COMBINATIVE GROWTH-INHIBITORY EFFECTS OF INTERFERON-ALPHA AND DOXORUBICIN ON MULTIDRUG-RESISTANT TUMOR-CELL LINES

  • Authors:
    • V LEONARDI
    • N BORSELLINO
    • M CRESCIMANNO
    • C FLANDINA
    • A FLUGY
    • N DALESSANDRO
  • View Affiliations

  • Published online on: January 1, 1994     https://doi.org/10.3892/or.1.1.161
  • Pages: 161-164
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Abstract

The antiproliferative effects of interferon-alpha (IFN-alpha) and of its combination with doxorubicin (DXR) were studied on three tumor cell lines, the mouse B16 melanoma and Friend erythroleukemia and the human K562 erythroleukemia, both as DXR-sensitive (B16, FLC, K562) and resistant (B16-DXR, FLC-DXR, K562-DXR) variants; the latter lines were endowed with typical multidrug resistance (MDR). Growth inhibition by IFN-alpha was greater in B16-DXR and FLC-DXR than in their chemosensitive counterparts and was superimposable in K562 and K562-DXR. On the other hand, the combination of IFN-alpha and DXR turned out to be merely additive in B16, B16-DXR, K562 and K562-DXR; it was synergistic in FLC and antagonistic in FLC-DXR. Our results and those of others seem to indicate that synergy between IFN-alpha and DXR may occur rarely in MDR cells.

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January 1994
Volume 1 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
LEONARDI V, BORSELLINO N, CRESCIMANNO M, FLANDINA C, FLUGY A and DALESSANDRO N: COMBINATIVE GROWTH-INHIBITORY EFFECTS OF INTERFERON-ALPHA AND DOXORUBICIN ON MULTIDRUG-RESISTANT TUMOR-CELL LINES. Oncol Rep 1: 161-164, 1994.
APA
LEONARDI, V., BORSELLINO, N., CRESCIMANNO, M., FLANDINA, C., FLUGY, A., & DALESSANDRO, N. (1994). COMBINATIVE GROWTH-INHIBITORY EFFECTS OF INTERFERON-ALPHA AND DOXORUBICIN ON MULTIDRUG-RESISTANT TUMOR-CELL LINES. Oncology Reports, 1, 161-164. https://doi.org/10.3892/or.1.1.161
MLA
LEONARDI, V., BORSELLINO, N., CRESCIMANNO, M., FLANDINA, C., FLUGY, A., DALESSANDRO, N."COMBINATIVE GROWTH-INHIBITORY EFFECTS OF INTERFERON-ALPHA AND DOXORUBICIN ON MULTIDRUG-RESISTANT TUMOR-CELL LINES". Oncology Reports 1.1 (1994): 161-164.
Chicago
LEONARDI, V., BORSELLINO, N., CRESCIMANNO, M., FLANDINA, C., FLUGY, A., DALESSANDRO, N."COMBINATIVE GROWTH-INHIBITORY EFFECTS OF INTERFERON-ALPHA AND DOXORUBICIN ON MULTIDRUG-RESISTANT TUMOR-CELL LINES". Oncology Reports 1, no. 1 (1994): 161-164. https://doi.org/10.3892/or.1.1.161