NONE OF THE KNOWN DIFFERENT FIBROBLAST GROWTH-FACTOR RECEPTOR-2 CARBOXY-TERMINAL TAILS ARE RESTRICTED TO CANCER-CELLS
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- Published online on: May 1, 1994 https://doi.org/10.3892/or.1.3.639
- Pages: 639-643
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Abstract
Fibroblast growth factor receptor-2 cDNAs derived from healthy tissues code for proteins with a 63 amino acid carboxy-terminal tail. Some cDNAs isolated from human tumour cDNA libraries code for receptors with 11, 15 or 29 amino acid carboxy-terminal tails. However, the important issue as to whether these latter tails are tumour specific markers has remained unresolved. We show that mRNAs coding for FGFR-2 proteins with carboxy-terminal tails of 11, 29 and 63 amino acids are co-expressed not only in many tumour tissues but also in normal human tissues, while the 15 amino acid tail appears to reflect a cloning artefact.