi.org/10.3892/ol_00000147
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Abstract

Expression of copper-transporting P-type adenosine triphosphatase A (ATP7A) is reportedly associated with platinum drug resistance in various types of solid tumors. However, the impact of ATP7A expression on platinum drug resistance in non-small cell lung cancer (NSCLC) has yet to be adequately elucidated. In vitro cisplatin (CDDP) sensitivity was investigated using the collagen gel-droplet embedded culture drug sensitivity test, and the ATP7A mRNA expression levels were assessed by real-time polymerase chain reaction in surgically resected specimens of NSCLC. The relationship between the ATP7A expression levels and the in vitro CDDP sensitivity was then evaluated. The ATP7A mRNA expression levels in the CDDP-resistant tumors were significantly higher than those in the CDDP-sensitive tumors (p=0.0167, Mann-Whitney U test). In conclusion, the results suggest that evaluation of ATP7A expression is useful as a marker for cisplatin chemoresistance.
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1 

Perez RP: Cellular and molecular determinants of cisplatin resistance. Eur J Cancer. 34:1535–1542. 1998. View Article : Google Scholar : PubMed/NCBI

2 

Tiseo M, Franciosi V, Grossi F and Ardizzoni A: Adjuvant chemotherapy for non-small cell lung cancer: ready for clinical practice? Eur J Cancer. 42:8–16. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Terada K, Nakako T, Yang XL, et al: Restoration of holoceruloplasmin synthesis in LEC rat after infusion of recombinant adenovirus bearing WND cDNA. J Biol Chem. 273:1815–1820. 1998. View Article : Google Scholar : PubMed/NCBI

4 

Chelly J, Tumer Z, Tonnesen T, et al: Isolation of a candidate gene for Menkes disease that encodes a potential heavy metal binding protein. Nat Genet. 3:14–19. 1993. View Article : Google Scholar : PubMed/NCBI

5 

Mercer JF, Livingston J, Hall B, et al: Isolation of a partial candidate gene for Menkes disease by positional cloning. Nat Genet. 3:20–25. 1993. View Article : Google Scholar : PubMed/NCBI

6 

Vulpe C, Levinson B, Whitney S, Packman S and Gitschier J: Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting ATPase. Nat Genet. 3:7–13. 1993. View Article : Google Scholar : PubMed/NCBI

7 

Safaei R, Holzer AK, Katano K, Samimi G and Howell SB: The role of copper transporters in the development of resistance to Pt drugs. J Inorg Biochem. 98:1607–1613. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Petris MJ, Strausak D and Mercer JF: The Menkes copper transporter is required for the activation of tyrosinase. Hum Mol Genet. 9:2845–2851. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Samimi G, Varki NM, Wilczynski S, Safaei R, Alberts DS and Howell SB: Increase in expression of the copper transporter ATP7A during platinum drug-based treatment is associated with poor survival in ovarian cancer patients. Clin Cancer Res. 9:5853–5859. 2003.PubMed/NCBI

10 

Samimi G, Safaei R, Katano K, et al: Increased expression of the copper efflux transporter ATP7A mediates resistance to cisplatin, carboplatin, and oxaliplatin in ovarian cancer cells. Clin Cancer Res. 10:4661–4669. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Safaei R, Katano K, Samimi G, et al: Cross-resistance to cisplatin in cells with acquired resistance to copper. Cancer Chemother Pharmacol. 53:239–246. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Kobayashi H, Higashiyama M, Minamigawa K, et al: Examination of in vitro chemosensitivity test using collagen gel droplet culture method with colorimetric endpoint quantification. Jpn J Cancer Res. 92:203–210. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Kobayashi H: Development of a new in vitro chemosensitivity test using collagen gel droplet embedded culture and image analysis for clinical usefulness. Recent Results Cancer Res. 161:48–61. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Kawamura M, Gika M, Abiko T, et al: Clinical evaluation of chemosensitivity testing for patients with unresectable non-small cell lung cancer (NSCLC) using collagen gel droplet embedded culture drug sensitivity test (CD-DST). Cancer Chemother Pharmacol. 59:507–513. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Nakagawa T, Inoue Y, Kodama H, et al: Expression of copper-transporting P-type adenosine triphosphatase (ATP7B) correlates with cisplatin resistance in human non-small cell lung cancer xenografts. Oncol Rep. 20:265–270. 2008.PubMed/NCBI

16 

Nishi M, Abe Y, Fujimori S, et al: The modifier subunit of glutamate cysteine ligase relates to cisplatin resistance in human small-cell lung cancer xenografts in vivo. Oncol Rep. 14:421–424. 2005.PubMed/NCBI

17 

Fujimori S, Abe Y, Nishi M, et al: The subunits of glutamate cysteine ligase enhance cisplatin resistance in human non-small cell lung cancer xenografts in vivo. Int J Oncol. 25:413–418. 2004.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Inoue Y, Matsumoto H, Yamada S, Kawai K, Suemizu H, Gika M, Takanami I, Iwazaki M and Nakamura M: Association of ATP7A expression and in vitro sensitivity to cisplatin in non-small cell lung cancer . Oncol Lett 1: 837-840, 2010.
APA
Inoue, Y., Matsumoto, H., Yamada, S., Kawai, K., Suemizu, H., Gika, M. ... Nakamura, M. (2010). Association of ATP7A expression and in vitro sensitivity to cisplatin in non-small cell lung cancer . Oncology Letters, 1, 837-840. https://doi.org/10.3892/ol_00000147
MLA
Inoue, Y., Matsumoto, H., Yamada, S., Kawai, K., Suemizu, H., Gika, M., Takanami, I., Iwazaki, M., Nakamura, M."Association of ATP7A expression and in vitro sensitivity to cisplatin in non-small cell lung cancer ". Oncology Letters 1.5 (2010): 837-840.
Chicago
Inoue, Y., Matsumoto, H., Yamada, S., Kawai, K., Suemizu, H., Gika, M., Takanami, I., Iwazaki, M., Nakamura, M."Association of ATP7A expression and in vitro sensitivity to cisplatin in non-small cell lung cancer ". Oncology Letters 1, no. 5 (2010): 837-840. https://doi.org/10.3892/ol_00000147
Copy and paste a formatted citation
x
Spandidos Publications style
Inoue Y, Matsumoto H, Yamada S, Kawai K, Suemizu H, Gika M, Takanami I, Iwazaki M and Nakamura M: Association of ATP7A expression and in vitro sensitivity to cisplatin in non-small cell lung cancer . Oncol Lett 1: 837-840, 2010.
APA
Inoue, Y., Matsumoto, H., Yamada, S., Kawai, K., Suemizu, H., Gika, M. ... Nakamura, M. (2010). Association of ATP7A expression and in vitro sensitivity to cisplatin in non-small cell lung cancer . Oncology Letters, 1, 837-840. https://doi.org/10.3892/ol_00000147
MLA
Inoue, Y., Matsumoto, H., Yamada, S., Kawai, K., Suemizu, H., Gika, M., Takanami, I., Iwazaki, M., Nakamura, M."Association of ATP7A expression and in vitro sensitivity to cisplatin in non-small cell lung cancer ". Oncology Letters 1.5 (2010): 837-840.
Chicago
Inoue, Y., Matsumoto, H., Yamada, S., Kawai, K., Suemizu, H., Gika, M., Takanami, I., Iwazaki, M., Nakamura, M."Association of ATP7A expression and in vitro sensitivity to cisplatin in non-small cell lung cancer ". Oncology Letters 1, no. 5 (2010): 837-840. https://doi.org/10.3892/ol_00000147
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