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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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September-October 2010 Volume 1 Issue 5

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Value of napsin A and thyroid transcription factor-1 in the identification of primary lung adenocarcinoma

  • Authors:
    • Peng Zhang
    • Yi-Ping Han
    • Ling Huang
    • Qiang Li
    • Da-Lie Ma
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Changhai Hospital, Shanghai 200433, P.R. China
  • Pages: 899-903
    |
    Published online on: September 1, 2010
       https://doi.org/10.3892/ol_00000160
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Abstract

Napsin A is a newly discovered functional aspartic proteinase that is expressed in normal lung parenchyma in type II pneumocytes and is thought to be associated with primary lung adenocarcinoma. Thyroid transcription factor-1 (TTF-1) is a widely used relatively restricted marker for lung adenocarcinoma. The present study aimed to compare the usefulness of napsin A with TTF-1 for the identification of primary lung adenocarcinoma. Immunohistochemical expression of napsin A and TTF-1 was analyzed in 351 lung cancer tissues, including 27 metastases. Napsin A was expressed in 180 of 212 (84.9%) primary lung adenocarcinomas, while no expression was noted in all 27 metastatic lung cancer specimens, including 19 metastatic adenocarcinomas. In contrast, TTF-1 expression was not only noted in 179 of 212 (84.4%) primary lung adenocarcinomas, but also in 12 of 18 (66.7%) small-cell carcinomas and some of the squamous carcinomas, as well as in one metastatic adenocarcinoma from the thyroid. The sensitivity and specificity of napsin A for primary lung adenocarcinoma (84.9 and 93.8%, respectively) were higher than the sensitivity and specificity of TTF-1 (84.4 and 83.9%, respectively). By combining napsin A and TTF-1, sensitivity increased to 91.0%. Furthermore, the sensitivity and specificity expression was associated with gender, smoking history, performance status, pathological type, primary tumor size and nodal metastasis. Therefore, napsin A is a useful novel marker in the differential diagnosis of primary lung adenocarcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang P, Han Y, Huang L, Li Q and Ma D: Value of napsin A and thyroid transcription factor-1 in the identification of primary lung adenocarcinoma . Oncol Lett 1: 899-903, 2010.
APA
Zhang, P., Han, Y., Huang, L., Li, Q., & Ma, D. (2010). Value of napsin A and thyroid transcription factor-1 in the identification of primary lung adenocarcinoma . Oncology Letters, 1, 899-903. https://doi.org/10.3892/ol_00000160
MLA
Zhang, P., Han, Y., Huang, L., Li, Q., Ma, D."Value of napsin A and thyroid transcription factor-1 in the identification of primary lung adenocarcinoma ". Oncology Letters 1.5 (2010): 899-903.
Chicago
Zhang, P., Han, Y., Huang, L., Li, Q., Ma, D."Value of napsin A and thyroid transcription factor-1 in the identification of primary lung adenocarcinoma ". Oncology Letters 1, no. 5 (2010): 899-903. https://doi.org/10.3892/ol_00000160
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang P, Han Y, Huang L, Li Q and Ma D: Value of napsin A and thyroid transcription factor-1 in the identification of primary lung adenocarcinoma . Oncol Lett 1: 899-903, 2010.
APA
Zhang, P., Han, Y., Huang, L., Li, Q., & Ma, D. (2010). Value of napsin A and thyroid transcription factor-1 in the identification of primary lung adenocarcinoma . Oncology Letters, 1, 899-903. https://doi.org/10.3892/ol_00000160
MLA
Zhang, P., Han, Y., Huang, L., Li, Q., Ma, D."Value of napsin A and thyroid transcription factor-1 in the identification of primary lung adenocarcinoma ". Oncology Letters 1.5 (2010): 899-903.
Chicago
Zhang, P., Han, Y., Huang, L., Li, Q., Ma, D."Value of napsin A and thyroid transcription factor-1 in the identification of primary lung adenocarcinoma ". Oncology Letters 1, no. 5 (2010): 899-903. https://doi.org/10.3892/ol_00000160
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