COMBINATIVE GROWTH-INHIBITORY EFFECTS OF INTERFERON-ALPHA AND DOXORUBICIN ON MULTIDRUG-RESISTANT TUMOR-CELL LINES
- V LEONARDI
- N BORSELLINO
- M CRESCIMANNO
- C FLANDINA
- A FLUGY
- N DALESSANDRO
Affiliations: UNIV PALERMO,POLICLIN PAOLO GIACCONE,INST PHARMACOL,I-90127 PALERMO,ITALY.
- Published online on: January 1, 1994 https://doi.org/10.3892/or.1.1.161
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The antiproliferative effects of interferon-alpha (IFN-alpha) and of its combination with doxorubicin (DXR) were studied on three tumor cell lines, the mouse B16 melanoma and Friend erythroleukemia and the human K562 erythroleukemia, both as DXR-sensitive (B16, FLC, K562) and resistant (B16-DXR, FLC-DXR, K562-DXR) variants; the latter lines were endowed with typical multidrug resistance (MDR). Growth inhibition by IFN-alpha was greater in B16-DXR and FLC-DXR than in their chemosensitive counterparts and was superimposable in K562 and K562-DXR. On the other hand, the combination of IFN-alpha and DXR turned out to be merely additive in B16, B16-DXR, K562 and K562-DXR; it was synergistic in FLC and antagonistic in FLC-DXR. Our results and those of others seem to indicate that synergy between IFN-alpha and DXR may occur rarely in MDR cells.