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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 1994 Volume 1 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 1994 Volume 1 Issue 2

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HUMAN LUNG, BLADDER AND HEAD AND NECK TUMORS AS COMPARED TO THEIR ADJACENT NORMAL-TISSUES HAVE ELEVATED AP-1 ACTIVITY AND RECOGNIZE SEQUENCE ELEMENTS OF HIV-1 LTR

  • Authors:
    • V ZOUMPOURLIS
    • E PAPADAKIS
    • D DELAKAS
    • A CRANIDIS
    • J SEGAS
    • H PAPADAKIS
    • DA SPANDIDOS
  • View Affiliations / Copyright

    Affiliations: NATL HELLEN RES FND,INST BIOL RES & BIOTECHNOL,GR-11635 ATHENS,GREECE. UNIV CRETE,SCH MED,IRAKLION,GREECE. METAXA ANTICANC HOSP,PIRAEUS,GREECE.
  • Pages: 403-409
    |
    Published online on: March 1, 1994
       https://doi.org/10.3892/or.1.2.403
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Abstract

We have previously reported the specific binding of nuclear factor AP-1 isolated from human breast MDA MB 468 and HeLa cervical tumor cell lines to oligonucleotides complementary to three newly elucidated sequences within the HIV-1 LTR. These synthesized oligonucleotides, which bear high homology to the AP-1 recognition sequence, were used in the present study in gel retardation assays together with unfractionated nuclear protein extracts from human lung, bladder and head and neck tumors and adjacent normal tissue to study the role of the AP-1 protein in the regulation of HIV-1 expression. We found increased binding of AP-1 to these oligonucleotides in 9/12 lung tumors, 9/14 bladder tumors and 7/7 head and neck tumors as compared to adjacent normal tissues. This confirms previous results obtained when using MDA MB 468 and HeLa nuclear protein extracts. These results indicate that, AP-1 could be contributing to the HIV-1 transcriptional regulation through its interaction with the AP-I binding sites of HIV-I LTR.

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Copy and paste a formatted citation
Spandidos Publications style
ZOUMPOURLIS V, PAPADAKIS E, DELAKAS D, CRANIDIS A, SEGAS J, PAPADAKIS H and SPANDIDOS D: HUMAN LUNG, BLADDER AND HEAD AND NECK TUMORS AS COMPARED TO THEIR ADJACENT NORMAL-TISSUES HAVE ELEVATED AP-1 ACTIVITY AND RECOGNIZE SEQUENCE ELEMENTS OF HIV-1 LTR. Oncol Rep 1: 403-409, 1994.
APA
ZOUMPOURLIS, V., PAPADAKIS, E., DELAKAS, D., CRANIDIS, A., SEGAS, J., PAPADAKIS, H., & SPANDIDOS, D. (1994). HUMAN LUNG, BLADDER AND HEAD AND NECK TUMORS AS COMPARED TO THEIR ADJACENT NORMAL-TISSUES HAVE ELEVATED AP-1 ACTIVITY AND RECOGNIZE SEQUENCE ELEMENTS OF HIV-1 LTR. Oncology Reports, 1, 403-409. https://doi.org/10.3892/or.1.2.403
MLA
ZOUMPOURLIS, V., PAPADAKIS, E., DELAKAS, D., CRANIDIS, A., SEGAS, J., PAPADAKIS, H., SPANDIDOS, D."HUMAN LUNG, BLADDER AND HEAD AND NECK TUMORS AS COMPARED TO THEIR ADJACENT NORMAL-TISSUES HAVE ELEVATED AP-1 ACTIVITY AND RECOGNIZE SEQUENCE ELEMENTS OF HIV-1 LTR". Oncology Reports 1.2 (1994): 403-409.
Chicago
ZOUMPOURLIS, V., PAPADAKIS, E., DELAKAS, D., CRANIDIS, A., SEGAS, J., PAPADAKIS, H., SPANDIDOS, D."HUMAN LUNG, BLADDER AND HEAD AND NECK TUMORS AS COMPARED TO THEIR ADJACENT NORMAL-TISSUES HAVE ELEVATED AP-1 ACTIVITY AND RECOGNIZE SEQUENCE ELEMENTS OF HIV-1 LTR". Oncology Reports 1, no. 2 (1994): 403-409. https://doi.org/10.3892/or.1.2.403
Copy and paste a formatted citation
x
Spandidos Publications style
ZOUMPOURLIS V, PAPADAKIS E, DELAKAS D, CRANIDIS A, SEGAS J, PAPADAKIS H and SPANDIDOS D: HUMAN LUNG, BLADDER AND HEAD AND NECK TUMORS AS COMPARED TO THEIR ADJACENT NORMAL-TISSUES HAVE ELEVATED AP-1 ACTIVITY AND RECOGNIZE SEQUENCE ELEMENTS OF HIV-1 LTR. Oncol Rep 1: 403-409, 1994.
APA
ZOUMPOURLIS, V., PAPADAKIS, E., DELAKAS, D., CRANIDIS, A., SEGAS, J., PAPADAKIS, H., & SPANDIDOS, D. (1994). HUMAN LUNG, BLADDER AND HEAD AND NECK TUMORS AS COMPARED TO THEIR ADJACENT NORMAL-TISSUES HAVE ELEVATED AP-1 ACTIVITY AND RECOGNIZE SEQUENCE ELEMENTS OF HIV-1 LTR. Oncology Reports, 1, 403-409. https://doi.org/10.3892/or.1.2.403
MLA
ZOUMPOURLIS, V., PAPADAKIS, E., DELAKAS, D., CRANIDIS, A., SEGAS, J., PAPADAKIS, H., SPANDIDOS, D."HUMAN LUNG, BLADDER AND HEAD AND NECK TUMORS AS COMPARED TO THEIR ADJACENT NORMAL-TISSUES HAVE ELEVATED AP-1 ACTIVITY AND RECOGNIZE SEQUENCE ELEMENTS OF HIV-1 LTR". Oncology Reports 1.2 (1994): 403-409.
Chicago
ZOUMPOURLIS, V., PAPADAKIS, E., DELAKAS, D., CRANIDIS, A., SEGAS, J., PAPADAKIS, H., SPANDIDOS, D."HUMAN LUNG, BLADDER AND HEAD AND NECK TUMORS AS COMPARED TO THEIR ADJACENT NORMAL-TISSUES HAVE ELEVATED AP-1 ACTIVITY AND RECOGNIZE SEQUENCE ELEMENTS OF HIV-1 LTR". Oncology Reports 1, no. 2 (1994): 403-409. https://doi.org/10.3892/or.1.2.403
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