COMPARISON OF GENIPOSIDE AND ITS ACETYLATED DERIVATIVE FOR THE INHIBITION OF AFLATOXIN B1-INDUCED DNA-REPAIR SYNTHESIS IN RAT PRIMARY HEPATOCYTE

  • Authors:
    • TH TSENG
    • CY CHU
    • CJ WANG
  • View Affiliations

  • Published online on: January 1, 1994     https://doi.org/10.3892/or.1.1.165
  • Pages: 165-168
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Our previous studies showed that geniposide (GP) inhibits aflatoxin B1 (AFB1)-induced hepatoxicity in rats, and that DNA repair synthesis in vitro and penta-acetyl geniposide ((Ac)5-GP) inhibits AFB1-induced genotoxicity in C3H10T1/2 cells. One possible mechanism for GP is the enhancement of the enzyme activity of glutathione S-transferase (GST) and GSH-peroxidase (GSH-Px) in AFB1-treated hepatocyte culture. But the mechanism is unknown for (Ac)5-GP. The present study demonstrated that (Ac)5-GP was more potent in inhibiting AFB1-induced unscheduled DNA synthesis in rat primary hepatocyte. The action of GP and (Ac)S-GP may be related to their ability to induce the activity of phase II enzymes.

Related Articles

Journal Cover

January 1994
Volume 1 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
TSENG T, CHU C and WANG C: COMPARISON OF GENIPOSIDE AND ITS ACETYLATED DERIVATIVE FOR THE INHIBITION OF AFLATOXIN B1-INDUCED DNA-REPAIR SYNTHESIS IN RAT PRIMARY HEPATOCYTE. Oncol Rep 1: 165-168, 1994
APA
TSENG, T., CHU, C., & WANG, C. (1994). COMPARISON OF GENIPOSIDE AND ITS ACETYLATED DERIVATIVE FOR THE INHIBITION OF AFLATOXIN B1-INDUCED DNA-REPAIR SYNTHESIS IN RAT PRIMARY HEPATOCYTE. Oncology Reports, 1, 165-168. https://doi.org/10.3892/or.1.1.165
MLA
TSENG, T., CHU, C., WANG, C."COMPARISON OF GENIPOSIDE AND ITS ACETYLATED DERIVATIVE FOR THE INHIBITION OF AFLATOXIN B1-INDUCED DNA-REPAIR SYNTHESIS IN RAT PRIMARY HEPATOCYTE". Oncology Reports 1.1 (1994): 165-168.
Chicago
TSENG, T., CHU, C., WANG, C."COMPARISON OF GENIPOSIDE AND ITS ACETYLATED DERIVATIVE FOR THE INHIBITION OF AFLATOXIN B1-INDUCED DNA-REPAIR SYNTHESIS IN RAT PRIMARY HEPATOCYTE". Oncology Reports 1, no. 1 (1994): 165-168. https://doi.org/10.3892/or.1.1.165