ACCELERATED CHEMOTHERAPY WITH MITOXANTRONE PLUS G-CSF IN HEAVILY PRETREATED PATIENTS WITH METASTATIC BREAST-CANCER

  • Authors:
    • V LORUSSO
    • F BERARDI
    • C TATULLI
    • R SARCINA
    • M DELENA
  • View Affiliations

  • Published online on: May 1, 1994     https://doi.org/10.3892/or.1.3.591
  • Pages: 591-595
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Abstract

Twenty-two women with metastatic breast cancer, previously submitted to one or more lines of chemotherapy, were treated with mitoxantrone as single agent delivered at full dosage (14 mg/m(2)) every other week (accelerated chemotherapy). This dose was possible with concomitant subcutaneous administration of granulocyte colony stimulating factor (G-CSF) on days 5 to 12 of each 14 day cycle. Although grade III-IV leukopenia, anemia and thrombocytopenia were observed in 50%, 13%, and 27% of cases, respectively, a complete recovery of neutrophils, due to G-CSF administration, permitted on time cycle delivery in the majority of cases. Partial response was observed in 6/22 patients (27%). In conclusion, accelerated chemotherapy with mithoxantrone plus G-CSF is both feasible and effective for patients with previously treated breast cancer.

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May 1994
Volume 1 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
LORUSSO V, BERARDI F, TATULLI C, SARCINA R and DELENA M: ACCELERATED CHEMOTHERAPY WITH MITOXANTRONE PLUS G-CSF IN HEAVILY PRETREATED PATIENTS WITH METASTATIC BREAST-CANCER. Oncol Rep 1: 591-595, 1994.
APA
LORUSSO, V., BERARDI, F., TATULLI, C., SARCINA, R., & DELENA, M. (1994). ACCELERATED CHEMOTHERAPY WITH MITOXANTRONE PLUS G-CSF IN HEAVILY PRETREATED PATIENTS WITH METASTATIC BREAST-CANCER. Oncology Reports, 1, 591-595. https://doi.org/10.3892/or.1.3.591
MLA
LORUSSO, V., BERARDI, F., TATULLI, C., SARCINA, R., DELENA, M."ACCELERATED CHEMOTHERAPY WITH MITOXANTRONE PLUS G-CSF IN HEAVILY PRETREATED PATIENTS WITH METASTATIC BREAST-CANCER". Oncology Reports 1.3 (1994): 591-595.
Chicago
LORUSSO, V., BERARDI, F., TATULLI, C., SARCINA, R., DELENA, M."ACCELERATED CHEMOTHERAPY WITH MITOXANTRONE PLUS G-CSF IN HEAVILY PRETREATED PATIENTS WITH METASTATIC BREAST-CANCER". Oncology Reports 1, no. 3 (1994): 591-595. https://doi.org/10.3892/or.1.3.591