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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 1994 Volume 1 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 1994 Volume 1 Issue 1

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Article

THE MICROFOCUS ASSAY SYSTEM (MFAS) - A SIMPLE QUANTITATIVE ASSAY TO IDENTIFY INHIBITORY DRUGS TARGETED AGAINST SPECIFIC ONCOGENES

  • Authors:
    • DB REARDON
    • YM XIE
    • MC HUNG

  • View Affiliations / Copyright

    Affiliations: UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT TUMOR BIOL,HOUSTON,TX 77030. UNIV TEXAS,HLTH SCI CTR,GRAD SCH BIOMED SCI,HOUSTON,TX 77030.
  • Pages: 37-41
    |
    Published online on: January 1, 1994
       https://doi.org/10.3892/or.1.1.37
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Abstract

We have developed an assay, the microfocus assay system (MFAS), that enables the quantitative assessment of anticancer drugs and their ability to specifically target and inhibit cellular oncogenes. Analysis of three chemotherapeutic reagents showed a differential negative effect against the ability of transformed cells containing either the oncogenic rat neu, human H-ras, or v-mos oncogene to form transformed foci on a background of normal fibroblasts. Though these drugs have not been examined previously for targeting against specific oncogenes, our results with the MFAS indicate preferential inhibitory effects against cells transformed with different oncogenes. Therefore, the MFAS should enable the large scale screening of anti-cancer drugs specifically targeted against known oncogenes and provide a quantitative measurement of their effectiveness.

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Copy and paste a formatted citation
Spandidos Publications style
REARDON D, XIE Y and HUNG M: THE MICROFOCUS ASSAY SYSTEM (MFAS) - A SIMPLE QUANTITATIVE ASSAY TO IDENTIFY INHIBITORY DRUGS TARGETED AGAINST SPECIFIC ONCOGENES. Oncol Rep 1: 37-41, 1994.
APA
REARDON, D., XIE, Y., & HUNG, M. (1994). THE MICROFOCUS ASSAY SYSTEM (MFAS) - A SIMPLE QUANTITATIVE ASSAY TO IDENTIFY INHIBITORY DRUGS TARGETED AGAINST SPECIFIC ONCOGENES. Oncology Reports, 1, 37-41. https://doi.org/10.3892/or.1.1.37
MLA
REARDON, D., XIE, Y., HUNG, M."THE MICROFOCUS ASSAY SYSTEM (MFAS) - A SIMPLE QUANTITATIVE ASSAY TO IDENTIFY INHIBITORY DRUGS TARGETED AGAINST SPECIFIC ONCOGENES". Oncology Reports 1.1 (1994): 37-41.
Chicago
REARDON, D., XIE, Y., HUNG, M."THE MICROFOCUS ASSAY SYSTEM (MFAS) - A SIMPLE QUANTITATIVE ASSAY TO IDENTIFY INHIBITORY DRUGS TARGETED AGAINST SPECIFIC ONCOGENES". Oncology Reports 1, no. 1 (1994): 37-41. https://doi.org/10.3892/or.1.1.37
Copy and paste a formatted citation
x
Spandidos Publications style
REARDON D, XIE Y and HUNG M: THE MICROFOCUS ASSAY SYSTEM (MFAS) - A SIMPLE QUANTITATIVE ASSAY TO IDENTIFY INHIBITORY DRUGS TARGETED AGAINST SPECIFIC ONCOGENES. Oncol Rep 1: 37-41, 1994.
APA
REARDON, D., XIE, Y., & HUNG, M. (1994). THE MICROFOCUS ASSAY SYSTEM (MFAS) - A SIMPLE QUANTITATIVE ASSAY TO IDENTIFY INHIBITORY DRUGS TARGETED AGAINST SPECIFIC ONCOGENES. Oncology Reports, 1, 37-41. https://doi.org/10.3892/or.1.1.37
MLA
REARDON, D., XIE, Y., HUNG, M."THE MICROFOCUS ASSAY SYSTEM (MFAS) - A SIMPLE QUANTITATIVE ASSAY TO IDENTIFY INHIBITORY DRUGS TARGETED AGAINST SPECIFIC ONCOGENES". Oncology Reports 1.1 (1994): 37-41.
Chicago
REARDON, D., XIE, Y., HUNG, M."THE MICROFOCUS ASSAY SYSTEM (MFAS) - A SIMPLE QUANTITATIVE ASSAY TO IDENTIFY INHIBITORY DRUGS TARGETED AGAINST SPECIFIC ONCOGENES". Oncology Reports 1, no. 1 (1994): 37-41. https://doi.org/10.3892/or.1.1.37
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