IN-VIVO STIMULATION OF CELL-PROLIFERATION OF 2 HUMAN TUMOR XENOGRAFT LINES BY GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR (GM-CSF)

  • Authors:
    • G HOFMOCKEL
    • ID BASSUKAS
    • D HEIMBACH
  • View Affiliations

  • Published online on: September 1, 1994     https://doi.org/10.3892/or.1.5.913
  • Pages: 913-916
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Abstract

In the present work the effect of a colony stimulating factor (CSFs), i.e. recombinant human granulocyte-macrophage colony stimulating factor (rhGMCSF), on tumor cell proliferation of a human renal cell carcinoma (RCC) and a squamous cell carcinoma (SCC) xenotransplanted into nude mice was studied. The measurement of the H-3-thymidine labeling index and the mitotic index of the tumor cells of both tumor lines as a function of the GM-CSF dose (0.05-1.00 mu g/g body weight) showed that the cell proliferation in both tumor types increases at low doses (p<0.05). Furthermore, the course of the dose dependent stimulation of cell proliferation is somewhat different for each tumor line. This possible growth stimulating effect of the rhGM-CSF found in the present work for both xenotransplanted tumor types should be considered, when this substance is applied within therapeutic regimens. Intertumoral differences should also be regarded.

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September 1994
Volume 1 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
HOFMOCKEL G, BASSUKAS I and HEIMBACH D: IN-VIVO STIMULATION OF CELL-PROLIFERATION OF 2 HUMAN TUMOR XENOGRAFT LINES BY GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR (GM-CSF). Oncol Rep 1: 913-916, 1994
APA
HOFMOCKEL, G., BASSUKAS, I., & HEIMBACH, D. (1994). IN-VIVO STIMULATION OF CELL-PROLIFERATION OF 2 HUMAN TUMOR XENOGRAFT LINES BY GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR (GM-CSF). Oncology Reports, 1, 913-916. https://doi.org/10.3892/or.1.5.913
MLA
HOFMOCKEL, G., BASSUKAS, I., HEIMBACH, D."IN-VIVO STIMULATION OF CELL-PROLIFERATION OF 2 HUMAN TUMOR XENOGRAFT LINES BY GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR (GM-CSF)". Oncology Reports 1.5 (1994): 913-916.
Chicago
HOFMOCKEL, G., BASSUKAS, I., HEIMBACH, D."IN-VIVO STIMULATION OF CELL-PROLIFERATION OF 2 HUMAN TUMOR XENOGRAFT LINES BY GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR (GM-CSF)". Oncology Reports 1, no. 5 (1994): 913-916. https://doi.org/10.3892/or.1.5.913