GROWTH-FACTOR REGULATION OF MDM-2 MESSENGER-RNA EXPRESSION
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- Published online on: July 1, 1994 https://doi.org/10.3892/or.1.4.695
- Pages: 695-698
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Abstract
We have investigated the growth factor regulation of mdm-2 mRNA levels in mouse embryo fibroblasts, whose growth is controlled by platelet-derived growth factor (PDGF) and insulin-like growth factor I (IGF-I). We find that both growth factors up-regulate the expression of mdm-2 mRNA, independently of each other.