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THE ADDITION OF MESNA TO HYPERHYDRATION DOES NOT DECREASE THE INCIDENCE OF HEMORRHAGIC CYSTITIS IN PATIENTS RECEIVING HIGH-DOSE CYCLOPHOSPHAMIDE

  • Authors:
    • CP MURPHY
    • EA HARDEN
    • DA STEVENS
    • JP LYNCH
    • V MONTES
    • RH HERZIG

  • View Affiliations

  • Published online on: January 1, 1994     https://doi.org/10.3892/or.1.1.265
  • Pages: 265-266
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

To assess the efficacy of hyperhydration Versus hyperhydration plus mesna in preventing cyclophosphamide induced hemorrhagic cystitis a retrospective analysis was conducted of 110 patients who received hyperhydration alone (baseline intravenous intake of at least 3.6 1/m(2)/day) and 107 patients who received hyperhydration plus mesna (120% of daily cyclophosphamide dose) while receiving cyclophosphamide (total dose 150-200 mg/kg) as part of a dose intensive regimen. Macroscopic hematuria was noted in 17 (16%) and 9 (8%) patients who received hyperhydration with or without mesna, respectively (p=0.08). This analysis failed to demonstrate a benefit in adding mesna to hyperhydration alone in preventing cyclophosphamide induced hemorrhagic cystitis.

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January 1994
Volume 1 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
MURPHY C, HARDEN E, STEVENS D, LYNCH J, MONTES V and HERZIG R: THE ADDITION OF MESNA TO HYPERHYDRATION DOES NOT DECREASE THE INCIDENCE OF HEMORRHAGIC CYSTITIS IN PATIENTS RECEIVING HIGH-DOSE CYCLOPHOSPHAMIDE. Oncol Rep 1: 265-266, 1994
APA
MURPHY, C., HARDEN, E., STEVENS, D., LYNCH, J., MONTES, V., & HERZIG, R. (1994). THE ADDITION OF MESNA TO HYPERHYDRATION DOES NOT DECREASE THE INCIDENCE OF HEMORRHAGIC CYSTITIS IN PATIENTS RECEIVING HIGH-DOSE CYCLOPHOSPHAMIDE. Oncology Reports, 1, 265-266. https://doi.org/10.3892/or.1.1.265
MLA
MURPHY, C., HARDEN, E., STEVENS, D., LYNCH, J., MONTES, V., HERZIG, R."THE ADDITION OF MESNA TO HYPERHYDRATION DOES NOT DECREASE THE INCIDENCE OF HEMORRHAGIC CYSTITIS IN PATIENTS RECEIVING HIGH-DOSE CYCLOPHOSPHAMIDE". Oncology Reports 1.1 (1994): 265-266.
Chicago
MURPHY, C., HARDEN, E., STEVENS, D., LYNCH, J., MONTES, V., HERZIG, R."THE ADDITION OF MESNA TO HYPERHYDRATION DOES NOT DECREASE THE INCIDENCE OF HEMORRHAGIC CYSTITIS IN PATIENTS RECEIVING HIGH-DOSE CYCLOPHOSPHAMIDE". Oncology Reports 1, no. 1 (1994): 265-266. https://doi.org/10.3892/or.1.1.265