EXPRESSION OF NK-ASSOCIATED SURFACE-ANTIGENS CD-56 AND CD-16 ON AML-CELLS

  • Authors:
    • W ZELLER
    • B SCHAFER
    • A BENZ
    • K GUTENSOHN
    • K BECKER
    • W FIEDLER
    • DK HOSSFELD
  • View Affiliations

  • Published online on: March 1, 1994     https://doi.org/10.3892/or.1.2.411
  • Pages: 411-414
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Abstract

Monoclonal antibodies Leu 11a (CD16) and Leu 19 (CD56) were tested for reactivity with cells from 36 patients with acute myelogenous leukemia (AML) using two-colour flow cytometry. Blast cells were identified by a broad panel of monoclonal antibodies. In 33% (12/36) the monoclonal antibody Leu 19, which has been demonstrated to bind to the 140 kD isoform of the human neural cellular adhesion molecule N-CAM, found on peripheral natural killer (NK)-cells, neuroectodermal cells, activated T-cells, and myeloma cells, was shown to bind strongly to the leukemic cells. The monoclonal antibody Leu 11a, which recognizes a surface differentiation antigen associated with the low affinity FcRIII for IgG, expressed on NK-cells, granulocytes and macrophages were found to bind to leukemic cells of four of the 12 Leu-19 positive cases. 50% (6/12) of Leu-19 positive patients were classified as having M4 according to the French-American-British (FAB) morphology criteria. The potential diagnostic and clinical importance of CD 56 and/or CD 16 expression in acute myelogenous leukemia is presently under investigation.

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March 1994
Volume 1 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
ZELLER W, SCHAFER B, BENZ A, GUTENSOHN K, BECKER K, FIEDLER W and HOSSFELD D: EXPRESSION OF NK-ASSOCIATED SURFACE-ANTIGENS CD-56 AND CD-16 ON AML-CELLS. Oncol Rep 1: 411-414, 1994
APA
ZELLER, W., SCHAFER, B., BENZ, A., GUTENSOHN, K., BECKER, K., FIEDLER, W., & HOSSFELD, D. (1994). EXPRESSION OF NK-ASSOCIATED SURFACE-ANTIGENS CD-56 AND CD-16 ON AML-CELLS. Oncology Reports, 1, 411-414. https://doi.org/10.3892/or.1.2.411
MLA
ZELLER, W., SCHAFER, B., BENZ, A., GUTENSOHN, K., BECKER, K., FIEDLER, W., HOSSFELD, D."EXPRESSION OF NK-ASSOCIATED SURFACE-ANTIGENS CD-56 AND CD-16 ON AML-CELLS". Oncology Reports 1.2 (1994): 411-414.
Chicago
ZELLER, W., SCHAFER, B., BENZ, A., GUTENSOHN, K., BECKER, K., FIEDLER, W., HOSSFELD, D."EXPRESSION OF NK-ASSOCIATED SURFACE-ANTIGENS CD-56 AND CD-16 ON AML-CELLS". Oncology Reports 1, no. 2 (1994): 411-414. https://doi.org/10.3892/or.1.2.411