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Article

Addition of transcatheter arterial chemoembolization decreased local recurrence but had no survival benefit to percutaneous ethanol injection therapy for patients with small hepatocellular carcinoma: A multicenter randomized control study

  • Authors:
    • Akira Mizuki
    • Masayuki Tatemichi
    • Nobuhiro Tsukada
    • Ryousuke Nagamatsu
    • Mitsuhiko Kawagushi
    • Tatsuya Itoshima
    • Shigeki Maruyama
    • Atsuhiko Satou
    • Yasuhisa Imari
    • Toshiharu Kawatoko
    • Junya Shimono
    • Hiroshi Nagata
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Saiseikai Central Hospital, Tokyo, Japan. amizuki@highway.ne.jp
  • Pages: 855-859
    |
    Published online on: September 1, 2010
       https://doi.org/10.3892/ol_00000151
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Abstract

To assess the efficacy of the additional treatment of transcatheter arterial chemoembolization (TACE) to percutaneous ethanol injection (PEI) therapy for relatively small hepatocellular carcinomas (HCCs), a multicenter randomized control study (RCT) was performed. We conducted an RCT and follow-up study during the enrollment period from 1997 to 1999. Newly diagnosed patients with one to three HCC tumors measuring from 2 to 4 cm (4 cm maximum) in diameter were enrolled. A total of 30 patients initially underwent a combination TACE-PEI or PEI-alone therapies at eight randomly assigned Japanese hospitals. However, 3 patients withdrew. Of the 27 remaining patients, 13 were treated with the combination TACE-PEI therapy and 14 with PEI therapy alone. The patients were observed over several months [median (interquartile range) 33.2 (24.6) months]. There were no significant differences in the background of the patients between the two groups. Among the patients treated with TACE-PEI, the development of a local residual tumor was of significantly lower occurence, compared to the group receiving PEI alone (7.6 and 42.9%, respectively; P=0.024). However, the mean cancer-free time (absence of local or multiple nodule recurrence) or patient survival time was not significantly different between the two groups [PEI alone vs. TACE-PEI: cancer-free time 16.7 (95% CI 7.3-26.0) vs. 22.9 months (95% CI 12.4-33.4); survival time 57.2 (95% CI 37.2-77.2) vs. 42.4 months (95% CI 29.2-55.6)]. Although the combination of TACE and PEI had significant effects on the local tumor control, no efficacy of the addition of TACE to PEI was noted in the prognosis among patients with relatively small HCC tumors.
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Copy and paste a formatted citation
Spandidos Publications style
Mizuki A, Tatemichi M, Tsukada N, Nagamatsu R, Kawagushi M, Itoshima T, Maruyama S, Satou A, Imari Y, Kawatoko T, Kawatoko T, et al: Addition of transcatheter arterial chemoembolization decreased local recurrence but had no survival benefit to percutaneous ethanol injection therapy for patients with small hepatocellular carcinoma: A multicenter randomized control study . Oncol Lett 1: 855-859, 2010.
APA
Mizuki, A., Tatemichi, M., Tsukada, N., Nagamatsu, R., Kawagushi, M., Itoshima, T. ... Nagata, H. (2010). Addition of transcatheter arterial chemoembolization decreased local recurrence but had no survival benefit to percutaneous ethanol injection therapy for patients with small hepatocellular carcinoma: A multicenter randomized control study . Oncology Letters, 1, 855-859. https://doi.org/10.3892/ol_00000151
MLA
Mizuki, A., Tatemichi, M., Tsukada, N., Nagamatsu, R., Kawagushi, M., Itoshima, T., Maruyama, S., Satou, A., Imari, Y., Kawatoko, T., Shimono, J., Nagata, H."Addition of transcatheter arterial chemoembolization decreased local recurrence but had no survival benefit to percutaneous ethanol injection therapy for patients with small hepatocellular carcinoma: A multicenter randomized control study ". Oncology Letters 1.5 (2010): 855-859.
Chicago
Mizuki, A., Tatemichi, M., Tsukada, N., Nagamatsu, R., Kawagushi, M., Itoshima, T., Maruyama, S., Satou, A., Imari, Y., Kawatoko, T., Shimono, J., Nagata, H."Addition of transcatheter arterial chemoembolization decreased local recurrence but had no survival benefit to percutaneous ethanol injection therapy for patients with small hepatocellular carcinoma: A multicenter randomized control study ". Oncology Letters 1, no. 5 (2010): 855-859. https://doi.org/10.3892/ol_00000151
Copy and paste a formatted citation
x
Spandidos Publications style
Mizuki A, Tatemichi M, Tsukada N, Nagamatsu R, Kawagushi M, Itoshima T, Maruyama S, Satou A, Imari Y, Kawatoko T, Kawatoko T, et al: Addition of transcatheter arterial chemoembolization decreased local recurrence but had no survival benefit to percutaneous ethanol injection therapy for patients with small hepatocellular carcinoma: A multicenter randomized control study . Oncol Lett 1: 855-859, 2010.
APA
Mizuki, A., Tatemichi, M., Tsukada, N., Nagamatsu, R., Kawagushi, M., Itoshima, T. ... Nagata, H. (2010). Addition of transcatheter arterial chemoembolization decreased local recurrence but had no survival benefit to percutaneous ethanol injection therapy for patients with small hepatocellular carcinoma: A multicenter randomized control study . Oncology Letters, 1, 855-859. https://doi.org/10.3892/ol_00000151
MLA
Mizuki, A., Tatemichi, M., Tsukada, N., Nagamatsu, R., Kawagushi, M., Itoshima, T., Maruyama, S., Satou, A., Imari, Y., Kawatoko, T., Shimono, J., Nagata, H."Addition of transcatheter arterial chemoembolization decreased local recurrence but had no survival benefit to percutaneous ethanol injection therapy for patients with small hepatocellular carcinoma: A multicenter randomized control study ". Oncology Letters 1.5 (2010): 855-859.
Chicago
Mizuki, A., Tatemichi, M., Tsukada, N., Nagamatsu, R., Kawagushi, M., Itoshima, T., Maruyama, S., Satou, A., Imari, Y., Kawatoko, T., Shimono, J., Nagata, H."Addition of transcatheter arterial chemoembolization decreased local recurrence but had no survival benefit to percutaneous ethanol injection therapy for patients with small hepatocellular carcinoma: A multicenter randomized control study ". Oncology Letters 1, no. 5 (2010): 855-859. https://doi.org/10.3892/ol_00000151
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