CARBOPLATIN ASSOCIATED ANEMIA TREATED WITH SUBCUTANEOUS ERYTHROPOIETIN - A PILOT-STUDY

  • Authors:
    • S CASCINU
    • A FEDELI
    • E DELFERRO
    • SL FEDELI
    • G CATALANO
  • View Affiliations

  • Published online on: January 1, 1994     https://doi.org/10.3892/or.1.1.169
  • Pages: 169-172
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Abstract

In nineteen patients with carboplatin-induced anemia (hemoglobin less than 90 g/l), recombinant human erythropoietin was administered subcutaneously three times a week on an outpatient basis. The initial dose was 50 Units/kg of body weight. If response was not achieved within 3 weeks, dose was increased to 75 Units/kg. Using the same criteria further escalations to 100 and 150 Units/kg were performed. If there was no response erythropoietin was terminated. Two patients obtained an increase of hemoglobin levels greater than 100 g/l, which was considered as a clinical response in this study, with a dose of 75 U/kg; eleven patients needed an erythropoietin dose of 100 U/kg and three a dose of 150 U/kg. The other three patients required hemotransfusions and were considered non responders. Hemoglobin increases occurred despite continuation of carboplatin chemotherapy. In conclusion, subcutaneous eryhtropoietin is effective and safe in the treatment of carboplatin-induced anemia.

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January 1994
Volume 1 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
CASCINU S, FEDELI A, DELFERRO E, FEDELI S and CATALANO G: CARBOPLATIN ASSOCIATED ANEMIA TREATED WITH SUBCUTANEOUS ERYTHROPOIETIN - A PILOT-STUDY. Oncol Rep 1: 169-172, 1994
APA
CASCINU, S., FEDELI, A., DELFERRO, E., FEDELI, S., & CATALANO, G. (1994). CARBOPLATIN ASSOCIATED ANEMIA TREATED WITH SUBCUTANEOUS ERYTHROPOIETIN - A PILOT-STUDY. Oncology Reports, 1, 169-172. https://doi.org/10.3892/or.1.1.169
MLA
CASCINU, S., FEDELI, A., DELFERRO, E., FEDELI, S., CATALANO, G."CARBOPLATIN ASSOCIATED ANEMIA TREATED WITH SUBCUTANEOUS ERYTHROPOIETIN - A PILOT-STUDY". Oncology Reports 1.1 (1994): 169-172.
Chicago
CASCINU, S., FEDELI, A., DELFERRO, E., FEDELI, S., CATALANO, G."CARBOPLATIN ASSOCIATED ANEMIA TREATED WITH SUBCUTANEOUS ERYTHROPOIETIN - A PILOT-STUDY". Oncology Reports 1, no. 1 (1994): 169-172. https://doi.org/10.3892/or.1.1.169