CXCR7 protein expression correlates with elevated mmp-3 secretion in breast cancer cells

Zabel,Brian A.; Miao,Zhenhua; Lai,Nu L.; Wang,Yu; Lewén,Susanna; Berahovich,Robert D.; Jaén,Juan C.; Schall,Thomas J.

doi:10.3892/ol_00000149

September-October 2010 Volume 1 Issue 5

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September-October 2010 Volume 1 Issue 5

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Article

CXCR7 protein expression correlates with elevated mmp-3 secretion in breast cancer cells

Authors:
- Brian A. Zabel
- Zhenhua Miao
- Nu L. Lai
- Yu Wang
- Susanna Lewén
- Robert D. Berahovich
- Juan C. Jaén
- Thomas J. Schall
View Affiliations / Copyright

Affiliations: ChemoCentryx, Inc., Mountain View, CA 94043, USA. bzabel@chemocentryx.com
Pages: 845-847
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Published online on: September 1, 2010

https://doi.org/10.3892/ol_00000149
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Abstract

Metastatic breast cancer is the leading cause of cancer-related death in women worldwide and, despite recent therapeutic advances, the disease remains incurable. A critical step in cancer cell metastasis is the degradation of extracellular matrix components by matrix metalloproteinases (MMPs), which permits malignant cells to separate from the primary tumor and access circulatory conduits for seeding distant organs. This study reports a correlation between the elevated secretion of MMP-3 by breast cancer cells and the expression of CCR7 protein, a recently discovered non-classical chemokine receptor that may play a role in metastasis by regulating tumor cell transendothelial migration. MMP-3 secretion is increased in human mammary tumor cells that overexpress CXCR7, and is reduced in mouse breast cancer cells in which the endogenous CXCR7 expression has been knocked down via RNAi. The correlation between CXCR7 and MMP-3 expression in breast cancer may provide additional therapeutic rationale for targeting CXCR7 in order to prevent metastatic disease.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

CXCR7 protein expression correlates with elevated mmp-3 secretion in breast cancer cells

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