C-JUN ONCOGENE EXPRESSION IN NONSMALL CELL LUNG-CANCER

  • Authors:
    • H KOUTSELINI
    • A MALLIRI
    • E PAPADAKIS
    • DAF GILLESPIE
    • DA SPANDIDOS
  • View Affiliations

  • Published online on: March 1, 1994     https://doi.org/10.3892/or.1.2.353
  • Pages: 353-356
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Primary lung cancer specimens of the non-small cell (NSC) types were examined for expression of the c-jun gene at the protein level by immunocytochemistry using the polyclonal antibody c-jun 890. The results obtained revealed that the c-jun p39 protein was expressed in 82% (18/22) of squamous cell carcinomas, 77% (10/15) of adenocarcinomas and 40% (2/5) of large cell anaplastic carcinomas, but no staining was seen in the non-cancer cases. Positive immunostaining was also seen in 16.7% (3/18) of the nonneoplastic bronchial cells of positively stained squamous cell carcinomas and in 40% (4/10) of adenocarcinomas. We suggest that elevated expression df c-jun p39 protein which was seen in a total of 75% (30/40) of the NSCLC, plays a role in lung cancer.

Related Articles

Journal Cover

March 1994
Volume 1 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
KOUTSELINI H, MALLIRI A, PAPADAKIS E, GILLESPIE D and SPANDIDOS D: C-JUN ONCOGENE EXPRESSION IN NONSMALL CELL LUNG-CANCER. Oncol Rep 1: 353-356, 1994
APA
KOUTSELINI, H., MALLIRI, A., PAPADAKIS, E., GILLESPIE, D., & SPANDIDOS, D. (1994). C-JUN ONCOGENE EXPRESSION IN NONSMALL CELL LUNG-CANCER. Oncology Reports, 1, 353-356. https://doi.org/10.3892/or.1.2.353
MLA
KOUTSELINI, H., MALLIRI, A., PAPADAKIS, E., GILLESPIE, D., SPANDIDOS, D."C-JUN ONCOGENE EXPRESSION IN NONSMALL CELL LUNG-CANCER". Oncology Reports 1.2 (1994): 353-356.
Chicago
KOUTSELINI, H., MALLIRI, A., PAPADAKIS, E., GILLESPIE, D., SPANDIDOS, D."C-JUN ONCOGENE EXPRESSION IN NONSMALL CELL LUNG-CANCER". Oncology Reports 1, no. 2 (1994): 353-356. https://doi.org/10.3892/or.1.2.353